HOME >> BIOLOGY >> NEWS
Quality Control System Ensures Genetic Instructions Are Ready To Go

MADISON, Wis. -- Cells pay even closer attention to quality control of genetic information than scientists previously thought, according to new findings by University of Wisconsin Medical School researchers. Before sending genetic molecules out of the nucleus to sites where they will ultimately function, cells check to see that they are complete and ready to go.

"With this finding, we can start to think of the nuclear envelope as more than a shell that keeps the components of the nucleus together," said UW Medical School Professor of Biomolecular Chemistry Dr. James Dahlberg. "We now know it's also a barrier that makes sure genetic material isn't exported prematurely from the nucleus, which could be disastrous for the cell."

Dahlberg, a member of the National Academy of Sciences, and Elsebet Lund, a senior scientist in the department of biomolecular chemistry, report their findings in the Dec. 11 issue of the journal Science.

Proteins, essential for all life processes, are made up of building blocks of amino acids arranged in specific sequences determined by genetic instructions. The machinery that builds the proteins involves a special molecule called transfer RNA (tRNA), which delivers the amino acids to protein-assembly factories known as ribosomes.

After several years of studying mechanisms by which molecules are transported in and out of the nucleus, Dahlberg and Lund recently asked how cells determine exactly when tRNA is able to function. In their experiments, they showed that each tRNA must be able to attach its amino acid before it is exported from the nucleus.

"Like a last-minute quality-control check on the loading dock, this system may be the way the cell says, 'Yes, you're ready to be sent out to the ribosome,'" he said.

The quality-control process, known as proofreading, works in many areas of biology, but was never known to occur in tRNA export until the UW experiments.

In their studies, the researchers first made th
'"/>

Contact: Dian Land
dianland@macc.wisc.edu
608-263-9893
University of Wisconsin-Madison
10-Dec-1998


Page: 1 2

Related biology news :

1. Quality of herbal remedies often is guesswork, expert says
2. Water Quality In Georgia-Florida Coastal Plain Affected By Agricultural And Urban Activities
3. USGS Says Central Columbia Plateau Water Quality Impaired by Agriculture, But Some Good News
4. From The Home Front To The River Front, USGS Updates Water-Quality Information
5. Water Quality In Indianas White River Basin Affected By Urban And Agricultural Activities
6. Link Made Between Human Growth Hormone, Bone Quality In Mice
7. Ozone Chat Room Provides Real-Time Air-Quality Research
8. Controlling biomolecules with magnetic tweezers
9. Controlling the internal clock in darkness
10. Controlling body size by regulating the number of cells
11. Controlling cell adhesion: Researchers report first evidence of catch bonds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/5/2020)... ... ... Greffex, a pioneering vaccine and gene therapy company based in Houston, Texas, welcomes ... a global perspective to make an impact in a post pandemic world,” said Co-Chairman ... independent, director of the company. , “The Greffex board is excited to have Neil ...
(Date:5/30/2020)... ... May 29, 2020 , ... eInfochips, a leading provider of ... with EchoNous Inc. to develop the cloud-based connected health KOSMOS platform that has ... has been clinically tested versus expert measurements, yielding improved results in precision and ...
(Date:5/28/2020)... (PRWEB) , ... May 27, 2020 , ... ... hc1 Workforce Advisor™ , a solution that uniquely combines lab testing insights ... help employers systematically support the ongoing health and safety of employees returning to ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... ... June 29, 2020 , ... The ... purchasing contracts to its membership, recently named BioFit Engineered Products an ... opportunity to purchase ergonomic seating, cafeteria tables, book trucks and carts at discounted ...
(Date:6/28/2020)... ROCKY HILL, Conn. (PRWEB) , ... June 25, ... ... systems company formed to advance photodynamic therapy for treating cancer, today announced the ... Buffalo, New York (“Roswell Park”). The agreement provides Lumeda globally exclusive rights ...
(Date:6/23/2020)... ... 22, 2020 , ... Regen Suppliers, the one stop shop ... three, get the fourth unit free with no limit on the amniotic derived ... exosomes, have been a game changer for regenerative therapies. The products are manufactured ...
(Date:6/11/2020)... ... 08, 2020 , ... Greffex, a leading genetic engineering company, ... clean viral vectors, recently announced a key manufacturing agreement with FUJIFILM Diosynth Biotechnologies ... world’s most successful gene therapy delivery vehicle (vector) with broad applications for delivering ...
Breaking Biology Technology:
Cached News: