HOME >> BIOLOGY >> NEWS
RNAi delivery system crosses blood-brain barrier to target brain cancer

Researchers have combined novel molecular targeting technologies to deliver gene-silencing therapy specifically to tumor cells shielded by a normally impermeable obstacle, the blood brain barrier.

In the June 1 issue of the journal Clinical Cancer Research, William Pardridge, M.D., UCLA, reported that a delivery packet equipped with two specific antibodies first recognizes the transferrin receptor, a key protein portal in the blood brain barrier, and then gains entry into brain cancer cells with the second antibody targeting the human insulin receptor.

Using the antibody keys to traverse both the blood brain barrier and the tumor cell membrane, the delivery packets--called liposomes--deposit a genetically engineered non-viral plasmid in the brain cancer cells. The plasmid encodes a short hairpin RNA (shRNA) designed to interfere with the expression of the epidermal growth factor receptor, EGFR, a potent proponent of tumor cell proliferation. The use of shRNA to silence gene expression is RNA interference (RNAi) technology.

When treated with a weekly intravenous dose of Dr. Pardridge's targeted therapeutic, mice with brain tumors survive almost twice as long compared to mice that do not receive the treatment.

"This is the first drug delivery system that demonstrates that by using RNA interference technology, you can prolong life threatened by cancer," said Dr. Pardridge, Professor of Medicine at UCLA. "By solving the delivery problem, powerful molecular tools and therapies such as RNA interference can be moved to clinical trials where they can be tested to see how much benefit the patient gets."

The delivery system designed by the Pardridge research team is much like a minute parcel with a primary delivery address, a forwarding delivery address, and a message that halts proliferation of the tumor cells.

Liposomes are the parcel. Composed of lipid, or fat, molecules that align to form an enclosed membrane much like a
'"/>

Contact: Russell Vanderboom
vanderboom@aacr.org
215-440-9300
American Association for Cancer Research
1-Jun-2004


Page: 1 2 3

Related biology news :

1. The birth of reproductive health: A difficult delivery
2. Radiologists provide safe delivery method for gene therapy
3. Study suggests insect-derived antimicrobial peptides could be used as drug-delivery vehicles
4. Nanoparticle probes are destined for major new role in medical diagnostics and drug delivery
5. Steroid-coated DNA represents new approach to gene delivery
6. Smart bomb delivery destroys tumors in mice
7. Drug delivery leaps biotech hurdles
8. Beyond patches and pills: the remarkable future of drug delivery
9. Microscience to license vaccine delivery technology
10. Hope for nano-scale delivery of medicine using a light beam to move liquid through tiny tubes
11. Brain damage in infants not always tied to delivery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/4/2017)... , Oct. 4, 2017  GCE Solutions, a global clinical ... data and document anonymization solution on October 4, 2017. Shadow is ... field to comply with policy 0070 of the European Medicines Agency ... data. ... GCE Solutions ...
(Date:8/15/2017)... , Aug. 15 2017   ivWatch LLC , a medical ... (IV) therapy, today announced receipt of its ISO 13485 Certification, the ... the International Organization for Standardization (ISO┬«). ... ivWatch Model 400 Continuous Monitoring device for the early detection ... "This is an important ...
(Date:6/30/2017)... ARLINGTON, Va. , June 30, 2017 /PRNewswire-USNewswire/ ... a leading developer and supplier of face and ... the ATA Featured Product provider program. ... created an innovative way to monitor a driver,s ... benefit greatly from being able to detect fatigue ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building ... corporate rebranding initiative announced today. The bold new look is part of a ... company moves into a significant growth period. , It will also expand its service ...
(Date:10/10/2017)... DALLAS , Oct. 10, 2017 International research firm ... IoT Strategy, will speak at the TMA 2017 Annual Meeting , ... key trends in the residential home security market and how smart safety ... ... "The ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
Cached News: