HOME >> BIOLOGY >> NEWS
Radiation alone after surgery still the standard for head and neck cancer

A preliminary study has found no advantage to adding chemotherapy to radiation after surgery for treating advanced head and neck cancer patients. The findings of the research, to be presented at the American Society of Clinical Oncology meeting May 18, appear to set aside earlier data suggesting that a combination of chemotherapy and radiation would improve the odds of staying cancer-free after surgery. Results are published in abstract # 903 in the ASCO Program/Proceedings.

Recurrence and spread of head and neck cancer is common and fewer than half of these patients are expected to survive past five years. "Early studies suggested that combining certain chemotherapy drugs and radiation may have a synergistic effect in these patients," says Arlene Forastiere, M.D., professor of oncology and otolaryngology at the Johns Hopkins Kimmel Cancer Center and medical oncology co-chair of the study. "Our current study shows that adding the chemotherapy drug cisplatin to standard radiation treatment does not significantly reduce recurrence."

The study evaluated 407 patients who had surgery to remove their cancer and were at high risk for recurrence. After surgery, patients in one group received radiation alone and, in a second group, a combination of cisplatin and radiation.

In a preliminary analysis after two years, researchers found no significant difference between the two groups in the percentage of patients remaining cancer-free. The cancer recurred in 26 percent of patients receiving radiation alone and in 20 percent of those receiving chemotherapy and radiation. There also was no significant difference between the two groups in overall survival 63 percent in the combination therapy group versus 57 percent who received radiation only.

Just over half (58 percent) of the patients getting combination therapy were able to take all three doses of chemotherapy. The others did not tolerate the full dose. These patients experienced more s
'"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
18-May-2002


Page: 1 2

Related biology news :

1. Dazzling new light source opens at Stanford Synchrotron Radiation Laboratory
2. Radiation therapy targets cancer cells on two fronts, Science study says
3. Radiation-resistant organism reveals its defense strategies
4. Stanford Synchrotron Radiation Lab receives $6 million grant to decipher protein structures
5. No More Running Blind In A Maze-The Laboratory Rat Genetic And Radiation Hybrid Map Is Here
6. Mixing Radiation, Minerals, Toxic Waste Could Be Cleanup Boon -- Or Kaboom
7. UV Radiation Induces Vitamin A Deficiency In Skin
8. Combining Angiostatin With Radiation Enhances Anti-Cancer Effects Of Each
9. Amphibian Mortality Due To UV Radiation
10. Study Shows Hereditary Legacy Of Radiation Exposure
11. Geologist Finds Hidden Patterns Of Diversification In Ordovician Radiation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/15/2018)... ... September 14, 2018 , ... The first ever production picosecond-domain laser with a ... and purple tattoo inks - often the colors most resistant to laser removal. , ... of the American Society for Laser Medicine and Surgery, Inc. (ASLMS) investigated the safety ...
(Date:9/12/2018)... ... September 11, 2018 , ... Tennant ... introduce the new ChemXP™ line of high performance secondary containment coatings, designed to ... to provide Tennant Coatings’ elite certified installers with the needed solutions to protect ...
(Date:9/7/2018)... ... 05, 2018 , ... Following up on the launch of ... IPS-Integrated Project Services, LLC and G-CON Manufacturing have successfully designed and delivered the ... provides a pre-fabricated modular cleanroom infrastructure for the drug manufacturers’ requirements for both ...
Breaking Biology News(10 mins):
(Date:9/7/2018)... ... 06, 2018 , ... Cognition® Corporation , a software ... its upcoming user conference. , This year NAVIGATE2018 —the annual conference—will ... approaches to regulatory compliance and quality management. , “We’ve got a stellar lineup ...
(Date:9/1/2018)... ... August 31, 2018 , ... Rudina Thanasi, a scientifically validated ... biofield energy treated nutraceutical supplement used in combating inflammation and autoimmune disorders. ... as well as, organ-specific inflammation. The reported data is as follows: , ...
(Date:8/29/2018)... ... August 28, 2018 , ... ... announced today the successful completion of a $5.5 million funding round managed by ... Investment Fund, Commenda Capital, and Ellipsis Ventures. , “Our investment in Nanovis is ...
(Date:8/29/2018)... ... August 28, 2018 , ... CEO and founder of VetStem ... performed on an allogeneic (donor derived) stem cell product for osteoarthritis in canines ... in September. He is also the organizer of Breakout Session 4: Practitioner Primer ...
Breaking Biology Technology:
Cached News: