Pufferfish DNA yields clues to hum...( genes in the human genome Aparicio s...)

genes in the human genome," Aparicio said. "In addition, direct comparisons of the fish DNA with the human DNA show that more human genes will be found by comparing fish with man. In this way, the pufferfish sequence is helping to find previously undiscovered features in the human genome sequence a process often compared to the decipherment of the Rosetta stone."

The study also revealed how the ordering of genes in genomes can be shuffled over time. Many small groups of genes are found in the same order in man and fish, but over longer distances the ordering of genes becomes scrambled. The rearrangements found by the researchers shed light on the processes that drive genome evolution.

The International Fugu Genome Consortium was formed in November 2000 by the JGI and the Singapore Biomedical Research Council's Institute for Molecular and Cell Biology. Other members of the consortium are the UK Medical Research Council's Human Genome Mapping Resource Centre in Cambridge, England, the Cambridge University Department of Oncology, and the Institute for Systems Biology in Seattle, Washington. Contributing to the consortium's sequencing efforts were two U.S. companies, Celera Genomics of Rockville, MD and Myriad Genetics, Inc., of Salt Lake City, UT.

JGI is a leader in sequencing organisms of crucial interest to researchers around the world. For the Human Genome Project, JGI sequenced human chromosomes 5, 16, and 19, which together constitute 11 percent of the human genome. JGI sequenced mouse DNA related to human chromosome 19 to illuminate the molecular evolutionary history of the two species. JGI has also sequenced the environmentally important white rot fungus (Phanerochaete chrysosporium) and nearly 50 important microorganisms.

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Contact: Charles Osolin
osolin1@llnl.gov
925-296-5643
DOE/Lawrence Livermore National Laboratory
25-Jul-2002

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