HOME >> BIOLOGY >> NEWS
Protein mimetics could lead to more successful coronary bypasses

TEMPE, ARIZONA, May 12, 2003 -- Severe spasm of blood vessels contributes to the failure of coronary bypass surgeries and to strokes following the rupture of an aneurysm in the brain. A complex signaling pathway controls relaxation in smooth muscle cells, but researchers at Arizona State University have discovered how to bypass it.

The research team has created a mimetic of the last protein in the pathway, HSP20, which causes relaxation in the same way as the natural protein. This research, published May 8 in the online version of The FASEB Journal, is a major step in the development of a drug that promotes blood vessel relaxation.

The signaling pathway that causes relaxation in smooth muscle cells involves many different proteins, but the last step is the addition of a phosphate group, or phosphorylation, of the protein HSP20, which actually effects relaxation.

Other groups have developed molecules, such as the active ingredient in Viagra, that affect earlier steps in this pathway. But if a problem occurs in later steps, these compounds are ineffective.

"You've got all those signaling pathways, but, boom, you can bypass them by putting in a mimetic of the protein that's the effector molecule," said primary investigator Colleen Brophy, research professor of bioengineering at ASU, director of the Center for Protein and Peptide Pharmaceuticals in the Arizona Biodesign Institute, and chief of vascular surgery at the Carl T. Hayden Veterans Affairs Medical Center.

The HSP20 mimetic developed at ASU consists of a 13 amino acid stretch of the protein attached to a protein transduction domain, a peptide that allows the mimetic to enter cells. The HSP20 portion of the mimetic includes a phosphate group attached to the same amino acid as in the active version of natural HSP20.

Brophy and colleagues measured the contraction of thin rings of smooth muscle from the coronary arteries of pigs with a force transducer. They pre-contract
'"/>

Contact: Linley Hall
linley.hall@asu.edu
480-965-5854
Arizona State University
12-May-2003


Page: 1 2

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein controls acid in cells by direct detection of volume changes, study finds
9. Protein believed to control formation of memory identified by Scripps & UCSD scientists
10. Protein stops blood-vessel growth, holds promise as cancer therapy
11. Proteins transform DNA into molecular velcro

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein mimetics could lead more successful coronary bypasses

(Date:10/29/2014)... Online registration is open for the ... Scientific Meeting. SIR 2015 is the one ... trainees and related health care professionals can ... image-guided science and technologies being presented, discussed ... community in minimally invasive, image-guided medicine, SIR ...
(Date:10/29/2014)... sunlight to make their food, but they also need protection ... discovered a group of molecules in plants that shields them ... Journal of the American Chemical Society , one team reports ... , Timothy Zwier and colleagues at Purdue University note that ... cause serious damage to plant DNA and, as a result, ...
(Date:10/29/2014)... the rage. Thousands of scientists worldwide are conducting research ... dioxide nanoparticles from sun creams can get through the ... electronic products are as hazardous for the lungs as ... can get into the blood via the intestinal flora, ... flowing – and the number of scientific projects is ...
Breaking Biology News(10 mins):SIR 2015: Interventional radiology shapes tomorrow's medicine 2Nanosafety research: The quest for the gold standard 2Nanosafety research: The quest for the gold standard 3
(Date:10/31/2014)... The report "Offshore Support Vessel Market ... Supply Vessels, Multi-Purpose Service Vessel, Crew Boats, Standby & ... Trends & Forecast to 2018", defines and segments the ... the global revenue. , Offshore support vessel market is ... to $ 91,228.8 Million by 2018, with a CAGR ...
(Date:10/31/2014)... IL (PRWEB) October 30, 2014 ... Insight Product Developmentā€™s decades-long heritage in successful medical ... world context for what it takes to successfully ... space. As part of a two-hour on-site class, ... Kellogg school of business, McCormick School of Engineering, ...
(Date:10/31/2014)... 31, 2014 This is a ... China Biocides industry. The report provides basic biocides ... chain structure as well as industry overview. This ... domestic market as well as Global industry analysis ... report on the Chinese biocides industry ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 Stronger ... healthcare, construction, finance and consumer electronics will help ... reason, industry research firm IBISWorld has added a ... its growing industry report collection. , The Biometrics ... for biometric technologies such as fingerprint, iris, retina ...
Breaking Biology Technology:Offshore Support Vessel Market Projected to Reach $91,228.8 Million by 2018 - Report by MarketsandMarkets 2Offshore Support Vessel Market Projected to Reach $91,228.8 Million by 2018 - Report by MarketsandMarkets 3Offshore Support Vessel Market Projected to Reach $91,228.8 Million by 2018 - Report by MarketsandMarkets 4Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 2Insight Product Development Gives Northwestern University Students Foundation for Innovation Success 3Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 2Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 3Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 3
Cached News: