HOME >> BIOLOGY >> NEWS
Protein study suggests ways to help humans thwart viruses

WEST LAFAYETTE, Ind. Scientists have unraveled a genetic anomaly that protects some mice from a common cancer-causing virus.

The findings may help develop gene therapies that can be used to help humans defeat similar viruses, such as the human T-cell leukemia virus and the AIDS virus, says David A. Sanders, associate professor of biological sciences at Purdue University and lead author of the study.

Sanders and his research group at Purdue analyzed proteins in mice that are resistant to the ecotropic murine leukemia virus, a major cancer-causing virus that occurs only in mice. A very similar virus is the agent of feline leukemia, the major cause of serious illness and death in cats.

Scientists have known for years that mice that have an active Fv-4 gene are resistant to the virus, though it wasn't clear how this resistance occurred.

Their findings show how a defective protein found in mice with the Fv-4 gene works by binding with the receptor that normally serves as a doorway for viral entry, and thereby blocking the door.

"The protein looks normal, and is processed normally and incorporated into virus particles, but it is unable to promote viral entry," Sanders says. "By identifying the defect in this mouse protein and introducing it into another virus, we have found a potential new avenue for preventing viruses from entering cells."

Sanders says the method may someday be applied to block similar viruses, which belong in a class known as retroviruses. Retroviruses are a major group of cancer-causing viruses that use a unique production method to copy and insert their genetic material into a host cell.

Human cells also contain specialized receptors for retrovirus entry, Sanders says.

"Such receptors are often very specific," he says. "We know, for example, that people who don't have the receptor for HIV are resistant to HIV."

His research group is now working to apply knowledge of how this g
'"/>

Contact: Susan Gaidos
sgaidos@purdue.edu
765-494-2081
Purdue University
18-Dec-2001


Page: 1 2 3

Related biology news :

1. Protein is key to fatal disorder and normal cell function
2. Protein is key for digestive function of the pancreas
3. Proteins show promise for mosquito control
4. Protein involved in childhood disorder linked to cancer
5. Protein fishing in America: The movie
6. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
7. Protein key to trafficking in nerve terminals
8. Protein controls acid in cells by direct detection of volume changes, study finds
9. Protein believed to control formation of memory identified by Scripps & UCSD scientists
10. Protein stops blood-vessel growth, holds promise as cancer therapy
11. Proteins transform DNA into molecular velcro

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... Delta (NYSE: DAL ) customers now can use fingerprints instead ... National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in ... the boarding process to allow eligible Delta SkyMiles Members who are enrolled ...
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at ... between startups and global businesses, taking place in ... startups will showcase the solutions they have built with IBM ... France is one of the most ... increase in the number of startups created between 2012 and ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights ... (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital ...
(Date:10/10/2017)... International research firm Parks Associates announced today that ... TMA 2017 Annual Meeting , October 11 in Scottsdale, ... security market and how smart safety and security products impact the competitive ... Parks Associates: Smart Home Devices: Main ... "The residential security market has experienced continued ...
(Date:10/10/2017)... ... October 10, 2017 , ... The ... prestigious awards honoring scientists who have made outstanding contributions to analytical ... during Pittcon 2018, the world’s leading conference and exposition for laboratory science, which ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in North ... in Harvard University’s Departments of Physics and Astronomy, has been selected for membership in ... winning team for the 2015 Breakthrough Prize in Fundamental physics for the discovery of ...
Breaking Biology Technology:
Cached News: