Proteins are vastly more complicated than previously realized

ison of the early stages of forced unfolding for fibronectin type III modules" appears in the May 1 Proceedings of the National Academy of Science, a journal of the National Academy of Sciences.

Fibronectin is a useful protein for studying the effects of mechanical force. Fibronectin is found in connective tissue, such as the skin. In the skin, cells are suspended in the extracellular matrix consisting of thousands of protein fibers that attach to cells at numerous points. These proteins connect with other proteins and hold the mass together a sort of super glue for cells. It is the movement of these fibers and the resulting pull and push on the cells attached to them, that transmits force to the cells.

Vogel and colleagues ask these questions: What does force do to the fiber? How is force transmitted from the fiber to the cell? And how is force used to determine how the cell regulates the expression of certain proteins? "We are very excited about this because we believe a new field is being born: non-equilibrium protein structure-function analysis. Its very exciting to think about how nature regulates and controls function. We went from viewing the cell as a bag full of proteins a decade ago to a view of the cell as a dynamic place where proteins assemble and change under mechanical forces," Vogel says.

This new field became possible only in 1997, with the technology that allowed researchers to see what happens when you grab either end of a protein and stretch, using tools such as atomic-force microscopy. They found that proteins rupture as stretching forces overcome energy barriers that stabilize the protein structure.

"Computer simulations allow us to see what happens to the structure if the protein ruptures," Vogel says. The computer simulations were done in collaboration with Dr. Klaus Schulten at the Beckman Institute in Illinois and former UW graduate student Andre Krammer. "People tend to think of protein function as biochemical che

Contact: Walter Neary
University of Washington

Page: 1 2 3

Related biology news :

1. Proteins show promise for mosquito control
2. Proteins transform DNA into molecular velcro
3. Proteins may help identify patients who will respond better to treatments in certain cancers
4. Proteins enable HIV to override cells defenses
5. New Science Press launches Proteins: From Sequence to Structure
6. Report: Proteins can be engineered as widely adaptable bioelectronic sensors
7. Proteins in African HIV strains interact differently with drugs
8. Life and death struggle: Proteins play against each other, bringing balance to immune system
9. Proteins that bind to sperm offer clues to male fertility and possible male contraception
10. Scientists Show Proteins Function Individually As Part Of DNA Repair
11. Genes Found That Label Cell Proteins For Disposal

Post Your Comments:

(Date:2/11/2020)... ... February 11, 2020 , ... Modality Solutions, ... achieved its ISO 9001:2015 registration by certification body Intertek. Modality Solutions’ Quality Manager, ... and revised all existing Standard Operating Procedures (SOPs) and created ten new SOPs. ...
(Date:2/11/2020)... , ... February 11, 2020 , ... ... into The LaunchPort™ medical device accelerator in Port Covington, Baltimore. The newly formed ... that must be addressed to manage increased demand for home dialysis treatments. The ...
(Date:2/7/2020)... ... February 07, 2020 , ... dicentra , a leading ... nutraceutical and dietary supplement industries, announces 2020 membership with the International Probiotics Association ... research pertaining to probiotics. We are thrilled to join our IPA member colleagues ...
Breaking Biology News(10 mins):
(Date:2/10/2020)... ... , ... R3 Medical Training announced it is now registering for its next ... course is hands on involving real patients and stem cell biologics, with every attendee ... Cell Training Course has received rave reviews from attendees, who love the hands on ...
(Date:2/5/2020)... Fla. (PRWEB) , ... February 05, 2020 , ... ... annual observance, sponsored by The National Organization for Rare Disorders (NORD), to raise awareness ... lives ( rarediseaseday.org ). The Balancing Act’s “Behind The Mystery” rare disease ...
(Date:2/3/2020)... ... February 03, 2020 , ... Global molecular ... that OmniType, the 11-locus, single tube multiplex successor to Holotype HLA is available ... featuring locus-multiplexing and short library preparation, for HLA genotyping from sample to answer ...
(Date:1/28/2020)... ... January 28, 2020 , ... ... solutions for biopharmaceutical R&D, today announced the release of Genedata Expressionist ... on supporting the implementation of Multi-Attribute Methods (MAM) for characterizing and monitoring ...
Breaking Biology Technology:
Cached News: