HOME >> BIOLOGY >> NEWS
Rats depleted of salt become sensitized to amphetamine, show unusual growth of brain cells

Laboratory rats that have been repeatedly depleted of salt become sensitized to amphetamine, exhibiting an exaggerated hyperactive response to the drug and an unusual pattern of neuronal growth in a part of their brains, neuroscientists have found.

The researchers, headed by University of Washington psychologist Ilene Bernstein, discovered that nerve cells in the nucleus accumbens of sensitized rats have more branches and were 30 percent to 35 percent longer than normal. The nucleus accumbens, located in the forebrain, is involved in the reward and motivation system in rats and in humans. It is associated with regulating motivated behaviors of such natural drives as those for food and salt, and for artificial rewards provided by drugs.

The findings are published in the current issue of the Journal of Neuroscience.

"This number, 30 to 35 percent, is startling and implies an ability for neurons to make more connections," said Bernstein.

The research was triggered by several recent papers. One reported that rats sensitized to amphetamine showed this type of neuron growth. A second found that rats deprived of food seemed to be amphetamine sensitized. When an animal or person becomes sensitized their behavior changes. With amphetamine, animals and people become hyperactive. Rats that are salt sensitized drink and eat salt more rapidly and in greater quantities. Why they behave this way is unknown, Bernstein said.

"That research and ours seem to indicate that being hungry or sodium deprived enough can change an animal's or a person's response to a drug even if they have not been exposed to the drug previously," she said.

"We don't know if this holds up in humans. But the same part of the brain and the response to drugs holds up across species. The same systems are involved in rats and humans when it comes to amphetamines and cocaine. This suggests evidence of a common natural substrate to natural and artifici
'"/>

Contact: Joel Schwarz
joels@u.washington.edu
206-543-2580
University of Washington
3-Jun-2002


Page: 1 2 3

Related biology news :

1. $18 million bioinformatics center to become weapon against deadly diseases
2. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
3. Brain cells become more discriminating when they work together
4. How meals become bones
5. Adult mouse bone marrow stem cells can become cells of the nervous system
6. Weizmann Institute scienists find that stem cells in the bone marrow become liver cells
7. Another global warming surprise: Grasslands may become wetter as temperatures rise
8. Indiana University to become NASA base for space biology studies
9. UNC HIV-AIDS screening, prevention method could become national model for cutting illness
10. Clock tells time at such speed that reading it becomes challenge
11. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory

Post Your Comments:
(Date:11/7/2014)... Auguste, associate professor, biomedical engineering, in the Grove ... New York, have identified a molecule that could ... most aggressive forms of breast cancer. , Triple ... rate owing to aggressive proliferation and metastasis and ... Auguste,s team, discovered the overexpression of intercellular adhesion ...
(Date:11/6/2014)... because of metastasis, yet progress in preventing and ... "It,s been particularly challenging to design drugs that ... in systems biology at Harvard Medical School. ... they,ve already metastasized." , Gujral and colleagues have ... researchers better understand how metastasis begins. Their findings ...
(Date:11/5/2014)... – Kelly Redmond has dedicated his career to ... to a general audience. , As deputy director ... Center at Nevada,s Desert Research Institute, Redmond has ... management, application and dissemination of climate data to ... Fall Meeting in San Francisco on December 15-19, ...
Breaking Biology News(10 mins):Migration negation 2Migration negation 3Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2
(Date:11/26/2014)... (PRWEB) November 25, 2014 Silicon Valley ... forces with RPM Alliance , provider of clinical ... companies. With the latest addition to its CRO Partnership ... validated EDC system to India. , “We have ... robust and customizable EDC platform which is both user ...
(Date:11/26/2014)... (PRWEB) November 25, 2014 The Pittcon ... its official conference and exposition mobile app, ... free download in the App Store for iOS and ... valuable resource tool before, during and after the event. ... details on exhibiting companies, technical sessions, Conferee Networking sessions ...
(Date:11/26/2014)... Miles Holder, formerly of Micron Research ... Products team as Sales/Marketing Manager. Mr. Holder has over ... for the graphite industry. , “We are thrilled to ... Dave Trinkley, VP of Market and Product Development for ... in the graphite industry, along with his proven track ...
(Date:11/26/2014)... WILMINGTON, DE (PRWEB) November 26, 2014 ... MPN Heroes recognition reception on December 5, 2014, in ... annual meeting. The MPN Heroes event will honor clinicians, ... the field of myeloproliferative neoplasms (MPNs). , Special ... will discuss his family's cancer journey at the reception. ...
Breaking Biology Technology:RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2Pittcon Releases 2015 Mobile App 2Miles Holder Joins Graphel Corporation as Sales/Marketing Manager 2CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4
Cached News: