HOME >> BIOLOGY >> NEWS
Rats depleted of salt become sensitized to amphetamine, show unusual growth of brain cells

Laboratory rats that have been repeatedly depleted of salt become sensitized to amphetamine, exhibiting an exaggerated hyperactive response to the drug and an unusual pattern of neuronal growth in a part of their brains, neuroscientists have found.

The researchers, headed by University of Washington psychologist Ilene Bernstein, discovered that nerve cells in the nucleus accumbens of sensitized rats have more branches and were 30 percent to 35 percent longer than normal. The nucleus accumbens, located in the forebrain, is involved in the reward and motivation system in rats and in humans. It is associated with regulating motivated behaviors of such natural drives as those for food and salt, and for artificial rewards provided by drugs.

The findings are published in the current issue of the Journal of Neuroscience.

"This number, 30 to 35 percent, is startling and implies an ability for neurons to make more connections," said Bernstein.

The research was triggered by several recent papers. One reported that rats sensitized to amphetamine showed this type of neuron growth. A second found that rats deprived of food seemed to be amphetamine sensitized. When an animal or person becomes sensitized their behavior changes. With amphetamine, animals and people become hyperactive. Rats that are salt sensitized drink and eat salt more rapidly and in greater quantities. Why they behave this way is unknown, Bernstein said.

"That research and ours seem to indicate that being hungry or sodium deprived enough can change an animal's or a person's response to a drug even if they have not been exposed to the drug previously," she said.

"We don't know if this holds up in humans. But the same part of the brain and the response to drugs holds up across species. The same systems are involved in rats and humans when it comes to amphetamines and cocaine. This suggests evidence of a common natural substrate to natural and artifici
'"/>

Contact: Joel Schwarz
joels@u.washington.edu
206-543-2580
University of Washington
3-Jun-2002


Page: 1 2 3

Related biology news :

1. $18 million bioinformatics center to become weapon against deadly diseases
2. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
3. Brain cells become more discriminating when they work together
4. How meals become bones
5. Adult mouse bone marrow stem cells can become cells of the nervous system
6. Weizmann Institute scienists find that stem cells in the bone marrow become liver cells
7. Another global warming surprise: Grasslands may become wetter as temperatures rise
8. Indiana University to become NASA base for space biology studies
9. UNC HIV-AIDS screening, prevention method could become national model for cutting illness
10. Clock tells time at such speed that reading it becomes challenge
11. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory

Post Your Comments:
(Date:7/2/2015)... -- Fingerprint Cards has received an order for ... the distributor World Peace Industrial Group (WPI), part of WPG ... Asia . Deliveries are planned to take place during ... smartphone manufacturers in Asia . The order ... guidance of approximately 2,200 MSEK for 2015. Jörgen ...
(Date:6/30/2015)... , June 30, 2015 Genisphere ... as CEO to help further develop Genisphere,s therapeutics capabilities ... partnering experience, having spent much of the last 25 ... Amgen, Baxter Bioscience, and Johnson & Johnson. Tom started ... Technology and Biotech Corporate Finance. He graduated from Dartmouth ...
(Date:6/26/2015)... 2015 ATL Technology, LLC, a top provider of ... single use solutions, headquartered in Springville, Utah ... California corporation with locations in ... Costa Rica ). This acquisition will incorporate ... with ATL Technology,s existing facility in Costa Rica ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2
(Date:7/6/2015)... , June 29, 2015 ... has announced the addition of the "Biotechnology ... Biotechnology for the Non-Biotechnologist, ideal for ... theory, principles, techniques and potential of biotechnology. ... understand the basic theory, principles, techniques, and potential ...
(Date:7/5/2015)... NY (PRWEB) , ... July 06, 2015 , ... For ... If a user had a high-end machine such as a Varian Cary 4000-7000, a ... So widespread was this design that even NIST used them for their SRM-2031 series ...
(Date:7/3/2015)... ... July 03, 2015 , ... The global failure analysis ... from 2015 to 2020. The bioscience market is expected to grow at the highest ... of failure analysis equipment in the research labs and academic institutions for root cause ...
(Date:7/3/2015)... 2015 Forskere kan ... på  http://www.openinnovationinscience.at om efteruddannelsesprogrammet "Lab for ... i Wien .  ... forskere og videnskabsmænd foretaget af Ludwig Boltzmann ... for sundhedsvidenskaben manglen på incitamenter til at ...
Breaking Biology Technology:FireflySci Simplifies the Calibration of UV Spectrophotometers with FUV Photometric Accuracy Standards 2FireflySci Simplifies the Calibration of UV Spectrophotometers with FUV Photometric Accuracy Standards 3Failure Analysis Market to Grow at 7.52% CAGR to 2020 2Failure Analysis Market to Grow at 7.52% CAGR to 2020 3Failure Analysis Market to Grow at 7.52% CAGR to 2020 4Failure Analysis Market to Grow at 7.52% CAGR to 2020 5Lancering af verdens første åbne innovationsprogram til uddannelse af forskere 2Lancering af verdens første åbne innovationsprogram til uddannelse af forskere 3
Cached News: