HOME >> BIOLOGY >> NEWS
Reading ability and ADHD affected by same genes

Attention deficit hyperactivity disorder (ADHD) and reading disability (RD) are common disorders of childhood that often co-occur. About 20-25% of children and adolescents with ADHD have a reading disability but the cause of this association is unknown. Twin and family studies suggest that genes, strongly indicated for both conditions, may underlie their association.

In a systematic genome-wide investigation of reading ability in a sample of 233 siblings diagnosed with ADHD, four chromosomal regions emerged as potential locations for genes underlying reading ability. Reading ability was measured by three types of reading tests including a spelling task, a reading recognition task, and a reading comprehension task. Because performance on all three measures was highly correlated, a reading factor representing performance on all three was used in the analysis, as well as the individual test scores. A dense set of highly informative molecular markers covering the human genome at about a 10cM density was used to investigate linkage. Linkage was determined based on increased sharing of molecular markers across the 233 sibling pairs against that expected for siblings due to their degree of genetic relationship.

Four regions found on chromosomes 2p, 10q, 16p, and 17q, showed suggestive evidence for linkage. Three of the locations (10q, 16p, 17q) overlapped regions suggested from previous investigations of ADHD and one region (2p) overlapped that suggested from previous studies of RD. These findings support the idea that common genes may underlie ADHD and RD but also that reading ability and RD have genetic underpinnings that differ from those underlying ADHD as well. However, since each region that overlaps ADHD and reading ability harbors hundreds of genes, further work is required to identify specific genetic variants underlying ADHD and RD and to determine if they are actually the same or different.


'"/>

Contact: Aimee Midei
molecularpsychiatry@mednet.ucla.edu
310-206-6739
Molecular Psychiatry
11-Dec-2003


Page: 1

Related biology news :

1. Reading hexametric rhyme supports cardiac synchronization, especially after a heart attack
2. Reading the brain
3. Gene-Reading Problem Linked To Lou Gehrigs Disease
4. Cardiac arrest may hinder ability to learn certain tasks
5. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
6. Evolvability could be a driving force in drug resistance
7. Climate may play role in lynxs hunting ability
8. Study: Artificial sweetener may disrupt bodys ability to count calories
9. Oak Ridge National Laboratory to develop DOE leadership-class computing capability for science
10. ASU advance could provide insight into humans ability to recognize patterns
11. Molecular mechanism found that may improve ability of stem cells to fight disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: