Using brain imaging, neuroscientists at the NIH's National Institute of Mental Health (NIMH) have pinpointed the site of a defect in a brain circuit associated with a specific thinking deficit. Their study demonstrates how a rare genetic disorder, Williams Syndrome, can offer clues as to how genetic flaws may translate into cognitive symptoms in more common and complex major mental disorders. Andreas Meyer-Lindenberg, M.D., Karen Berman, M.D., and colleagues, traced the thinking deficit to a circuit at the back of the brain that processes locations of objects in the visual field. The researchers report on their Magnetic Resonance Imaging (MRI) study in the September 2, 2004 Neuron.
The study focused on the inability to visualize an object as a set of parts and then construct a replica, as in assembling a puzzle a key cognitive deficit experienced by people with Williams Syndrome. In addition to this visuospatial construction deficit, people with Williams Syndrome also tend to be overly friendly and anxious and often have mental retardation and learning disabilities. Compared to most mental disorders, which are thought to involve complex interactions between multiple genes and environmental triggers, the genetic basis of Williams Syndrome is remarkably well understood. People with the disorder lack about 21 genes in a particular part of chromosome 7.
"Williams Syndrome yields a unique opportunity to study how genes influence our ability to construct our social and spatial worlds," said NIMH Director Thomas Insel, M.D. "By studying people with this disorder, we can discover how genetic mutations change not only molecular and cellular processes, but lead to differences in the brain circuitry for complex aspects of cognition."
To identify where in the brain things go awry in the visuospatial construction deficit, Meyer-Lindenberg and Berman recruited 13 "high functioning" Williams Syndrome patients with normal intelligence. Even though they wPage: 1 2 3 Related biology news :1
Contact: Jules Asher
NIH/National Institute of Mental Health
. Decreasing toxins in brains of Alzheimers patients keep cognitive deficits at bay2
. Researchers target deficit irrigation for wine grapes3
. Lack of specific brain protein causes marked deficits in learning, memory4
. Gray matter damage in the brain of MS patients linked to cognitive, physical deficits5
. Adult alcoholism and attention-deficit hyperactivity disorder are connected6
. Rutgers researcher advances understanding of attention deficit disorder and schizophrenia7
. Is there a link between soy formula and attention deficit disorder?8
. ADHD in a SNAP: The SNAP gene in attention deficit hyperactivity9
. The immune system may be involved in the susceptibility to childhood attention deficit hyperactivity disorder (ADHD)10
. Glucose deficit affects young and old, could impact school schedules11
. A stomach enzyme deficit may place women at more risk from drinking alcohol