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Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin

nificant step forward in vaccine development," said George V. Ludwig, Ph.D., acting science director for USAMRIID. "In the past, our reliance on using natural proteins and other immunogens limited our ability to make useable and producible vaccines. New techniques such as those described offer nearly unlimited possibilities."

According to Smith, the next step will be to test the new ricin vaccine in nonhuman primates. He said the team also is working to refine a scaled-up production method that is robust and reproducible. This involves optimizing the fermentation process, developing a process for purification, and refining the analytical methods for characterizing both the manufacturing process and the final product. In addition, USAMRIID is conducting pre-formulation studies to produce a formulated vaccine that will induce the optimum immune response possible in animal models.


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Contact: Caree Vander Linden
Caree.Vander-Linden@amedd.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
4-Aug-2004


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