HOME >> BIOLOGY >> NEWS
Proteins Interacting With RNA And DNA Are Surprisingly Similar

Chemists trying to produce new and more effective antibiotics have made a surprising discovery; a protein that attaches itself to RNA, making it possible for a certain antibiotic to fight bacterial infection, is remarkably similar to a class of proteins that bind to DNA.

The proteins have the same general shape, and they use a similar method to bind to RNA and DNA. Those similarities came as a surprise because the proteins have completely different functions, and they attach to different structures -- the double-stranded, ladder-like DNA, and the single-stranded RNA.

"You don't expect RNA-binding proteins to look like DNA-binding proteins because the structures in DNA and RNA are quite different," said David Draper, a Johns Hopkins University chemist who is heading the research team that made the discovery.

Draper's team discovered that the RNA- and DNA-binding proteins have the same shape, a configuration of three coils called alpha helices. Not only do they have the same shape, the proteins attach to RNA and DNA at precisely the same points along one of their coils.

A scientific paper detailing the findings was published in the January issue of a British science journal, Nature Structural Biology.

The discovery suggests that the RNA-binding protein, called L11, could be an ancient, ancestral form of other proteins that bind to DNA and are crucial to an embryo's development, turning on and off various genes needed to form specific anatomical features.

L11 has existed for at least 2 billion years, since the time when higher organisms began to diverge from bacteria. By comparison, the similar DNA- binding proteins, called homeodomain proteins, first emerged only about 400 million years ago, Draper said.

In the cells of living organisms, L11 attaches to ribosomes, particles that produce proteins. The L11 enables the ribosomes to make proteins twice as fast. When it attaches to the ribosomes in bacteria, the bacteria are able to multiply much
'"/>

Contact: Emil Venere
Emil@jhu.edu
410-516-7160
Johns Hopkins University
3-Jan-1997


Page: 1 2 3

Related biology news :

1. Proteins show promise for mosquito control
2. Proteins transform DNA into molecular velcro
3. Proteins may help identify patients who will respond better to treatments in certain cancers
4. Proteins enable HIV to override cells defenses
5. New Science Press launches Proteins: From Sequence to Structure
6. Report: Proteins can be engineered as widely adaptable bioelectronic sensors
7. Proteins in African HIV strains interact differently with drugs
8. Proteins are vastly more complicated than previously realized
9. Life and death struggle: Proteins play against each other, bringing balance to immune system
10. Proteins that bind to sperm offer clues to male fertility and possible male contraception
11. Scientists Show Proteins Function Individually As Part Of DNA Repair

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... 2017 Today HYPR Corp. , leading ... component of the HYPR platform is officially FIDO® ... security architecture that empowers biometric authentication across Fortune 500 ... secured over 15 million users across the financial services ... home product suites and physical access represent a growing ...
(Date:3/30/2017)... , March 30, 2017 The research team ... for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint ... new realm of speed and accuracy for use in identification, crime ... affordable cost. ... A ...
(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... ... 2017 , ... Today, 3Bar Biologics Inc ., the ... funding from an impressive group of investors, including Rev1 Ventures, Maumee Ventures, Ohio ... investment, 3Bar is broadening availability of its groundbreaking offering that uses naturally occurring ...
(Date:8/15/2017)... After spending the past two years building a state-of-the-art ... GeneFo now offers this platform to healthcare stakeholders (hospitals, foundations, biopharma ... and data collection vis a vis their members, under their own ... of this offer. ... ...
(Date:8/15/2017)... ... 2017 , ... Any expert in stem cell research or stem cell medicine ... half a century. Despite their essential roles in human health and regenerative medicine, ... tags developed for this purpose also tag other, more abundant, non-stem tissue cells ( ...
(Date:8/15/2017)... ... August 15, 2017 , ... JULABO USA introduces ... the new website makes it easy to navigate through the site whether you’re ... find detailed product information, educational industry content and visit the company’s social media ...
Breaking Biology Technology:
Cached News: