Quark Biotech generates a cholesterol-free mouse

Fremont, CA - December 18, 2003 - Quark Biotech, Inc. (QBI) today announced the publication in the prestigious peer reviewed scientific journal, Science, the results of a study of mice that contain virtually no cholesterol. The study was conducted together with scientists from the Karolinska Institute in Sweden and the Sackler School of Medicine in Israel. This mouse strain was created by disrupting the gene Dhcr24, which encodes the enzyme called desmosterol reductase and appears to be responsible for the last step in the biosynthesis of cholesterol, a sterol that is an indispensable structural block of cells and their membranes and plays major roles in signal transduction. The paper entitled "Generation of Viable Cholesterol-Free Mice," appears in Science, December 19, 2003 (Vol. 302, Page 2087).

"We were surprised by the fact that a mouse lacking cholesterol can survive and develop into adulthood with little effect, when cholesterol accounts for approximately 99% of all steroids in mammals," commented Dr. Elena Feinstein, VP of Technology Development at Quark Biotech and senior author of the study. "We believe that this mouse can become a highly resourceful tool to further understand the role of cholesterol in the different organs. This knowledge can in the future help discover novel drugs and understand the mechanism of action of existing drugs for metabolic diseases and cancer, among others."

The study supports for the first time in a complex organisms model the "sterol synergism" theory, which points out the interchangeability of certain sterols, that up to now had only been shown in simple models such as yeast. However, the research conducted suggests the importance of cholesterol in the developmental stages, particularly during embryogenesis. Furthermore, the knock-out pups appeared to be smaller in size and showed poorer growth characteristics than the normal animals.

Dr. Daniel Zurr, CEO of Quark Biotech said, "Quark initiat

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