Proteins transform DNA into 'molecular velcro'

the condensation reaction. When the researchers removed all excess ATP from the solution, they found that the condensin proteins continued to function. "That finding was a big surprise, because we expected the protein to be more like a motor that had to burn ATP every time it condensed," said Bustamante. Also, when they removed the excess protein from the solution, the bound protein was able to recondense the DNA when the tension on the DNA was lowered.

The researchers' analyses led them to propose a model of how the string of condensin proteins interacts to condense the DNA molecule. They theorize that the "heads" of the condensin proteins attach themselves sequentially and tightly to DNA. By attaching in this fashion, each protein "cooperates" with its neighbor, binding itself reversibly to the head of the next protein, thereby scrunching the DNA bit by bit into its condensed state. And when the researchers experimentally stretched the DNA molecule, the condensin heads popped apart sequentially, producing the sawtooth force extension pattern. But the heads remained bound to the DNA, so that when the force is lowered they can go back to their closed state and recondense the DNA molecule.

According to Bustamante, these studies of the bacterial condensin molecule will open the way to future studies of similar proteins that manipulate DNA and maintain chromosomal structure. "The actual mechanism by which these molecules actually carry out their function is unknown," he said. "And so, we are very excited that we have been able to develop an assay that, for the first time, gives us an understanding of how these molecules may be acting at the molecular level."


Contact: Jim Keeley
Howard Hughes Medical Institute

Page: 1 2 3

Related biology news :

1. Proteins show promise for mosquito control
2. Proteins may help identify patients who will respond better to treatments in certain cancers
3. Proteins enable HIV to override cells defenses
4. New Science Press launches Proteins: From Sequence to Structure
5. Report: Proteins can be engineered as widely adaptable bioelectronic sensors
6. Proteins in African HIV strains interact differently with drugs
7. Proteins are vastly more complicated than previously realized
8. Life and death struggle: Proteins play against each other, bringing balance to immune system
9. Proteins that bind to sperm offer clues to male fertility and possible male contraception
10. Scientists Show Proteins Function Individually As Part Of DNA Repair
11. Genes Found That Label Cell Proteins For Disposal

Post Your Comments:

(Date:6/1/2016)... June 1, 2016 Favorable Government ... Administration and Criminal Identification to Boost Global Biometrics System ... released TechSci Research report, " Global Biometrics Market ... Forecast and Opportunities, 2011 - 2021", the global biometrics ... 2021, on account of growing security concerns across various ...
(Date:5/16/2016)... 16, 2016   EyeLock LLC , a market ... opening of an IoT Center of Excellence in ... the development of embedded iris biometric applications. ... convenience and security with unmatched biometric accuracy, making it ... from DNA. EyeLock,s platform uses video technology to deliver ...
(Date:5/3/2016)... May 3, 2016  Neurotechnology, a provider of ... MegaMatcher Automated Biometric Identification System (ABIS) , a ... projects. MegaMatcher ABIS can process multiple complex biometric ... combination of fingerprint, face or iris biometrics. It ... and MegaMatcher Accelerator , which have ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... -- Sequenom, Inc. (NASDAQ: SQNM ), a life ... development of innovative products and services, announced today that ... denied its petition to review decisions by ... Patent No. 6,258,540 (",540 Patent") are not patent eligible ... Court,s Mayo Collaborative Services v. Prometheus Laboratories decision.  In ...
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading software ... Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio and ... clinical trial team. , Using the CONSULT module, patients and physicians can schedule a ...
(Date:6/27/2016)... Chapel Hill, N.C. (PRWEB) , ... June 27, ... ... of U.S. commercial operations for Amgen, will join the faculty of the ... will serve as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with ...
(Date:6/27/2016)... 27, 2016   Ginkgo Bioworks , a leading ... was today awarded as one of the World ... world,s most innovative companies. Ginkgo Bioworks is engineering ... real world in the nutrition, health and consumer ... with customers including Fortune 500 companies to design ...
Breaking Biology Technology:
Cached News: