HOME >> BIOLOGY >> NEWS
Rats depleted of salt become sensitized to amphetamine, show unusual growth of brain cells

Laboratory rats that have been repeatedly depleted of salt become sensitized to amphetamine, exhibiting an exaggerated hyperactive response to the drug and an unusual pattern of neuronal growth in a part of their brains, neuroscientists have found.

The researchers, headed by University of Washington psychologist Ilene Bernstein, discovered that nerve cells in the nucleus accumbens of sensitized rats have more branches and were 30 percent to 35 percent longer than normal. The nucleus accumbens, located in the forebrain, is involved in the reward and motivation system in rats and in humans. It is associated with regulating motivated behaviors of such natural drives as those for food and salt, and for artificial rewards provided by drugs.

The findings are published in the current issue of the Journal of Neuroscience.

"This number, 30 to 35 percent, is startling and implies an ability for neurons to make more connections," said Bernstein.

The research was triggered by several recent papers. One reported that rats sensitized to amphetamine showed this type of neuron growth. A second found that rats deprived of food seemed to be amphetamine sensitized. When an animal or person becomes sensitized their behavior changes. With amphetamine, animals and people become hyperactive. Rats that are salt sensitized drink and eat salt more rapidly and in greater quantities. Why they behave this way is unknown, Bernstein said.

"That research and ours seem to indicate that being hungry or sodium deprived enough can change an animal's or a person's response to a drug even if they have not been exposed to the drug previously," she said.

"We don't know if this holds up in humans. But the same part of the brain and the response to drugs holds up across species. The same systems are involved in rats and humans when it comes to amphetamines and cocaine. This suggests evidence of a common natural substrate to natural and artifici
'"/>

Contact: Joel Schwarz
joels@u.washington.edu
206-543-2580
University of Washington
3-Jun-2002


Page: 1 2 3

Related biology news :

1. $18 million bioinformatics center to become weapon against deadly diseases
2. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
3. Brain cells become more discriminating when they work together
4. How meals become bones
5. Adult mouse bone marrow stem cells can become cells of the nervous system
6. Weizmann Institute scienists find that stem cells in the bone marrow become liver cells
7. Another global warming surprise: Grasslands may become wetter as temperatures rise
8. Indiana University to become NASA base for space biology studies
9. UNC HIV-AIDS screening, prevention method could become national model for cutting illness
10. Clock tells time at such speed that reading it becomes challenge
11. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... 2017 , ... RURO, Inc., a leading LIMS, RFID, and ... update to the Limfinity® framework. , LimitLIS® and other RURO solutions based on ... customers among labs and other businesses. Limfinity® 6.5 adds new features and improvements ...
(Date:6/20/2017)... ... June 20, 2017 , ... CTNext ... of directors has formed a Higher Education Entrepreneurship Advisory Committee to implement the ... presidents and other high-ranking representatives from 35 higher education institutions across the state ...
(Date:6/20/2017)... ... 20, 2017 , ... HorizonScan is providing food and ingredient ... likely threat to their products at the annual IFT conference in Las Vegas, ... expo attracts over 20,000 attendees representing food science professionals from over 90 countries ...
(Date:6/20/2017)... ... 2017 , ... National executive search firm, Slone Partners, announces ... and biomarker expertise, as VP of Scientific Affairs at Cambridge Biomedical. , ... development and sample testing services. The organization acts as a leading provider of ...
Breaking Biology Technology:
Cached News: