HOME >> BIOLOGY >> NEWS
Proteins Interacting With RNA And DNA Are Surprisingly Similar

faster than they ordinarily would because the rate of protein production is doubled.

An antibiotic called thiostrepton works by attaching to both the L11 protein and the ribosomal RNA of infection-causing bacteria, preventing the production of protein and controlling the bacterial infection.

But, although a nearly identical protein also is attached to the ribosomes of higher forms of life, the antibiotic will only bind to the bacterial RNA.

How the antibiotic distinguishes between the two types of RNA is a mystery, since the segment of RNA that the protein binds to is very similar in bacteria and higher organisms. There must be specific features that are only present in the bacterial RNA, Draper said.

"Those are very handy features because that means you can design drugs to target just bacteria and not kill the host," he said.

RNA, or ribonucleic acid, is essential in the manufacture of proteins ranging from vital enzymes and hormones to hemoglobin and structural components. DNA, or deoxyribonucleic acid, contains the huge library of genetic information organisms need to reproduce and to make RNA. Both RNA and DNA are made of molecules called nucleotides. But RNA is a single-stranded compound of the molecules and DNA has two strands, which are connected in a twisting structure called a double helix.

Learning why the RNA- and DNA-binding proteins are so similar could lead to insights specifically about the protein's interaction with RNA, which could shed light on how the antibiotic distinguishes between the two forms of RNA. Such insights could one day enable scientists to make better antibiotics.

In the search for more effective antibiotics, Draper is working with a biotechnology company to investigate compounds that bind to the same segment of RNA as thiostrepton. Thiostrepton is not water-soluble enough to be taken orally. Consequently, the antibiotic, which is used to treat ear infections in animals, can be administered only externally, as a
'"/>

Contact: Emil Venere
Emil@jhu.edu
410-516-7160
Johns Hopkins University
3-Jan-1997


Page: 1 2 3

Related biology news :

1. Proteins show promise for mosquito control
2. Proteins transform DNA into molecular velcro
3. Proteins may help identify patients who will respond better to treatments in certain cancers
4. Proteins enable HIV to override cells defenses
5. New Science Press launches Proteins: From Sequence to Structure
6. Report: Proteins can be engineered as widely adaptable bioelectronic sensors
7. Proteins in African HIV strains interact differently with drugs
8. Proteins are vastly more complicated than previously realized
9. Life and death struggle: Proteins play against each other, bringing balance to immune system
10. Proteins that bind to sperm offer clues to male fertility and possible male contraception
11. Scientists Show Proteins Function Individually As Part Of DNA Repair

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/4/2020)... , ... July 03, 2020 , ... ... to earn outstanding recognition and multiple awards for not only the products and ... portfolio, SoME® Skincare and Vivace® Microneedle RF. All the brands built by ABM ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... (MBS) has announced a publication detailing the use of its revolutionary NEXTGENPCR ... chain reaction (RT-PCR) in 16 minutes. The article, titled "Ultra-fast one-step RT-PCR ...
(Date:7/1/2020)... , ... July 01, 2020 , ... ... awareness and solutions for glioblastoma—the most common and aggressive adult brain cancer—announced today ... JD, PhD. Senior Fellows are charged with supporting the organization’s initiatives and overall ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... software for the life sciences industry, today announced the release of its ... specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
(Date:7/18/2020)... ... July 17, 2020 , ... ... firm for the life sciences and food industries, is pleased to announce that ... Clinical Research – Business Development. , Charles is an accomplished and results-driven sales ...
(Date:7/7/2020)... DIEGO (PRWEB) , ... July 06, 2020 , ... R3 ... new program featuring up to 200 million stem cells. Depending on the patient's condition, ... seniors in the US will die having some form of Alzheimers dementia, and the ...
(Date:6/28/2020)... NIGUEL, Calif. (PRWEB) , ... June 25, 2020 , ... ... announced the launch of Safe Space™ for businesses of all types to ensure cleanliness, ... 3D LiDAR. , A Safe Space™ enabled business will provide a health ...
Breaking Biology Technology:
Cached News: