RNA editing process plays essential role in embryo development

In a new study, scientists at The Wistar Institute report the first direct evidence that RNA editing is essential to mammalian embryo development. RNA editing is a normal but not yet fully understood process in which small nucleotide changes occur after DNA has been transcribed into RNA. The process makes it possible for one gene to be translated into multiple proteins with different structures or functions.

The researchers repeatedly attempted to delete, or knock out, in mice a gene known to be involved in RNA editing called ADAR1 in order to study its function. Certain target genes in the brain are known to be subjected to RNA editing by the ADAR1 enzyme, including glutamate receptor ion channels, critical for memory formation, and serotonin receptors, which regulate emotional behaviors. The investigators expected that deletion of the ADAR1 gene would therefore lead to significant changes in brain functions.

Unexpectedly, however, they found that the knockout mouse embryos died midterm due to an inability to make mature red blood cells. At the least, the results suggest that ADAR1 and RNA editing are critical to the development of mature red blood cells, an essential step in mammalian embryo development. The new findings were published in the December 1 issue of Science.

"The inability of mice with a defective RNA editing system to make mature red blood cells is likely just the tip of the iceberg," says Wistar professor Kazuko Nishikura, Ph.D., senior author on the study. "The ADAR1 gene is expressed in many tissues throughout the body in addition to the brain and is probably involved in the RNA editing of a number of target genes that have not yet been identified."

As scientists prepare to enter the post-genomic era, the role of RNA editing in determining protein structure and function may become an increasingly important consideration in genetic research. Investigations such as Nishikuras indicate that RNA editing is fundamental

Contact: Marion Wyce
The Wistar Institute

Page: 1 2 3

Related biology news :

1. Chromosomal Abnormalities Key For Prediting Leukemia Outcome
2. Washington University in St. Louis leads group studying aging process
3. Byproduct of water-disinfection process found to be highly toxic
4. Patented process preserves transplant tissues/organs
5. New OHSU lab will speed drug discovery process
6. Oldest evidence for processing of wild cereals: starch grains from barley, wheat, on grinding stone
7. Study reveals surprising remodeling property of gene regulation process
8. FSU scientists develop new tests to detect nut allergens in processed food
9. Microscopy scans show how brain cells process energy
10. Frogs muscle-in on wasting process
11. New study confirms process leading to disorder causing male characteristics in women

Post Your Comments:

(Date:7/22/2020)... ... July 21, 2020 , ... USDM Life ... and compliance, announces a new solution to manage regulated workloads on Microsoft Azure. ... their technology stack complies with FDA and global regulations. USDM's new managed service ...
(Date:7/18/2020)... ... 17, 2020 , ... Commercial launch readiness is a critical stage in a ... cure or vaccine, the global economic downturn will only increase price pressures overall for ... and capturing full value from every product launch is critical. However, history shows that ...
(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient MasterClass webinars, ... revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of savory foods ... AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting & Food ...
Breaking Biology News(10 mins):
(Date:8/7/2020)... WOODLANDS, Texas (PRWEB) , ... August 06, 2020 ... ... therapy and DNA vaccine industries, announces it has closed on the purchase of ... Technology Park in Conroe, TX and includes over 21 acres in the initial ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, ... its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at ... requiring fast track capacity to provide patients with urgently needed vaccines and other ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as the solution ... history of eSource, the reasons it did not take off as quickly as people ... the industry is moving towards capturing data electronically for clinical trials and then repurposing ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery ... of a great surgery is only the beginning of a successful study, while protecting ... , Join Brad Gien, Global Head of Surgery from Envigo in a ...
Breaking Biology Technology:
Cached News: