HOME >> BIOLOGY >> NEWS
Radiologists provide safe delivery method for gene therapy

OAK BROOK, Ill. Computed tomography (CT)-guided injections offer a safe delivery method for gene therapy in patients with metastatic kidney cancer, according to a study in the May issue of the journal Radiology.

Gene therapy involves introducing genetic material directly into cells to fight disease. "The new gene therapies offer promise for controlling certain types of cancer, but delivering the agents directly into tumors poses its own set of challenges," said the study's lead author, Robert D. Suh, M.D., who is an assistant clinical professor of radiology and director of thoracic interventional services at the David Geffen School of Medicine at University of California, Los Angeles (UCLA). "As research in gene therapy, or immunotherapy, progresses, we need a good gene therapy delivery mechanism."

Treatment of metastatic kidney cancer is difficult because the disease is largely resistant to chemotherapy. The only Food and Drug Administration (FDA)-approved immunotherapeutic treatment, recombinant interleukin-2 (IL-2), has a response rate of only 15 percent when administered intravenously, and its use is limited by significant and occasionally life-threatening side effects. Researchers have developed several gene therapy agents to improve the effectiveness and minimize the side effects of IL-2. UCLA's technique involves injecting an IL-2-encoded recombinant gene directly into cancer cells.

The researchers assessed the feasibility of using CT guidance to safely position a needle in both superficial and deep tumor sites to deliver gene therapy (IL-2 plasmid DNA).

"The CT images enabled us to precisely target the tumor, eliminating any guesswork about where to angle the needle and how deeply to inject the therapy," said Dr. Suh.

Twenty-nine patients with kidney cancer that had spread to the chest or abdomen received up to three cycles of six weekly injections directly into their tumors. A total of 284 CT-guided injections
'"/>

Contact: Maureen Morley
mmorley@rsna.org
630-590-7754
Radiological Society of North America
3-May-2004


Page: 1 2

Related biology news :

1. Picking prostanoids to provide protection
2. Study by Israeli scientists provides insight on DNA code
3. Adaptive changes in the genome may provide insight into the genetics of complex disease
4. Essential smell gene may provide key to new insect repellents
5. Clemson University spin-off uses corn to make plastics, provide cleaner air
6. Method to visualize gene activity may provide insight into normal development & genome function
7. Study by Tufts biologist provides window into progression of some degenerative diseases
8. New discovery could provide tool to detect whether a cancer will develop and spread
9. Protective mechanism exploited by tumors may provide new cancer treatment
10. Rolling Store provides model for overcoming barriers to healthy foods and better health outcomes
11. Fat cells could provide the key to a longer life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... 2019 , ... Join Jonathan Riek, PhD, VP, Musculoskeletal & Metabolic Imaging, ... at 1pm EDT to learn about two common imaging methods in NAFLD/NASH to aid ... most common diffuse liver disease, with a worldwide prevalence of 20-46 percent. NAFLD can ...
(Date:8/9/2019)... (PRWEB) , ... August 09, 2019 , ... With a ... patients, more and more patients will visit urgent care centers (UCC) in the coming ... Information. The report, The Market for Urgent Care Centers , is a detailed ...
(Date:8/6/2019)... Wis. (PRWEB) , ... August 06, 2019 , ... ... health, sustainability, and environmental concerns. One plant-based food in particular quickly entered the ... animal-meat counterparts, product developers use a thermogelling and emulsifying ingredient such as methyl ...
Breaking Biology News(10 mins):
(Date:8/6/2019)... (PRWEB) , ... August 06, 2019 , ... ... Radio (LSMR) have joined forces in launching the biweekly SDBN BUZZ podcast focused ... growth. SDBN BUZZ podcast will also serve to promote the region and attract ...
(Date:8/4/2019)... ... 2019 , ... Cirtec Medical Corporation, a strategic outsourcing partner for complex medical ... construction on a 30,000 sq. ft. manufacturing facility in the Coyol free zone, ... facility, which is expected to be fully operational by the end of the year, ...
(Date:7/19/2019)... ... 2019 , ... Global precision motion and piezo technology solutions ... facilities in Lederhose, Germany, increasing their current footprint by half again. , The ... addition to general office space, a significant increase to its existing 129,000ft² structure. ...
(Date:7/17/2019)... ... 2019 , ... Quidel is the market leader in point-of-care ... and Siemens Healthineers and Response Biomedical also are among the top companies. The ... (POC) Diagnostics . , Quidel is a market leader in rapid immunoassays and ...
Breaking Biology Technology:
Cached News: