HOME >> BIOLOGY >> NEWS
Putting microRNAs in their place

Scientists have discovered a novel protein complex that may help shed light on the function of a newly discovered class of small RNAs, as well as a common hereditary neurodegenerative disease.

An international research group, headed by Dr. Gideon Dreyfuss at UPENN School of Medicine, has successfully identified 31 novel very small RNAs, called microRNAs (miRNAs), and the protein complex that houses them. By identifying the protein components of this complex, the scientists were able to infer potential functions for the miRNAs with which they are associated.

RNA transcripts do not exist as free molecules in the cell nucleus. Rather, RNAs exist in human cells as part of large ribonucleoprotein particles (RNPs) that contain various proteins.

miRNAs have received considerable attention lately, owing to the realization of their widespread evolutionary distribution, and their similarity to other classes of small RNAs (approximately 22 nucleotides long) that are critical components of RNA interference and developmental gene regulation. Although over 100 miRNAs have been identified in organisms ranging from roundworms, to fruit flies, to humans, no one is quite sure what function they serve.

Dr. Dreyfuss work is providing some solid cues.

Dr. Dreyfuss and colleagues found that the main protein components of the miRNPs are: a eukaryotic translation initiation factor, eIF2C2, and previously identified components of the Survival of Motor Neurons (SMN) complex, Gemin3 and Gemin4.

The presence of eIF2C2, an Argonaute protein family member, in miRNPs confirms existing data implicating Argonaute proteins in small RNA function. The presence of Gemin3 and 4, though, was a bit more surprising. The SMN complex is named for one of its main constituents, the Survival of Motor Neurons protein, which, when mutated results in spinal muscular atrophy, the second most common childhood neuromuscular disorder.

This finding of shared co
'"/>

Contact: Nora Poppito
poppito@cshl.org
Cold Spring Harbor Laboratory
14-Mar-2002


Page: 1 2

Related biology news :

1. Putting energy into heart protection
2. Putting GPS to work, researchers shed light on road-following by pigeons
3. Putting genes in a pill
4. Putting randomness to work: unique form of nanoscale random motion may drive key cellular functions
5. Putting muscle in the nucleus
6. Putting muscle in the nucleus
7. Putting a price tag on paradise
8. Putting medical research on-line to give patients the information they need
9. Putting Doesnt Pollute, Research Finds
10. Putting A Price Tag On Pollution
11. Putting Down Your Roots: How Plants Know To Do It

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/9/2016)... attendance control systems is proud to announce the introduction of fingerprint attendance control software, ... employees are actually signing in, and to even control the opening of doors. ... ... ... Photo - http://photos.prnewswire.com/prnh/20160609/377487 ...
(Date:6/7/2016)... 2016  Syngrafii Inc. and San Antonio Credit ... includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution ... will result in greater convenience for SACU members ... maintaining existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of ... the Cary 5000 and the 6000i models are higher end machines that use the ... of the spectrophotometer’s light beam from the bottom of the cuvette holder. , ...
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute approval ... of microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the ... the Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s ... how hardware projects are designed, built and brought to market. , The Design ...
Breaking Biology Technology:
Cached News: