HOME >> BIOLOGY >> NEWS
'Protein-only' prions confirmed in FSU yeast study

TALLAHASSEE, Fla.--A key discovery about how prions -- mysterious bits of protein thought to be the cause of mad cow disease and similar brain disorders -- infect healthy cells is being hailed by scientists as a breakthrough in the quest to understand the role of these proteins in neurological diseases.

The findings by two Florida State University scientists are described in the March 18 issue of the journal Nature.

What they found, according to co-discoverer Chih-Yen King, is the "first definitive proof" that prions can transfer heritable traits from one living system to another without the help of gene-carrying DNA or its cousin RNA, compounds called nucleic acids. The finding means that what school kids have been taught for decades -- that DNA is the basis of all heredity, including the transmission of deadly diseases -- now must be revisited, says Donald Caspar, a structural biologist based in FSU's Institute of Molecular Biophysics. King and his co-discoverer, Ruben Diaz-Avalos, are post-doctoral scientists in Caspar's lab.

King and Diaz-Avalos, working with yeast cultures, isolated and identified three different strains of yeast prions, each of which were found to originate from the same protein molecule that, for reasons yet unknown, turned into infectious prions. The team found that these all-protein particles act like genes in transferring life-changing information in yeast cells without relying on DNA or RNA as the information carriers.

Work by Jonathan Weissman at the University of California, San Francisco, whose research also appears in Nature, reached the same conclusions as the FSU scientists, albeit from a different angle. Also using yeast cultures as a model, Weissman's group isolated and identified two distinct yeast prion strains caused by "protein-only" prions.

Collectively, the research helps resolve the most puzzling question in prion research, King said. Since prions were first hypothesized in 1982 by Stanl
'"/>

Contact: Ross Ellington
elling@sb.fsu.edu
850-644-0451
Florida State University
17-Mar-2004


Page: 1 2 3

Related biology news :

1. Researchers make major gain in understanding how prions jump species
2. Artificial prions created
3. Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
4. Study shows prions stick around in certain soils
5. UCSF-led team reports new test improves detection of prions in animals
6. Scientists at the Scripps Research Institute find a way to block prions that cause mad cow disease
7. A dose of prions might slow the progress of prion diseases.
8. Deadly to cattle and humans, prions may help other organisms survive, researchers find
9. Early treatment confirmed as key to stroke recovery
10. Fears of second-hand smoke confirmed
11. New target for skin cancer confirmed

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... ... gene-to-protein and monoclonal antibody development services, today announced that the company has ... services to the pharmaceutical, diagnostics, and research industries. The decision to pursue ...
(Date:6/23/2020)... ... June 23, 2020 , ... Rigaku ... the next event in a series of TOPIQ webinars, which will cover the ... webinars was developed in response to social distancing measures that resulted in postponements ...
(Date:6/19/2020)... ... June 18, 2020 , ... ... “Automate Your Lab with Software for Data Decisions,” for pharmaceutical and biotech ... to integrate and automate cutting-edge scientific instruments and laboratory equipment from dozens ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... PathSensors Inc., ... has expanded the company’s exclusive license to include clinical applications for CANARY™ ... market, focusing initially on the SARS-CoV-2 biosensor. CANARY’s™ fast and highly ...
(Date:7/7/2020)... ... July 06, 2020 , ... R3 International is now offering stem cell therapy ... stem cells. Depending on the patient's condition, treatment may be offered IV, intrathecal or ... some form of Alzheimers dementia, and the incidence continues to increase as individuals live ...
(Date:7/1/2020)... ... June 29, 2020 , ... The Interlocal Purchasing System (TIPS), ... membership, recently named BioFit Engineered Products an Awarded Vendor. Awarded Vendor ... seating, cafeteria tables, book trucks and carts at discounted pricing without the delay ...
(Date:6/28/2020)... JOSE, Calif. (PRWEB) , ... June 25, 2020 ... ... globe, researchers are racing to develop a vaccine or drug treatment. In an ... Recursion has publicly released the world’s largest imaging dataset portraying therapeutic ...
Breaking Biology Technology:
Cached News: