HOME >> BIOLOGY >> NEWS
Rb protein's role in retina development is key to understanding devastating eye cancer

The finding that a tumor-suppressor protein called Rb is required for proper development of the mouse retina is a major step toward understanding why some children develop the devastating eye cancer called retinoblastoma. This discovery should eventually help scientists design a better treatment for this disease, according to investigators at St. Jude Children's Research Hospital. An article about this research is published in the Feb. 29 issue of Nature Genetics.

The St. Jude team showed that Rb limits the proliferation of immature retinal cells so the retina develops to a normal size. The Rb protein also prompts specific cells to develop into light-sensitive cells called rods.

The study results also offer clues to solving a long-standing paradox, according to Michael A. Dyer, Ph.D., an assistant member of the Department of Neurobiology and senior author of the Nature Genetics article.

"Children who lack the gene for Rb are at high risk for developing retinoblastoma, yet mice that also lack the Rb gene do not develop the disease," Dyer said. "The first step to solving that paradox and understanding why mice without the Rb protein don't get retinoblastoma is figuring out what that protein does during normal mouse development. Our study was that first step. What we're learning could eventually help us to block the molecular signals that trigger retinoblastoma in children."

Understanding the development of tissues and organs can also help researchers understand why certain types of pediatric tumors occur. The study provides strong evidence that retinoblastoma is a developmental tumor, caused by a genetic abnormality in a tissue or organ present in the developing embryo. Following birth, this abnormality triggers cancer in that tissue or organ during infancy or childhood.

The St. Jude study also broke new ground in the study of retinal development by overcoming a major obstacle blocking earlier researchers from studying the role
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
2-Mar-2004


Page: 1 2

Related biology news :

1. Optimizing proteins death domain halts leukemia in laboratory study
2. Findings suggest need for new view of p53 cancer proteins interaction with DNA
3. A proteins role in progressive renal disease
4. Researchers view proteins structural changes in real time
5. Misfolding the key to proteins ability to kill brain cells
6. Researchers solve killer proteins crime
7. Biologists discover proteins impace on plant-water balance
8. Penn researchers proteins link to leukemia
9. Imaging technique reveals new structure in retinal cells
10. Purdue researchers create templates on retinal tissues
11. Key gene in orchestrating embryo development also fine tunes organization of the retina

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/9/2019)... ... 09, 2019 , ... With a demand in healthcare to lower unneeded emergency ... urgent care centers (UCC) in the coming years, according to a new report on ... Urgent Care Centers , is a detailed look at the current state of these ...
(Date:8/6/2019)... ... August 06, 2019 , ... The demand for ... food in particular quickly entered the limelight – meat alternatives. Yet, to make ... and emulsifying ingredient such as methyl cellulose. This ingredient is highly synthetic. Having ...
(Date:8/1/2019)... ... July 30, 2019 , ... Keck Graduate Institute (KGI) ... Rathmann Professor in Bioprocessing and Director of the Amgen Bioprocessing Center, effective July ... industry and possesses more than 25 years of global experience in bioprocessing,” Schuster ...
Breaking Biology News(10 mins):
(Date:7/19/2019)... , ... July 18, 2019 , ... ... as “Ravi Everest,” will be joining forces with California-based charity Coalition Duchenne for ... July 20-22nd. Coalition Duchenne raises awareness and funding for Duchenne muscular dystrophy and ...
(Date:7/11/2019)... LAS VEGAS (PRWEB) , ... July 11, 2019 , ... ... 2019, R3 provided complimentary regenerative therapies to eight military Veterans under the R3 Heroes ... procedures being complimentary. , The R3 Heroes Program allow anyone to nominate a military ...
(Date:6/26/2019)... , ... June 26, 2019 , ... Alice Branton today ... on improving physicochemical properties of Magnesium Gluconate, which can prove to be beneficial for ... alteration of characteristic differentiation peak, change in crystallite size , Over 142% ...
(Date:6/11/2019)... (PRWEB) , ... June 10, 2019 , ... ... of its distribution network with the appointment of Biofeedback Tech Ltd ... monitoring systems are an essential part of many therapeutic treatments and clinical assessment ...
Breaking Biology Technology:
Cached News: