Quality Control System Ensures Genetic Instructions Are Ready To Go

e unexpected discovery that amino acids can attach to tRNA in the nucleus, not just outside it in the cytoplasm. They then showed that amino acid attachment is required for efficient delivery of the tRNA out of the nucleus.

"This told us the cell really does monitor whether the tRNA can function before it is released into the cytoplasm," he said.

Dahlberg said it behooves cells to ensure tRNA molecules don't leave the nucleus before they're fully matured with amino acids attached. He noted that once they're out, there's no way back for further maturation.

"Immature tRNA can cause a big mess in protein assembly," he said.


Contact: Dian Land
University of Wisconsin-Madison

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