HOME >> BIOLOGY >> NEWS
Rats depleted of salt become sensitized to amphetamine, show unusual growth of brain cells

Laboratory rats that have been repeatedly depleted of salt become sensitized to amphetamine, exhibiting an exaggerated hyperactive response to the drug and an unusual pattern of neuronal growth in a part of their brains, neuroscientists have found.

The researchers, headed by University of Washington psychologist Ilene Bernstein, discovered that nerve cells in the nucleus accumbens of sensitized rats have more branches and were 30 percent to 35 percent longer than normal. The nucleus accumbens, located in the forebrain, is involved in the reward and motivation system in rats and in humans. It is associated with regulating motivated behaviors of such natural drives as those for food and salt, and for artificial rewards provided by drugs.

The findings are published in the current issue of the Journal of Neuroscience.

"This number, 30 to 35 percent, is startling and implies an ability for neurons to make more connections," said Bernstein.

The research was triggered by several recent papers. One reported that rats sensitized to amphetamine showed this type of neuron growth. A second found that rats deprived of food seemed to be amphetamine sensitized. When an animal or person becomes sensitized their behavior changes. With amphetamine, animals and people become hyperactive. Rats that are salt sensitized drink and eat salt more rapidly and in greater quantities. Why they behave this way is unknown, Bernstein said.

"That research and ours seem to indicate that being hungry or sodium deprived enough can change an animal's or a person's response to a drug even if they have not been exposed to the drug previously," she said.

"We don't know if this holds up in humans. But the same part of the brain and the response to drugs holds up across species. The same systems are involved in rats and humans when it comes to amphetamines and cocaine. This suggests evidence of a common natural substrate to natural and artifici
'"/>

Contact: Joel Schwarz
joels@u.washington.edu
206-543-2580
University of Washington
3-Jun-2002


Page: 1 2 3

Related biology news :

1. $18 million bioinformatics center to become weapon against deadly diseases
2. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
3. Brain cells become more discriminating when they work together
4. How meals become bones
5. Adult mouse bone marrow stem cells can become cells of the nervous system
6. Weizmann Institute scienists find that stem cells in the bone marrow become liver cells
7. Another global warming surprise: Grasslands may become wetter as temperatures rise
8. Indiana University to become NASA base for space biology studies
9. UNC HIV-AIDS screening, prevention method could become national model for cutting illness
10. Clock tells time at such speed that reading it becomes challenge
11. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory

Post Your Comments:
(Date:7/27/2015)... ANGELES , July 27, 2015   ... evidence- and experience-based clinical improvement solutions, today announced ... solution is now available on Android smartphones and ... inpatient and post-care organizations can use ZynxCarebook to ... same patient,s condition, streamline care transitions to other ...
(Date:7/21/2015)... , July 21, 2015  NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... wallet, announces that it has filed provisional patent ... Method. This invention highlights next ... authorizes an account, but also the user using ...
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/188684 for BEHAVIORAL-DIRECTED ... another new convenient and secure method to make ... innovative payment methods, introduced with its groundbreaking voice-direct ...
Breaking Biology News(10 mins):Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4
(Date:7/29/2015)... BANGALORE , July 30, 2015 ... Cell Market - Growth, Trends & Forecasts (2015-2020), , published ... worth US$ 30.25 billion by the end of 2020, with ... globally accounting for more than 40% of the global market ... grow at a CAGR of 13.7% during the period of ...
(Date:7/29/2015)... Ala., July 29, 2015  HealthSouth ... nation,s largest providers of post-acute healthcare services, offering ... its results of operations for the second quarter ... quarter was characterized by strong volume growth in ... Adjusted EBITDA," said Jay Grinney, President and Chief ...
(Date:7/29/2015)... ... 29, 2015 , ... Brady (NYSE:BRC), a global leader in ... To align chemical container labeling with OSHA’s updated Hazard Communication (HazCom) Standard and ... example of an accurate label, and pictogram uses and meanings. , “With changes ...
(Date:7/29/2015)...  Indivior PLC (LON: INDV) today announced that the ... accepted and received Priority Review by the U.S. Food ... overdose. This naloxone nasal spray comes as a pre-filled ... into the nasal mucosa. 1 The device has ... be better equipped to help an opioid overdose victim. ...
Breaking Biology Technology:Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3HealthSouth Reports Results for Second Quarter 2015 2HealthSouth Reports Results for Second Quarter 2015 3HealthSouth Reports Results for Second Quarter 2015 4HealthSouth Reports Results for Second Quarter 2015 5HealthSouth Reports Results for Second Quarter 2015 6HealthSouth Reports Results for Second Quarter 2015 7HealthSouth Reports Results for Second Quarter 2015 8HealthSouth Reports Results for Second Quarter 2015 9HealthSouth Reports Results for Second Quarter 2015 10HealthSouth Reports Results for Second Quarter 2015 11HealthSouth Reports Results for Second Quarter 2015 12HealthSouth Reports Results for Second Quarter 2015 13HealthSouth Reports Results for Second Quarter 2015 14HealthSouth Reports Results for Second Quarter 2015 15HealthSouth Reports Results for Second Quarter 2015 16HealthSouth Reports Results for Second Quarter 2015 17HealthSouth Reports Results for Second Quarter 2015 18HealthSouth Reports Results for Second Quarter 2015 19HealthSouth Reports Results for Second Quarter 2015 20HealthSouth Reports Results for Second Quarter 2015 21HealthSouth Reports Results for Second Quarter 2015 22HealthSouth Reports Results for Second Quarter 2015 23HealthSouth Reports Results for Second Quarter 2015 24HealthSouth Reports Results for Second Quarter 2015 25HealthSouth Reports Results for Second Quarter 2015 26HealthSouth Reports Results for Second Quarter 2015 27HealthSouth Reports Results for Second Quarter 2015 28HealthSouth Reports Results for Second Quarter 2015 29HealthSouth Reports Results for Second Quarter 2015 30HealthSouth Reports Results for Second Quarter 2015 31HealthSouth Reports Results for Second Quarter 2015 32HealthSouth Reports Results for Second Quarter 2015 33HealthSouth Reports Results for Second Quarter 2015 34
Cached News: