NASHVILLE, Tenn. Raymond N. DuBois Jr., M.D., Ph.D., is the 26th recipient of the Richard and Hinda Rosenthal Foundation Award to recognize research that has made or promises to make a notable contribution to improved cancer care.
The award is presented annually by the American Association for Cancer Research (AACR). It will be awarded during the AACRs annual meeting in April.
The AACR is honoring DuBois for his seminal work in colorectal cancer research, including his contributions to understanding the role of the enzyme cyclooxygenase-2 (COX-2). His work has been the catalyst for the expanding field or research into COX-2 and the carcinogenic process, the AACR said in a statement. It has already had significant impact on patient care, with the recent approval of celecoxib, a COX-2 inhibitor, for the reduction of polyp formation in patients with familial adenomatous polyposis, an inherited disease in which hundreds of polyps form and, if left untreated, develop into tumors.
Clinical trials are under way to determine the usefulness of this drug in individuals who face a more typical risk of colorectal cancer. Additional work by DuBois and others suggests that COX-2 inhibitors may also play a role in treating lung and other forms of cancer; clinical trials are also beginning in this area.
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Contact: Cynthia Manley
Vanderbilt University Medical Center
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