HOME >> BIOLOGY >> NEWS
Protein mimetics could lead to more successful coronary bypasses

TEMPE, ARIZONA, May 12, 2003 -- Severe spasm of blood vessels contributes to the failure of coronary bypass surgeries and to strokes following the rupture of an aneurysm in the brain. A complex signaling pathway controls relaxation in smooth muscle cells, but researchers at Arizona State University have discovered how to bypass it.

The research team has created a mimetic of the last protein in the pathway, HSP20, which causes relaxation in the same way as the natural protein. This research, published May 8 in the online version of The FASEB Journal, is a major step in the development of a drug that promotes blood vessel relaxation.

The signaling pathway that causes relaxation in smooth muscle cells involves many different proteins, but the last step is the addition of a phosphate group, or phosphorylation, of the protein HSP20, which actually effects relaxation.

Other groups have developed molecules, such as the active ingredient in Viagra, that affect earlier steps in this pathway. But if a problem occurs in later steps, these compounds are ineffective.

"You've got all those signaling pathways, but, boom, you can bypass them by putting in a mimetic of the protein that's the effector molecule," said primary investigator Colleen Brophy, research professor of bioengineering at ASU, director of the Center for Protein and Peptide Pharmaceuticals in the Arizona Biodesign Institute, and chief of vascular surgery at the Carl T. Hayden Veterans Affairs Medical Center.

The HSP20 mimetic developed at ASU consists of a 13 amino acid stretch of the protein attached to a protein transduction domain, a peptide that allows the mimetic to enter cells. The HSP20 portion of the mimetic includes a phosphate group attached to the same amino acid as in the active version of natural HSP20.

Brophy and colleagues measured the contraction of thin rings of smooth muscle from the coronary arteries of pigs with a force transducer. They pre-contract
'"/>

Contact: Linley Hall
linley.hall@asu.edu
480-965-5854
Arizona State University
12-May-2003


Page: 1 2

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein controls acid in cells by direct detection of volume changes, study finds
9. Protein believed to control formation of memory identified by Scripps & UCSD scientists
10. Protein stops blood-vessel growth, holds promise as cancer therapy
11. Proteins transform DNA into molecular velcro

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... 2017  Hunova, the first robotic gym for the rehabilitation and functional ... in Genoa, Italy . The first 30 robots will ... USA . The technology was developed and patented at ... IIT spin-off Movendo Technology thanks to a 10 million euro investment from ... click: ...
(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
(Date:4/13/2017)... 13, 2017 UBM,s Advanced Design and Manufacturing ... feature emerging and evolving technology through its 3D Printing ... run alongside the expo portion of the event and ... demonstrations focused on trending topics within 3D printing and ... manufacturing event will take place June 13-15, 2017 at the ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... , ... October 12, 2017 ... ... announces publication of a United States multicenter, prospective clinical study that demonstrates ... point-of-care diagnostic test capable of identifying clinically significant acute bacterial and viral ...
(Date:10/12/2017)... ... October 12, 2017 , ... AMRI, a global contract ... to improve patient outcomes and quality of life, will now be offering its ... attributed to new regulatory requirements for all new drug products, including the finalization ...
(Date:10/11/2017)... ... October 11, 2017 , ... At its ... announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief research scientist of ... been selected for membership in ARCS Alumni Hall of Fame . ASTER ...
(Date:10/11/2017)... ... 11, 2017 , ... Personal eye wash is a basic first aid supply for any work ... which eye do you rinse first if a dangerous substance enters both eyes? It’s one ... with its unique dual eye piece. , “Whether its dirt and debris, or an ...
Breaking Biology Technology:
Cached News: