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Purdue team solves structure of West Nile virus

other."

This closer look represents the next step for Purdue's structural virology group, which has recently received new support from the National Institutes of Health in the form of grants totaling nearly $18 million. These grants support basic research on viral infectious diseases, including West Nile.

"We currently have a 17-angstrom resolution structure," Kuhn said. "We hope to use our NIH support to get down to the 9-angstrom scale or better, as this would give us details on the individual protein molecules as well as other proteins in the virus."

The work on the West Nile virus was performed by Suchetana Mukhopadhyay, Bong-Suk Kim and Paul R. Chipman, who are associated with the labs of Rossmann and Kuhn. The group is part of the Markey Center for Structural Biology, which consists of laboratories that use a combination of cryoelectron microscopy, crystallography, nuclear magnetic resonance, biochemistry and molecular biology to elucidate the processes of viral entry, replication and pathogenesis. Approximately 100 research scientists, including 50 graduate students, comprise the Markey Center.


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Contact: Chad Boutin
cboutin@purdue.edu
765-494-2081
Purdue University
9-Oct-2003


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