HOME >> BIOLOGY >> NEWS
Purdue developing less costly model for studying human disease

WEST LAFAYETTE, Ind. - A $1 million grant from the National Institutes of Health is helping Purdue University scientists move closer to making zebrafish the premier laboratory animal for studying human development and disease.

The goal of the three-year grant, which begins Aug. 1, is to create zebrafish in which a gene has been modified or permanently turned off, and the offspring inherit the alteration, said Paul Collodi, Department of Animal Sciences professor and senior researcher on the project. The progeny that possess the mutation are called knockouts. Once successfully produced in zebrafish, the knockouts will be used to study a gene's function.

The researchers are interested not just in making a genetic change, or mutation, in one fish, but also in its future generations, and more.

"The goal is to enable us to learn the role of specific genes in the zebrafish, which is an organism that is easy to study," Collodi said. "This information then can be applied to studying gene function that's involved in human disease and embryo development."

Currently knockouts are only possible in mice. Successfully duplicating the process in zebrafish would require much less time and money for researching gene function.

"The big problem in producing knockouts in species other than the mouse has been that it's been impossible to keep stem cells viable so that they contribute to the germ line, or eggs and sperm," Collodi said. "Now we have cells that we can grow for a long time in culture and they can still be transplanted into an embryo where they will become eggs or sperm."

The scientists discovered a way to keep altered embryonic stem cells from zebrafish alive long enough to pass on specific genetic changes. However they have not yet made a knockout using this technique. They currently are working to introduce a specific alteration into embryonic stem cells. It takes two generations to produce an adult fish with a specific ge
'"/>

Contact: Susan A. Steeves
ssteeves@purdue.edu
765-496-7481
Purdue University
28-Jul-2003


Page: 1 2 3

Related biology news :

1. Purdue study finds antioxidant protects metal-eating plants
2. Bright idea could doom cancer and viruses, say Purdue scientists
3. Purdue yeast makes ethanol from agricultural waste more effectively
4. IU and Purdue scientists to answer questions about Brood X periodical cicadas
5. Purdue scientists finding ways to outsmart crop-damaging bugs
6. Chestnut trees to spread across landscape again, says Purdue scientist
7. Purdue scientists: To stop cancer, keep your Icmt away from your Ras
8. Purdue chemists put the twist on protein building block
9. Purdue scientists: Genetically modified fish could damage ecology
10. Fat cells fight disease, Purdue University researchers find
11. Purdue chemist mussels in on secrets of natural adhesives

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... , April 24, 2017 Janice ... partner with  Identity Strategy Partners, LLP (IdSP) , ... or without President Trump,s March 6, 2017 ... Entry , refugee vetting can be instilled with greater ... (Right now, all refugee applications are suspended by ...
(Date:4/18/2017)... -- Socionext Inc., a global expert in SoC-based imaging and computing solutions, ... which features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ... will be showcased during the upcoming Medtec Japan at Tokyo Big ... Las Vegas Convention Center April 24-27. ... Click here for an image of ...
(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... NJ (PRWEB) , ... October 11, 2017 , ... Personal eye wash is a basic ... one eye at a time. So which eye do you rinse first if a dangerous ... have Plum Duo Eye Wash with its unique dual eye piece. , “Whether ...
(Date:10/11/2017)... ... 2017 , ... Proscia Inc ., a data solutions ... “Pathology is going digital. Is your lab ready?” with Dr. Nicolas Cacciabeve, Managing ... how Proscia improves lab economics and realizes an increase in diagnostic confidence.* ...
(Date:10/11/2017)... HILLS, Calif. , Oct. 11, 2017  SkylineDx today ... (ICR) and University of Leeds ... risk-stratify patients with multiple myeloma (MM), in a multi-centric Phase ... University of Leeds is the sponsor ... and ICR will perform the testing services to include high-risk ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study published in ... and fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched ... , After comparing the results from the fresh and frozen transfer cohorts, the ...
Breaking Biology Technology:
Cached News: