HOME >> BIOLOGY >> NEWS
Putting randomness to work: unique form of nanoscale random motion may drive key cellular functions

of a phosphate -- releases from the microtubule.
  • ATP hydrolysis makes the switch mechanism irreversible. Though ATP normally provides energy for macromolecular synthesis, Fox argues that in motor proteins ATP performs a switching role, changing the protein conformation and its binding affinity.
  • The unbound head -- just 5-7 nanometers in diameter -- is moved about randomly by Brownian motion in the cellular fluid until it encounters a new site where it can bind. Reported in the early 1800s by biologist Robert Brown, Brownian motion is the irregular activity of tiny particles suspended in a fluid. It results from the thermally driven movement of molecules in a fluid, the velocity of the particles depending on the temperature temperature.
  • Because of structural limits in the kinesin and spacing of binding sites on the microtubules, the moving head can reach only one possible binding site -- 8 nanometers past the bound head, which temporarily remains attached to the microtubule.
  • The head binds to the new site, moving the kinesin and its cargo about 8 nanometers along the microtubule.
  • The process quickly starts anew with the original two heads in interchanged positions.
  • "Normally, Brownian motion cannot do anything concerted or with directionality, because it is random," Fox explained. "But what happens here is a random process in a system that has asymmetric boundary conditions created by the ATP switching. That makes it possible to get a net directed motion along the microtubule."

    The model described by Fox and post-doctoral colleague Mee Hyang Choi depends on two unique properties of structures at the nanometer-scale: thermal energy can be a robust source of power, and random motion occurs very rapidly.

    "Normally, we would t
    '"/>

    Contact: John Toon
    john.toon@edi.gatech.edu
    404-894-6986
    Georgia Institute of Technology Research News
    3-Jun-2001


    Page: 1 2 3 4

    Related biology news :

    1. Putting energy into heart protection
    2. Putting GPS to work, researchers shed light on road-following by pigeons
    3. Putting genes in a pill
    4. Putting microRNAs in their place
    5. Putting muscle in the nucleus
    6. Putting muscle in the nucleus
    7. Putting a price tag on paradise
    8. Putting medical research on-line to give patients the information they need
    9. Putting Doesnt Pollute, Research Finds
    10. Putting A Price Tag On Pollution
    11. Putting Down Your Roots: How Plants Know To Do It

    Post Your Comments:
    *Name:
    *Comment:
    *Email:


    (Date:4/13/2017)... 13, 2017 According to a new market research ... Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and ... is expected to grow from USD 14.30 Billion in 2017 to USD ... 17.3%. ... MarketsandMarkets Logo ...
    (Date:4/6/2017)... LONDON , April 6, 2017 ... Control, RFID, ANPR, Document Readers, by End-Use (Transportation & ... Energy Facility, Oil, Gas & Fossil Generation Facility, Nuclear ... Healthcare, Educational, Other) Are you looking for ... Authentication sector? ...
    (Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
    Breaking Biology News(10 mins):
    (Date:10/12/2017)... , ... October 12, 2017 , ... ... with the pharmaceutical and biotechnology industries to improve patient outcomes and quality of ... trends in analytical testing are being attributed to new regulatory requirements for all ...
    (Date:10/11/2017)... Palo Alto, CA, USA (PRWEB) , ... October 11, 2017 , ... ... is set to take place on 7th and 8th June 2018 in San Francisco, ... and policy influencers as well as several distinguished CEOs, board directors and government officials ...
    (Date:10/11/2017)... ... October 11, 2017 , ... A new study ... in frozen and fresh in vitro fertilization (IVF) transfer cycles. The ... IVF success. , After comparing the results from the fresh and frozen transfer ...
    (Date:10/10/2017)... ... ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. spent ... entitled “Stem Cells and Their Regenerative Powers,” was held on August 31st, 2017 ... joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic Surgery, Grossmont ...
    Breaking Biology Technology:
    Cached News: