HOME >> BIOLOGY >> NEWS
Recent evolution at a single gene may have brought down heart disease risk in some human groups

Heart disease is Europe's leading cause of death, but new research shows that the disease's toll would be much greater had natural selection not shifted the frequency of susceptibility genes over the past few tens of thousands of years. The work underscores the role of ancient natural selection in shaping contemporary public health.

The findings are reported by Matthew Rockman, Dagan Loisel, and Greg Wray at Duke University, Matthew Hahn at UC Davis, and David Goldstein and Nicole Soranzo at University College London. By analyzing DNA sequences from humans and other primates and comparing sequences among and within human populations, the researchers have cast light on the evolutionary history of a single DNA base pair that has been shown to influence heart disease.

The genetic trait under study concerns a particular base pair of DNA one of billions in the human genome that helps regulate the gene stromelysin-1, or MMP-3. The identity of the DNA base at this position differs between individuals and influences the rate of production of the gene's product, an enzyme that degrades the extracellular matrix that makes up the walls of arteries.

Individuals with the low-expression version of the gene are slightly more prone to atherosclerosis, the narrowing of the arteries associated with the accumulation of plaque in the arterial walls. The new research shows that the high-expression variant increased rapidly in frequency in the ancient European population, though not elsewhere. The rapid increase, which is estimated to have begun around 24,000 years ago, is attributable to the action of natural selection favoring the variant, according to statistical analyses of genetic variation in several human populations.

The researchers' new work also showed that the mutation that created the variant occurred at a site unusually prone to genetic change. By comparing human DNA with that of a diverse range of other primates, they showed that the var
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
6-Sep-2004


Page: 1 2

Related biology news :

1. Recent USGS Work In New England And Beyond
2. Belgian researchers explore revolutionary approach to angiogenesis
3. Pack-MULEs are toting a new look at plant evolution
4. K-State, other universities to study how climate affects plant evolution
5. Genetic analysis rewrites salamanders evolutionary history
6. Heart gene yields insights into evolution, disease risk
7. Broken arms and collateral damage: clues to predator-driven evolution
8. Battle between bubbles might have started evolution
9. Prions act as stepping stones in evolution
10. Study suggests humans can speed evolution
11. Researchers review evolutionary history of modern algae

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/19/2019)... ... August 19, 2019 , ... Since ... use of ultra-thin two dimensional slices which are placed on microscope slides, stained ... complex tissues and complicated features such as vasculature and thus researchers in the ...
(Date:8/15/2019)... ... ... Deep Science Ventures (DSV), a new paradigm for applied science, today announced ... 100 companies over the next 10 years to address the urgent need for new ... was founded to create a better method for launching science companies; one that takes ...
(Date:8/15/2019)... ... , ... Serialization deadlines in the US and European Union ... becomes fully applied in the United States in 2023, pharmaceutical companies are scrutinizing ... most regulations?including the Drug Supply Chain Security Act (DSCSA)?have required minimal system capabilities. ...
Breaking Biology News(10 mins):
(Date:8/15/2019)... ... August 15, 2019 , ... PathSensors announced today that Roger ... of the Institute of Food Technologists (IFT) Board of Directors, Illinois Institute of ... for Food Safety and Applied Nutrition (JIFSAN) Advisory Council and the University of ...
(Date:8/14/2019)... STATE COLLEGE, Pa. (PRWEB) , ... August 13, ... ... leader in nuclear receptor and in vitro toxicology testing solutions, announced the appointment ... of healthcare industry experience to the Board. , Mark McLoughlin will lend his ...
(Date:8/14/2019)... ... August 13, 2019 , ... ... prepackaged mobile phases for QC laboratories. After gaining a few significant clients, Lifecycle ... approach into a valued supplier of manufacturing processing solutions, including reagents for tissue ...
(Date:8/8/2019)... , ... August 08, 2019 , ... ... Agents for sales and service organizations, today announced that the company’s Studio ... Award for the IVA market . Inference will officially accept the award at ...
Breaking Biology Technology:
Cached News: