HOME >> BIOLOGY >> NEWS
Protein mimetics could lead to more successful coronary bypasses

TEMPE, ARIZONA, May 12, 2003 -- Severe spasm of blood vessels contributes to the failure of coronary bypass surgeries and to strokes following the rupture of an aneurysm in the brain. A complex signaling pathway controls relaxation in smooth muscle cells, but researchers at Arizona State University have discovered how to bypass it.

The research team has created a mimetic of the last protein in the pathway, HSP20, which causes relaxation in the same way as the natural protein. This research, published May 8 in the online version of The FASEB Journal, is a major step in the development of a drug that promotes blood vessel relaxation.

The signaling pathway that causes relaxation in smooth muscle cells involves many different proteins, but the last step is the addition of a phosphate group, or phosphorylation, of the protein HSP20, which actually effects relaxation.

Other groups have developed molecules, such as the active ingredient in Viagra, that affect earlier steps in this pathway. But if a problem occurs in later steps, these compounds are ineffective.

"You've got all those signaling pathways, but, boom, you can bypass them by putting in a mimetic of the protein that's the effector molecule," said primary investigator Colleen Brophy, research professor of bioengineering at ASU, director of the Center for Protein and Peptide Pharmaceuticals in the Arizona Biodesign Institute, and chief of vascular surgery at the Carl T. Hayden Veterans Affairs Medical Center.

The HSP20 mimetic developed at ASU consists of a 13 amino acid stretch of the protein attached to a protein transduction domain, a peptide that allows the mimetic to enter cells. The HSP20 portion of the mimetic includes a phosphate group attached to the same amino acid as in the active version of natural HSP20.

Brophy and colleagues measured the contraction of thin rings of smooth muscle from the coronary arteries of pigs with a force transducer. They pre-contract
'"/>

Contact: Linley Hall
linley.hall@asu.edu
480-965-5854
Arizona State University
12-May-2003


Page: 1 2

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein controls acid in cells by direct detection of volume changes, study finds
9. Protein believed to control formation of memory identified by Scripps & UCSD scientists
10. Protein stops blood-vessel growth, holds promise as cancer therapy
11. Proteins transform DNA into molecular velcro

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/27/2017)... CENTRE, N.Y. , March 27, 2017 /PRNewswire-USNewswire/ ... Healthcare Information and Management Systems Society (HIMSS) Analytics ... Outpatient EMR Adoption Model sm . In addition, ... 12% of U.S. hospitals using an electronic medical ... CHS for its high level of EMR usage ...
(Date:3/24/2017)... DUBLIN , Mar 24, 2017 Research ... Vehicle Access System Market Analysis & Trends - Industry Forecast to ... ... poised to grow at a CAGR of around 15.1% over the ... This industry report analyzes the market estimates and forecasts for ...
Breaking Biology News(10 mins):
(Date:10/7/2017)... WA (PRWEB) , ... October ... ... industry leader in Hi-C-based genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution ... ProxiMeta Hi-C kit and accompanying cloud-based bioinformatics software to perform Hi-C metagenome ...
(Date:10/6/2017)... ... October 06, 2017 , ... The HealthTech Venture ... sector at their fourth annual Conference where founders, investors, innovative practitioners and collaborators ... ELEVATE pitch competition showcasing early stage digital health and med tech companies. , ...
(Date:10/5/2017)... ... October 05, 2017 , ... LabRoots , the leading provider of ... world, is giving back to cancer research with a month-long promotion supporting the advancement ... October 31, shoppers can use promo code PinkRibbon to get 10 percent off their ...
(Date:10/5/2017)... ... October 05, 2017 , ... NIH has awarded Circulomics ... Nanobind DNA/RNA extraction technology . Nanobind is a novel magnetic disk that contains ... can be used for a wide variety of sample preparation applications. The nanostructured ...
Breaking Biology Technology:
Cached News: