Pulmonary hypertension in newborns linked to nitric oxide ...( ee if we can block the development of p...)

ee if we can block the development of pulmonary hypertension in these babies," he said. In addition to the health benefits for the infants, the cost savings could be significant. Citrulline and arginine would cost only a few dollars per day compared to $3000 or more per day for nitric oxide treatment.

The relationship between urea cycle function and nitric oxide "has opened up a really new field," Summar said. He and Christman also are studying patients undergoing high dose chemotherapy for bone marrow transplantation. The complication of hepatic veno-occlusive disease appears to relate to nitric oxide levels and urea cycle function, Summar said.

With Dr. Rick Barr, assistant professor of Pediatrics and Anesthesiology, Summar is studying children who develop pulmonary hypertension following cardiac surgery. "It looks like the same phenomenon is happening here as well," he said. "It's like macroeconomics in a biological system," Summar said. "It's supply and demand-if you don't have a supply of materials to make nitric oxide when you have the demand for it, you run into trouble."

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Contact: John Howser
john.howser@mcmail.vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
13-Jun-2001

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