HOME >> BIOLOGY >> NEWS
Putting microRNAs in their place

Scientists have discovered a novel protein complex that may help shed light on the function of a newly discovered class of small RNAs, as well as a common hereditary neurodegenerative disease.

An international research group, headed by Dr. Gideon Dreyfuss at UPENN School of Medicine, has successfully identified 31 novel very small RNAs, called microRNAs (miRNAs), and the protein complex that houses them. By identifying the protein components of this complex, the scientists were able to infer potential functions for the miRNAs with which they are associated.

RNA transcripts do not exist as free molecules in the cell nucleus. Rather, RNAs exist in human cells as part of large ribonucleoprotein particles (RNPs) that contain various proteins.

miRNAs have received considerable attention lately, owing to the realization of their widespread evolutionary distribution, and their similarity to other classes of small RNAs (approximately 22 nucleotides long) that are critical components of RNA interference and developmental gene regulation. Although over 100 miRNAs have been identified in organisms ranging from roundworms, to fruit flies, to humans, no one is quite sure what function they serve.

Dr. Dreyfuss work is providing some solid cues.

Dr. Dreyfuss and colleagues found that the main protein components of the miRNPs are: a eukaryotic translation initiation factor, eIF2C2, and previously identified components of the Survival of Motor Neurons (SMN) complex, Gemin3 and Gemin4.

The presence of eIF2C2, an Argonaute protein family member, in miRNPs confirms existing data implicating Argonaute proteins in small RNA function. The presence of Gemin3 and 4, though, was a bit more surprising. The SMN complex is named for one of its main constituents, the Survival of Motor Neurons protein, which, when mutated results in spinal muscular atrophy, the second most common childhood neuromuscular disorder.

This finding of shared co
'"/>

Contact: Nora Poppito
poppito@cshl.org
Cold Spring Harbor Laboratory
14-Mar-2002


Page: 1 2

Related biology news :

1. Putting energy into heart protection
2. Putting GPS to work, researchers shed light on road-following by pigeons
3. Putting genes in a pill
4. Putting randomness to work: unique form of nanoscale random motion may drive key cellular functions
5. Putting muscle in the nucleus
6. Putting muscle in the nucleus
7. Putting a price tag on paradise
8. Putting medical research on-line to give patients the information they need
9. Putting Doesnt Pollute, Research Finds
10. Putting A Price Tag On Pollution
11. Putting Down Your Roots: How Plants Know To Do It

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/8/2016)... , March 8, 2016   Valencell ... technology, today announced it has secured $11M in ... GII Tech, a new venture fund being launched ... additional participation from existing investors TDF Ventures and ... funds to continue its triple-digit growth and accelerate ...
(Date:3/3/2016)... MONTEREY, Calif. , March 3, 2016 /PRNewswire/ ... Partner, launched this week highlighting advancements in flexible, ... – a record setting attendance - have gathered ... in this fast-growing field of electronics. The Flex ... a focal point for companies, R&D organizations, and ...
(Date:3/2/2016)... March 2, 2016 ... addition of the  "Global Biometrics Market in ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , Global biometrics ... at a CAGR of around 27%   ... has announced the addition of the  "Global ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... N.J. , May 4, 2016  Bayer ... its oncology compound Stivarga ® (regorafenib) tablets ... carcinoma (HCC) has met its primary endpoint of ... study, called RESORCE, evaluated the efficacy and safety ... has progressed after treatment with sorafenib. The safety ...
(Date:5/4/2016)... New York, NY (PRWEB) , ... May 04, ... ... growth, has leveraged recent innovations in biotechnology to help treat hormonal and stress ... hair loss, Nutrafol® has captured the hearts of key opinion leaders in the ...
(Date:5/3/2016)... ... 03, 2016 , ... Leading CEOs from biotech, pharmaceutical, and ... June 1st at The Four Seasons Hotel Boston. , The Boston CEO Conference ... exclusive access to key decision makers who influence deal making and investment. Attendees ...
(Date:5/3/2016)... -- - And Other Rising Companies - ... Competitor Biologics  - Biosimilar Drug Producers - ... Who are the most important and promising ... sales potentials? Discover, in our updated survey, organisations, outlooks ... revenue forecasting. Visiongain,s new study ...
Breaking Biology Technology:
Cached News: