HOME >> BIOLOGY >> NEWS
RSRF-funded study leads to breakthrough for Rett Syndrome research

A collaborative study between the laboratories of Michael Greenberg of Children's Hospital Boston and Rudolf Jaenisch of the Whitehead Institute of Biomedical Research has resulted in a significant breakthrough. The investigators report in the October 31, 2003 issue of the prestigious journal Science, that the "Rett Syndrome gene", MECP2, regulates expression of the gene encoding brain-derived-neurotrophic factor (BDNF). The study was funded, in part, by the Rett Syndrome Research Foundation (RSRF). A paper by Yi Sun and colleagues of UCLA published in the same issue further corroborates Greenberg's and Janenisch's findings.

Rett Syndrome is a devastating neurological disorder diagnosed almost exclusively in girls. Children with Rett Syndrome (RTT) appear to develop normally until 6 to 18 months of age, when they enter a period of regression, losing speech and motor skills. Most develop repetitive hand movements, irregular breathing patterns, seizures and extreme motor control problems. RTT leaves its victims profoundly disabled, requiring maximum assistance with every aspect of daily living. There is no cure.

Although the protein implicated in RTT, MeCP2, is known, its precise function is not. Past experiments have demonstrated that MeCP2, acting like a biological deadbolt, binds to genes that have undergone methylation (a fundamental biological process in which the cell disables genes it doesn't use by modifying them with a methyl group) preventing them from activating. As a result, scientists theorized that MeCP2 was a "long-range gene repressor."

Jaenisch's lab, with RSRF funding, demonstrated that when MeCP2 is disabled in mice, the animals manifest Rett-like symptoms. The next step was to figure out why this happens and what genes MeCP2 targets.

Concurrently, Greenberg, who is also a professor of neurobiology at Harvard Medical School, was studying a central nervous system gene, BDNF, which is highly active in infants aged 6 t
'"/>

Contact: Monica Coenraads
monica@rsrf.org
203-445-9233
Rett Syndrome Research Foundation
30-Oct-2003


Page: 1 2 3

Related biology news :

1. Student science contest participation influences study, career choices, alumni say
2. New study shows hope for treating inhalant abuse
3. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
4. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
5. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
6. Phase II trials of second-generation antisense cancer drug planned following successful early study
7. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
8. Indiana University, EPA to study airborne PCBs
9. K-State, other universities to study how climate affects plant evolution
10. USC study links historical increases in life span to lower childhood exposure to infection
11. Washington University in St. Louis leads group studying aging process

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/6/2019)... ... 06, 2019 , ... NDA Partners Chairman Carl Peck, ... with expertise in clinical pharmacology and pharmacometrics and a widely recognized expert in ... joined the firm as an Expert Consultant. , Dr. Stanski has served in ...
(Date:11/5/2019)... ... November 05, 2019 , ... ... solutions for drugs, biologics, gene therapies, and consumer health products, today announced it ... Hotel Sofia, Barcelona, Spain on Nov. 12 – 14, 2019. , On Wednesday, ...
(Date:11/2/2019)... , ... November 01, 2019 , ... Stay on top ... and medical device industries. Access to all webinars is free, so be sure to ... your field! , Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL ...
Breaking Biology News(10 mins):
(Date:11/27/2019)... ... 2019 , ... Silony Medical, a medical technology company producing ... in the UK. The procedure was performed in the UK’s largest trauma center, ... Dr. Alexander Montgomery. The surgery, which took place on July 22, 2019, was ...
(Date:11/19/2019)... ... 19, 2019 , ... Supercomputing Conference – Cirrascale Cloud ... Autonomous Vehicle , Medical Imaging, and Natural Language Processing (NLP) workflows, today ... Poplar® software stack as part of its bare-metal cloud service offerings. In addition ...
(Date:11/12/2019)... ... November 12, 2019 , ... ... new Director of Forensic Genealogy, Melinde Lutz Byrne, to the organization. Byrne’s team ... ultimately provide investigative leads to law enforcement through proven genealogy and DNA analysis ...
(Date:11/6/2019)... ... November 06, 2019 , ... LeadingBiotech ,?an exclusive event ... its East/West CEO conference to be held January 11-12, 2020 at ... off the week of the J.P. Morgan Healthcare Conference and other biotech industry ...
Breaking Biology Technology:
Cached News: