HOME >> BIOLOGY >> NEWS
Putting randomness to work: unique form of nanoscale random motion may drive key cellular functions

of a phosphate -- releases from the microtubule.
  • ATP hydrolysis makes the switch mechanism irreversible. Though ATP normally provides energy for macromolecular synthesis, Fox argues that in motor proteins ATP performs a switching role, changing the protein conformation and its binding affinity.
  • The unbound head -- just 5-7 nanometers in diameter -- is moved about randomly by Brownian motion in the cellular fluid until it encounters a new site where it can bind. Reported in the early 1800s by biologist Robert Brown, Brownian motion is the irregular activity of tiny particles suspended in a fluid. It results from the thermally driven movement of molecules in a fluid, the velocity of the particles depending on the temperature temperature.
  • Because of structural limits in the kinesin and spacing of binding sites on the microtubules, the moving head can reach only one possible binding site -- 8 nanometers past the bound head, which temporarily remains attached to the microtubule.
  • The head binds to the new site, moving the kinesin and its cargo about 8 nanometers along the microtubule.
  • The process quickly starts anew with the original two heads in interchanged positions.
  • "Normally, Brownian motion cannot do anything concerted or with directionality, because it is random," Fox explained. "But what happens here is a random process in a system that has asymmetric boundary conditions created by the ATP switching. That makes it possible to get a net directed motion along the microtubule."

    The model described by Fox and post-doctoral colleague Mee Hyang Choi depends on two unique properties of structures at the nanometer-scale: thermal energy can be a robust source of power, and random motion occurs very rapidly.

    "Normally, we would t
    '"/>

    Contact: John Toon
    john.toon@edi.gatech.edu
    404-894-6986
    Georgia Institute of Technology Research News
    3-Jun-2001


    Page: 1 2 3 4

    Related biology news :

    1. Putting energy into heart protection
    2. Putting GPS to work, researchers shed light on road-following by pigeons
    3. Putting genes in a pill
    4. Putting microRNAs in their place
    5. Putting muscle in the nucleus
    6. Putting muscle in the nucleus
    7. Putting a price tag on paradise
    8. Putting medical research on-line to give patients the information they need
    9. Putting Doesnt Pollute, Research Finds
    10. Putting A Price Tag On Pollution
    11. Putting Down Your Roots: How Plants Know To Do It

    Post Your Comments:
    *Name:
    *Comment:
    *Email:


    (Date:5/24/2016)... 24, 2016 Ampronix facilitates superior patient care by providing unparalleled technology to ... display is the latest premium product recently added to the range of products distributed ... ... ... Imaging- LCD Medical Display- Ampronix News ...
    (Date:5/16/2016)... 16, 2016   EyeLock LLC , a market ... opening of an IoT Center of Excellence in ... the development of embedded iris biometric applications. ... convenience and security with unmatched biometric accuracy, making it ... from DNA. EyeLock,s platform uses video technology to deliver ...
    (Date:5/9/2016)... -- Elevay is currently known as the ... high net worth professionals seeking travel for work   ... there is still no substitute for a face-to-face meeting. ... deal with a firm handshake. This is why wealthy ... citizenship via investment programs like those offered by the ...
    Breaking Biology News(10 mins):
    (Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... the release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” ... and retention in this eBook by providing practical tips, tools, and strategies for ...
    (Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
    (Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. ... test has received AOAC Research Institute approval 061601. , “This is another AOAC-RI ... stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate ...
    (Date:6/23/2016)... June 23, 2016   EpiBiome , a precision ... million in debt financing from Silicon Valley Bank (SVB). ... and to advance its drug development efforts, as well ... "SVB has been an incredible strategic partner ... a traditional bank would provide," said Dr. Aeron ...
    Breaking Biology Technology:
    Cached News: