HOME >> BIOLOGY >> NEWS
Proteins show promise for mosquito control

MADISON-Mosquito abatement usually means one thing: blasting the pesky critters with pesticides. Those pesticides, although highly effective, can impair other organisms in the environment.

Que Lan, insect physiologist at the University of Wisconsin-Madison, and her colleagues in the entomology department are working on a new, more targeted approach to mosquito control: inhibiting their ability to metabolize cholesterol.

Cholesterol, the sticky substance that accumulates on the lining of human arteries, is an important component of cell membranes in vertebrates and invertebrates. In mosquitoes, it is vital for growth, development and egg production.

Unlike humans, mosquitoes cannot synthesize cholesterol. They must obtain it from decomposed plants they eat while in their larval stage, living in shallow waters. Plants make phytosterol, which is converted to cholesterol in the mosquito's gut.

Using the yellow fever mosquito, Aedes aegypti, Lan and her research colleagues discovered that a sterol-carrying protein, AeSCP-2, is the vehicle that transports cholesterol in mosquito cells. Cholesterol is hydrophobic. In order to transport it in a liquid medium, such as blood or cell fluids, organisms must have a way to shield it from the watery environment through which it moves. That shield is typically a carrier protein, such as SCP-2.

Lan and her colleagues reasoned that if they could block the carrier protein, it would disrupt the uptake of cholesterol by the mosquito. Screening what she calls "a small chemical library of 16,000 compounds," Lan and her team found 57 compounds that inhibited the cholesterol-binding capacity of SCP-2.

The top five most viable inhibitor compounds were then tested on mosquito larvae, producing promising results--the larvae died. The results were dose-dependent; that is, at higher concentrations, larger numbers of larvae died. Still, the concentrations were very small, Lan says, in the range of 10 part
'"/>

Contact: Que Lan
qlan@entomology.wisc.edu
608-263-7924
University of Wisconsin-Madison
10-Sep-2004


Page: 1 2 3

Related biology news :

1. Proteins transform DNA into molecular velcro
2. Proteins may help identify patients who will respond better to treatments in certain cancers
3. Proteins enable HIV to override cells defenses
4. New Science Press launches Proteins: From Sequence to Structure
5. Report: Proteins can be engineered as widely adaptable bioelectronic sensors
6. Proteins in African HIV strains interact differently with drugs
7. Proteins are vastly more complicated than previously realized
8. Life and death struggle: Proteins play against each other, bringing balance to immune system
9. Proteins that bind to sperm offer clues to male fertility and possible male contraception
10. Scientists Show Proteins Function Individually As Part Of DNA Repair
11. Genes Found That Label Cell Proteins For Disposal

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/6/2019)... CHICAGO (PRWEB) , ... June 05, 2019 , ... ... its role as the exclusive financial advisor to Pathologists Bio-Medical Laboratories (PBM) on ... is a preeminent anatomic pathology platform that provides services to more than one ...
(Date:6/4/2019)... , ... June 04, 2019 , ... Harper was three ... X-rays revealed severe elbow dysplasia, which caused painful osteoarthritis in the joints. ... Her parents were heartbroken. , The surgical specialist, Dr. Christopher Eich of ...
(Date:6/3/2019)... , ... June 03, 2019 , ... Stay on top ... medical device and food industries. Access to all webinars is free, so be sure ... in your field! , Visit http://www.xtalks.com to see our upcoming webinars: , ...
Breaking Biology News(10 mins):
(Date:6/18/2019)... ... June 18, 2019 , ... Personalized Stem Cells, Inc ... application to the FDA for use of a person’s own adipose-derived stem cells to ... osteoarthritis in the knee. This IND is the first of several planned clinical ...
(Date:6/11/2019)... ... June 10, 2019 , ... ... 80 of its scientific journals to DeepDyve’s rental service for peer-reviewed journals. ... expanding library of more than 20 million articles, sourced from more than 15,000 ...
(Date:6/6/2019)... ... June 05, 2019 , ... WCCT Global, Inc ... device industries, announced today that they will be receiving 3 awards at the 2019 ... WCCT received 2 awards in the categories of overall Quality and Compatibility (Access to ...
(Date:5/31/2019)... ... May 30, 2019 , ... Object Pharma, Inc., a startup ... of Metabiologics, Inc., a globally recognized leader in the production and sale of ... to a full spectrum of botulinum neurotoxins, as well as a CDC approved ...
Breaking Biology Technology:
Cached News: