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Putting muscle in the nucleus

Scientists have long pondered how, inside the nucleus of a cell, long stretches of DNA are moved through the huge enzyme factories that transcribe DNA's genetic information into messages made of RNA. Now, for the first time, a team of scientists from the University of Illinois at Chicago has demonstrated the presence of a "molecular motor" inside the nucleus, where it appears to be powering the assembly line that forges RNA messages off of the long DNA templates. The finding is reported in the Oct. 13 issue of the journal Science.

The motor molecule, called myosin-1, is a close chemical relative of the myosin responsible for muscle contraction.

"When your heart beats, when you take a breath, when you digest food or have a baby - anytime cells move or divide - myosin is involved," says Primal de Lanerolle, professor of physiology and biophysics at UIC, who led the team.

Myosin, well known since the 1920s, is a protein found in the cytoplasm of nearly every type of cell in the body. It had never before been found in the nucleus. DNA, on the other hand, resides in the nucleus, where it is transcribed into the RNA messages that then travel to the cytoplasm to guide the synthesis of the proteins - like myosin - that do all the work of the cell.

Despite the fact that transcribing DNA is itself prodigious work, many scientists did not believe that myosin existed in the nucleus - indeed, no motor molecule had ever been found there. "We had an uphill battle to convince our colleagues," de Lanerolle said.

His team convincingly demonstrated myosin-1 in the nucleus. They also showed that this myosin fits together closely with a key component of the transcription machinery and that it plays an active role in making RNA.

The discovery is important for several reasons, de Lanerolle said. "It offers insight into the DNA transcription process at the molecular level and shows that transcription and muscle contraction have certain similarities. Consequent
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Contact: Bill Burton
burton@uic.edu
312-996-2269
University of Illinois at Chicago
12-Oct-2000


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