HOME >> BIOLOGY >> NEWS
Protein research illustrates how drugs fight malaria, other diseases

s for selective drug action are incomplete," he said.

In the current research, Zhang and Rathod found that parasites are sensitive to drugs that target their DHFR in part because of their inability to rapidly replenish the dead enzyme. Host cells, on the other hand, can rapidly generate excess amounts of the DHFR protein if the drug accidentally enters the host cell. Previously, it was believed the different effects between parasite and host were entirely related to how tightly the drug used against the parasite was bound to the DHFR protein in the parasite.

The latest research offers a new standard for selective targeting, Rathod said. He likens it to the military establishing a battle plan based on good intelligence.

"You can have all the maps, you can have all the guns, you can have all the firepower, but if you don't know where the important targets are, it's a waste. You can do as much harm as good," he said.

The Science paper focuses on malaria, a disease that each year strikes one-seventh of the world's population 900 million people, mostly in southern Asia, sub-Saharan Africa and central and South America and kills 2.7 million people.

However, the same concepts could apply to research into, for example, HIV, cancer, heart disease or Alzheimer's disease, Rathod said. The goal is finding the means to attack certain kinds of cells in ways that aren't toxic to other cells, even cells similar to the ones being attacked.

Malaria is the focus of research in Rathod's lab because it is so widespread and often affects some of the world's poorest populations. In some parts of Africa, for example, many people infected with malaria would be hard pressed to pay even $10 a year for medication, Rathod said. Solving a problem of that magnitude will require scientists, drug manufacturers and social agencies to work together, he said.

"Malaria is a big issue because no vaccines have worked," he said. "Medications have w
'"/>

Contact: Vince Stricherz
vinces@u.washington.edu
206-543-2580
University of Washington
18-Apr-2002


Page: 1 2 3

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein controls acid in cells by direct detection of volume changes, study finds
9. Protein believed to control formation of memory identified by Scripps & UCSD scientists
10. Protein stops blood-vessel growth, holds promise as cancer therapy
11. Proteins transform DNA into molecular velcro

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/30/2019)... ... September 30, 2019 , ... ... molecular manufacturing and other transformative technologies, announced the winners for the 2019 Foresight ... the other for Theory in nanotechnology/molecular manufacturing. , Established in 1993 and named ...
(Date:9/30/2019)... ... ... As human induced pluripotent stem cells (hiPSCs) move closer to becoming a ... the human heart, there is an increasing need for stable stem cell lines that ... and easily recorded. A study released today in STEM CELLS details the development of ...
(Date:9/30/2019)... Calif. (PRWEB) , ... September ... ... a leading think tank, research, and public interest organization focused on molecular ... Distinguished Student Prize. , The Award recognizes the College graduate or undergraduate ...
Breaking Biology News(10 mins):
(Date:10/3/2019)... , ... October 02, 2019 , ... ... life sciences leadership firm that is enabling clinical program outsourcing success by cultivating ... by award-winning pharma and biotech veteran executive Brenda Reese, phaseUP™ brings clients deep, ...
(Date:10/3/2019)... BOSTON (PRWEB) , ... October 03, 2019 , ... Yesterday, ... 2-3, Asymmetrex founder and director, James L. Sherley, M.D., Ph.D., discussed important ... To an attendee audience including both developers and suppliers of clinical trials, in ...
(Date:9/24/2019)... ... September 24, 2019 , ... ... delivery technologies, development, and manufacturing solutions for drugs, biologics, gene therapies, and ... company focused on the development of therapies to treat central nervous system ...
(Date:9/22/2019)... ... 20, 2019 , ... ZRT Laboratory is pleased ... serum . BDNF plays a vital role in protecting existing neurons in the ... neurons in the brain involved in learning, memory, and higher thinking. Low serum ...
Breaking Biology Technology:
Cached News: