HOME >> BIOLOGY >> NEWS
Radiologists provide safe delivery method for gene therapy

OAK BROOK, Ill. Computed tomography (CT)-guided injections offer a safe delivery method for gene therapy in patients with metastatic kidney cancer, according to a study in the May issue of the journal Radiology.

Gene therapy involves introducing genetic material directly into cells to fight disease. "The new gene therapies offer promise for controlling certain types of cancer, but delivering the agents directly into tumors poses its own set of challenges," said the study's lead author, Robert D. Suh, M.D., who is an assistant clinical professor of radiology and director of thoracic interventional services at the David Geffen School of Medicine at University of California, Los Angeles (UCLA). "As research in gene therapy, or immunotherapy, progresses, we need a good gene therapy delivery mechanism."

Treatment of metastatic kidney cancer is difficult because the disease is largely resistant to chemotherapy. The only Food and Drug Administration (FDA)-approved immunotherapeutic treatment, recombinant interleukin-2 (IL-2), has a response rate of only 15 percent when administered intravenously, and its use is limited by significant and occasionally life-threatening side effects. Researchers have developed several gene therapy agents to improve the effectiveness and minimize the side effects of IL-2. UCLA's technique involves injecting an IL-2-encoded recombinant gene directly into cancer cells.

The researchers assessed the feasibility of using CT guidance to safely position a needle in both superficial and deep tumor sites to deliver gene therapy (IL-2 plasmid DNA).

"The CT images enabled us to precisely target the tumor, eliminating any guesswork about where to angle the needle and how deeply to inject the therapy," said Dr. Suh.

Twenty-nine patients with kidney cancer that had spread to the chest or abdomen received up to three cycles of six weekly injections directly into their tumors. A total of 284 CT-guided injections
'"/>

Contact: Maureen Morley
mmorley@rsna.org
630-590-7754
Radiological Society of North America
3-May-2004


Page: 1 2

Related biology news :

1. Picking prostanoids to provide protection
2. Study by Israeli scientists provides insight on DNA code
3. Adaptive changes in the genome may provide insight into the genetics of complex disease
4. Essential smell gene may provide key to new insect repellents
5. Clemson University spin-off uses corn to make plastics, provide cleaner air
6. Method to visualize gene activity may provide insight into normal development & genome function
7. Study by Tufts biologist provides window into progression of some degenerative diseases
8. New discovery could provide tool to detect whether a cancer will develop and spread
9. Protective mechanism exploited by tumors may provide new cancer treatment
10. Rolling Store provides model for overcoming barriers to healthy foods and better health outcomes
11. Fat cells could provide the key to a longer life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/13/2018)... ... ... Illumina, Kaiser Permanente, ResMed and Aetna were just a few of the ... events company has hosted an impressive guest list of Fortune 500 businesses, namely due ... who visits receives a completely customized experience, right down to the menu and the ...
(Date:12/13/2018)... , ... December 13, 2018 , ... ... released a must-see documentary entitled “What Researchers Need to Know about Antibody ... in Life Science Research series. The goal of this film is to educate ...
(Date:12/10/2018)... ... December 10, 2018 , ... Today, RoosterBio ... their shared goal of accelerating the development of the Regenerative Medicine field. ... TRT’s core technology around human umbilical cord perivascular cells (HUCPVCs). Together, it ...
Breaking Biology News(10 mins):
(Date:12/13/2018)... ... December 12, 2018 , ... Helping conclude Healthy Aging Month this past September, ... aid within its Vision and Hearing campaign that sets out to shed light on ... despite continued efforts to destigmatize hearing aids over the years, 9 out of 10 ...
(Date:12/10/2018)... SAN DIEGO (PRWEB) , ... ... ... Ltd., a fully integrated Contract Development and Manufacturing Organization (CDMO) with sites ... characterization, conjugation optimization, cGMP manufacturing, and aseptic fill finish solutions for monoclonal ...
(Date:12/5/2018)... (PRWEB) , ... December 05, 2018 , ... The incredible ... paid tribute to in the European Parliament by Carlos Moedas, the European Commissioner for ... EU Research and Innovation in Our Daily Lives, Commissioner Moedas spoke at length of ...
(Date:12/5/2018)... CHARLOTTESVILLE, Va. and LONDON (PRWEB) , ... ... ... Atlantic Research Group (ARG), an established North American full-service contract research organization ... CRO. Effective immediately, the transaction significantly strengthens ARG’s reach and experience in ...
Breaking Biology Technology:
Cached News: