HOME >> BIOLOGY >> NEWS
Putting microRNAs in their place

Scientists have discovered a novel protein complex that may help shed light on the function of a newly discovered class of small RNAs, as well as a common hereditary neurodegenerative disease.

An international research group, headed by Dr. Gideon Dreyfuss at UPENN School of Medicine, has successfully identified 31 novel very small RNAs, called microRNAs (miRNAs), and the protein complex that houses them. By identifying the protein components of this complex, the scientists were able to infer potential functions for the miRNAs with which they are associated.

RNA transcripts do not exist as free molecules in the cell nucleus. Rather, RNAs exist in human cells as part of large ribonucleoprotein particles (RNPs) that contain various proteins.

miRNAs have received considerable attention lately, owing to the realization of their widespread evolutionary distribution, and their similarity to other classes of small RNAs (approximately 22 nucleotides long) that are critical components of RNA interference and developmental gene regulation. Although over 100 miRNAs have been identified in organisms ranging from roundworms, to fruit flies, to humans, no one is quite sure what function they serve.

Dr. Dreyfuss work is providing some solid cues.

Dr. Dreyfuss and colleagues found that the main protein components of the miRNPs are: a eukaryotic translation initiation factor, eIF2C2, and previously identified components of the Survival of Motor Neurons (SMN) complex, Gemin3 and Gemin4.

The presence of eIF2C2, an Argonaute protein family member, in miRNPs confirms existing data implicating Argonaute proteins in small RNA function. The presence of Gemin3 and 4, though, was a bit more surprising. The SMN complex is named for one of its main constituents, the Survival of Motor Neurons protein, which, when mutated results in spinal muscular atrophy, the second most common childhood neuromuscular disorder.

This finding of shared co
'"/>

Contact: Nora Poppito
poppito@cshl.org
Cold Spring Harbor Laboratory
14-Mar-2002


Page: 1 2

Related biology news :

1. Putting energy into heart protection
2. Putting GPS to work, researchers shed light on road-following by pigeons
3. Putting genes in a pill
4. Putting randomness to work: unique form of nanoscale random motion may drive key cellular functions
5. Putting muscle in the nucleus
6. Putting muscle in the nucleus
7. Putting a price tag on paradise
8. Putting medical research on-line to give patients the information they need
9. Putting Doesnt Pollute, Research Finds
10. Putting A Price Tag On Pollution
11. Putting Down Your Roots: How Plants Know To Do It

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/18/2016)... Calif. , Jan. 18, 2016  Extenua ... software that simplifies the use and access of ... and go-to-market partnership with American Cyber.  ... brings extensive experience leading transformational C4ISR and Cyber ... and integrating the latest proven technology solutions," said ...
(Date:1/13/2016)... 2016 --> ... market report titled - Biometric Sensors Market - Global Industry ... 2023. According to the report, the global biometric sensors market was valued ... reach US$1,625.8 mn by 2023, expanding at a CAGR ... volume, the biometric sensors market is expected to reach ...
(Date:1/11/2016)... SAN JOSE, Calif. , Jan. 11, 2016 /PRNewswire/ ... developer of human interface solutions, today announced that its ... display driver integration (TDDI) products won two separate categories ... including Best Mobile Innovator and Best Technology Breakthrough. The ... overall system cost, a simplified supply chain, thinner devices, ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... NX Prenatal Inc., a US based ... for early warning of adverse pregnancy outcomes, announced ... by Dr. Thomas McElrath of Brigham ... Medicine,s (SMFM) annual meeting held in ... The presentation reported initial positive top-line results regarding ...
(Date:2/10/2016)... 2016  Allergan plc (NYSE: AGN ) a ... Saunders , Allergan,s CEO and President, will be featured ... at the RBC Capital Markets Healthcare Conference on Tuesday, ... New York Palace Hotel in New York, ... and can be accessed on Allergan,s Investor Relations web ...
(Date:2/10/2016)... ... February 10, 2016 , ... LATHAM, NEW YORK... Marktech ... SPIE Photonics West conference in San Francisco’s Moscone Center from February 16-18, 2016, ... venue. , These latest InGaAs PIN diode standard packages feature a TO-46 metal ...
(Date:2/10/2016)... FL (PRWEB) , ... February 10, 2016 , ... ... in regenerative medicine, has announced a new agreement with Singapore-based Global Stem Cells ... physicians from the Philippines, Thailand and Singapore in the latest adipose and bone ...
Breaking Biology Technology:
Cached News: