HOME >> BIOLOGY >> NEWS
RNAi delivery system crosses blood-brain barrier to target brain cancer

Researchers have combined novel molecular targeting technologies to deliver gene-silencing therapy specifically to tumor cells shielded by a normally impermeable obstacle, the blood brain barrier.

In the June 1 issue of the journal Clinical Cancer Research, William Pardridge, M.D., UCLA, reported that a delivery packet equipped with two specific antibodies first recognizes the transferrin receptor, a key protein portal in the blood brain barrier, and then gains entry into brain cancer cells with the second antibody targeting the human insulin receptor.

Using the antibody keys to traverse both the blood brain barrier and the tumor cell membrane, the delivery packets--called liposomes--deposit a genetically engineered non-viral plasmid in the brain cancer cells. The plasmid encodes a short hairpin RNA (shRNA) designed to interfere with the expression of the epidermal growth factor receptor, EGFR, a potent proponent of tumor cell proliferation. The use of shRNA to silence gene expression is RNA interference (RNAi) technology.

When treated with a weekly intravenous dose of Dr. Pardridge's targeted therapeutic, mice with brain tumors survive almost twice as long compared to mice that do not receive the treatment.

"This is the first drug delivery system that demonstrates that by using RNA interference technology, you can prolong life threatened by cancer," said Dr. Pardridge, Professor of Medicine at UCLA. "By solving the delivery problem, powerful molecular tools and therapies such as RNA interference can be moved to clinical trials where they can be tested to see how much benefit the patient gets."

The delivery system designed by the Pardridge research team is much like a minute parcel with a primary delivery address, a forwarding delivery address, and a message that halts proliferation of the tumor cells.

Liposomes are the parcel. Composed of lipid, or fat, molecules that align to form an enclosed membrane much like a
'"/>

Contact: Russell Vanderboom
vanderboom@aacr.org
215-440-9300
American Association for Cancer Research
1-Jun-2004


Page: 1 2 3

Related biology news :

1. The birth of reproductive health: A difficult delivery
2. Radiologists provide safe delivery method for gene therapy
3. Study suggests insect-derived antimicrobial peptides could be used as drug-delivery vehicles
4. Nanoparticle probes are destined for major new role in medical diagnostics and drug delivery
5. Steroid-coated DNA represents new approach to gene delivery
6. Smart bomb delivery destroys tumors in mice
7. Drug delivery leaps biotech hurdles
8. Beyond patches and pills: the remarkable future of drug delivery
9. Microscience to license vaccine delivery technology
10. Hope for nano-scale delivery of medicine using a light beam to move liquid through tiny tubes
11. Brain damage in infants not always tied to delivery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2019)... ... ... Dr. David Greene , Founder and CEO of R3 Stem Cell, ... the Rescue, was produced by Award Winning filmmaker Dr. Elliott Haimoff. , In the ... safety of the procedures along with the potential for helping patients avoid potentially risky ...
(Date:5/21/2019)... , ... May 21, 2019 , ... At their May ... for Tissue Engineered Medical Products (TEMPs) of the American Society for Testing and ... . Gaining this approval was the next step in the company’s plan to ...
(Date:5/15/2019)... ... 15, 2019 , ... The conventional method for characterizing brain ... ultra-thin two-dimensional slices, placed on glass microscope slides and qualitatively evaluated after staining. ... the brain is a highly heterogenous and complex tissue that is challenging to ...
Breaking Biology News(10 mins):
(Date:4/18/2019)... ... 2019 , ... Taking a step closer to a “green” ... Worcester Polytechnic Institute (WPI) has developed a novel process using an unusual solvent ... other biofuels more economically. , Isobutanol, like ethanol, is an alcohol, but its ...
(Date:4/10/2019)... ... April 10, 2019 , ... ... have locked into multiple agreements to help companies advance their innovations to ... industry, ranging from synthetic biology companies that are gene editing therapeutic cells ...
(Date:4/8/2019)... JORDAN, Utah and BOSTON (PRWEB) , ... April ... ... in delivering cloud-based enterprise-class unified communications and collaboration solutions, announced today the launch ... provides integration to an unprecedented range of business and contact-orientated applications while using ...
(Date:3/29/2019)... ... March 28, 2019 , ... ... milestones, CARB-X has proceeded with a second stage of funding for Specific’s Reveal™ ... which is on top of the $1.7 million already awarded by CARB-X. The ...
Breaking Biology Technology:
Cached News: