Purdue researchers develop new delivery system for ge...( West Lafayette IN For scientists wo...)

Purdue researchers develop new delivery system for gene therapy

West Lafayette, IN For scientists working to develop gene transfer and gene therapies, finding an ideal carrier system is half the battle. Current systems are often difficult to produce, and may target only a few cells or offer merely a temporary effect.

Purdue University researchers have combined the traits of two types of viruses to be used as a new delivery system that can carry genes into a wider range of cell types and provide a more stable transfer of genetic material.

The result is a delivery system with the potential for broad applications that may someday be used to treat cancer, diabetes and other diseases caused by an underlying genetic deficiency, says David Sanders, assistant professor of biological sciences at Purdue and the study's principal investigator. "This new system allows us to infiltrate different types of cells than is currently possible, thus increasing the types of tissues and organisms that we can treat using genetic therapies," Sanders says. The new virus delivery system also can be used by scientists to enhance studies on a group of viruses known as alphaviruses. Alphaviruses, including the Sindbis virus and Semliki Forest virus, are a family of viruses often transmitted to humans by insects and can cause neurological disease and arthritis. "These viruses are fairly difficult to study because they pose some health risks," Sanders says. "Also, because they kill cells, scientists were previously unable to study the process of how the virus enters the cell. This new delivery system has allowed us to separate the entry step from other steps of alphavirus replication."

Details of the study were published in the March issue of the Journal of Virology. Sanders and his Purdue colleague, Associate Professor Richard Kuhn, developed the new gene delivery system by replacing the outer protein shell of a virus, known as retrovirus, with the coat of an alphavirus. This combination virus is called a pseudotyped retrovirus because it infec
'"/>

Contact: Susan Gaidos
sgaidos@purdue.edu
765-494-2081
Purdue University
20-Mar-2001

Page: 1 2 3
Related biology news :

1. Purdue study finds antioxidant protects metal-eating plants
2. Bright idea could doom cancer and viruses, say Purdue scientists
3. Purdue yeast makes ethanol from agricultural waste more effectively
4. IU and Purdue scientists to answer questions about Brood X periodical cicadas
5. Purdue scientists finding ways to outsmart crop-damaging bugs
6. Chestnut trees to spread across landscape again, says Purdue scientist
7. Purdue scientists: To stop cancer, keep your Icmt away from your Ras
8. Purdue chemists put the twist on protein building block
9. Purdue scientists: Genetically modified fish could damage ecology
10. Fat cells fight disease, Purdue University researchers find
11. Purdue chemist mussels in on secrets of natural adhesives

Post Your Comments:

(Date:11/25/2009)...you eat may be just as vital to your health as wha... for Biological Studies. Their experiments in mice...sands of genes in the liverthe body,s metabolic cl... not by the body,s circadian clock as conventional...he activity of a large number of genes completely ...

(Date:11/24/2009)...pening new doors to understanding how sounds assoc...a marine mammal or if they hear it at all. , Th...rs that NASA uses to detect flaws in the space shu... scientists to peek inside the giant head of a wha...onal replicas of a whale,s hearing anatomy using a...

(Date:11/24/2009)...tion of a remarkable class of ring-shaped protein ...Lawrence Berkeley National Laboratory (Berkeley La...y beamline at the Advanced Light Source (ALS). The...ssion and replication, and are vital to the surviv...agents, such as the human papillomavirus, which ha...

Breaking Biology News(10 mins):Feeding the clock 2 Feeding the clock 3 Rocket science leads to new whale discovery 2 Atomic-level snapshot catches protein motor in action 2 Atomic-level snapshot catches protein motor in action 3 Atomic-level snapshot catches protein motor in action 4 Dilon Diagnostics Joins Forces With Philips for Womens Health Solutions 5368 1 Dilon Diagnostics Joins Forces With Philips for Womens Health Solutions 5368 2 Dilon Diagnostics Joins Forces With Philips for Womens Health Solutions 5368 3 17th International Process Development Conference to Feature Presentations on Safety Process Development Crystallization PAT Scale Up and Producti 14423 1 17th International Process Development Conference to Feature Presentations on Safety Process Development Crystallization PAT Scale Up and Producti 14423 2 Is London Heading For a Water Crunch 3F 59261 1 Is London Heading For a Water Crunch 3F 59261 2 Is London Heading For a Water Crunch 3F 59261 3 Is London Heading For a Water Crunch 3F 59261 4

[0] Feeding the clock [1] Rocket science leads to new whale discovery [1] Atomic-level snapshot catches protein motor in action

(Date:11/24/2009)...FirstCall/--IES(Nasdaq: IESC ),aleadingnationalpro...esforthecommercial,industrialandresidentialmarkets...enawardedacontractfromManhattanTorconJVtoinstallth...replacementfacilityattheU.S.ArmyMedicalResearchIns...nFrederick,Md. ,, ThenewUSAMRIIDreplacementfaci...

(Date:11/24/2009)...York investment bank KTA Capital,s client Neuren P...mil convertible note private placement with a U.S.... arranged by KTA Capital as Neuren,s exclusive pla... New York (PRWEB) November 23, 2009 -- The indep..."KTA Capital") has announced that its cl...

(Date:11/24/2009)...,Nov.24/PRNewswire-FirstCall/--DowAgroSciencesCana...s,adivisionofThompsonsLimitedofBlenheim,Ontario.Th...nces,currentseedsbusinessasthecompanyanticipatesth...SciencesHerbicideTolerantTraitTechnologyincornin20... ,, "Thisacquisitionbringstogethertwostrongprog...

(Date:11/24/2009)...-FirstCall/--Sigma-AldrichCorporation(Nasdaq: SIAL...y,December1stat1:45PMGMTinLondon,7:45AMUS/CST.Inte...Internetavailableat http://inve s tor.sig m a...accessthisfile. ,, AboutSigma-Aldrich: Sigma...any.Itschemicalandbiochemicalproductsandkitsareuse...

Breaking Biology Technology:Integrated Electrical Services Awarded Contract to Provide Electrical Systems for U.S. Army Medical Research Institute of Infectious Diseases 2 KTA Capital Arranges an AU$6.7 Million Private Placement by Neuren Pharmaceuticals 2 Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 2 Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 3

[0] Integrated Electrical Services Awarded Contract to Provide Electrical Systems for U.S. Army Medical Research Institute of Infectious Diseases [0] KTA Capital Arranges an AU$6.7 Million Private Placement by Neuren Pharmaceuticals [0] Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds [0] Sigma-Aldrich to Present at the NASDAQ OMX 23rd Investor Program on Tuesday, December 1, 2009

Other News:

...udy by U of T researchers suggests that front-line...on, Ont., and North Battleford, Sask., were not so...y the researchers, water contamination resulted fr...kers, local governments, regulatory bodies and pro...

... IL (April 29, 2003) - Researchers at Children's H...ue engineering of the penis, raising hopes that me...rgery, cancer, congenital malformations or other c...unction.......These findings, presented at the Ame...

The genome sequence of the bread mold Neurospora crassa has been revealed by a group of 77 researchers from seven nations, among them Prof. Oded Yarden of the Hebrew University of Jerusalem Faculty of

...E, Calif. -- April 30, 2003 -- In the April 24, 20...ding UC Riverside's Katherine A. Borkovich, assist..., and her postdoctoral fellow, Svetlana Krystofova...urospora genome. (A genome is all the DNA in an o...

System failure to blame for Walkerton, North Battleford outbreaks, says U of T study 2 System failure to blame for Walkerton, North Battleford outbreaks, says U of T study 3 Tissue engineering for erectile dysfunction? 2 Genome sequence of bread mold revealed by international team, including Hebew University researcher 2 UC Riverside scientists contribute to study that unveils genome sequence of bread mold 2 UC Riverside scientists contribute to study that unveils genome sequence of bread mold 3

System failure to blame for Walkerton, North Battleford outbreaks, says U of T study Tissue engineering for erectile dysfunction?Genome sequence of bread mold revealed by international team, including Hebew University researcher UC Riverside scientists contribute to study that unveils genome sequence of bread mold

...sity of California, Santa Barbara, has been chosen...iversity research efforts as a Program of Excellen...onal Heart, Lung and Blood Institute of the Nation...rategy to accelerate progress in medical research ...

New Haven, Conn. -- Free protons from acids associate with 1, 2 or 3 molecules of water and the structures can be identified by unique infrared laser spectrum signatures, according to a report in Scie

Researchers at the University of Minnesota were able to reverse memory loss in mice with significant brain degeneration for the first time, a breakthrough that offers hope to the estimated 4 million p

...de girls overtly ignore another little girl unders...ial aggression can inflict upon others. Now a stu...al Child Development finds that this form of aggre..., is related more to a child's environment than to...

UCSB chosen for two NIH Program of Excellence (PEN) in nanotechnology grants 2 Identifying the 'signatures' of protons in water 2 U of MN researchers reverse memory loss in mice 2 Environment more than genes determines child's social aggressiveness 2

UCSB chosen for two NIH Program of Excellence (PEN) in nanotechnology grants Identifying the 'signatures' of protons in water U of MN researchers reverse memory loss in mice Environment more than genes determines child's social aggressiveness