HOME >> BIOLOGY >> NEWS
Receptor May Increase Risk Of Urinary Tract Infections

A newly discovered chemical compound on the surface of some women's kidney cells may explain susceptibility to urinary tract infections, according to current research in the journal Biochemistry. The structure, a specific type of compound known as a glycosphingolipid, is suspected to be on urogenital tract cells in about 30% of all men and women and binds strongly to E. coli bacteria.

The research is outlined in the Nov. 21 web edition of Biochemistry, a peer-reviewed journal of the American Chemical Society, the world's largest scientific society. The article will appear in the journal's Dec. 15 print publication.

Previous studies have shown that women without ABO blood group antigens in their bodily secretions are more likely to have recurrent urinary tract infections. These women are missing the biochemical tools that put the finishing touches on a certain chemical called a glycolipid to determine blood type. "So that glycolipid becomes modified in a different way," says lead author Mark R. Stroud, Ph.D. at Northwest Hospital and the University of Washington in Seattle, "and that modification results in a compound that acts as a high affinity receptor for E. coli The big story here is that the compound itself has been identified." The compound, called sialosyl galactosyl globoside or SGG, had previously only been found in some animal cells and human cells in early stages of embryonic development.

E. coli bacteria are responsible for more than 90% of urinary tract infections, which affect an estimated 7 million women each year at a cost exceeding one billion dollars for diagnosis and treatment. Finding this bacteria-binding compound on kidney cells and the researchers have strong evidence it is on other cells lining the urogenital tract as well may provide a strategy to better treat women prone to infection, who often have to take antibiotics constantly.

Those treatment regimens "basically turn someone who is otherwise normal i
'"/>

Contact: Nancy Blount
n_blount@acs.org
202-872-4440
American Chemical Society
11-Dec-1998


Page: 1 2

Related biology news :

1. Receptor found that guides nerve cells to their final connecting sites
2. Receptor could be target for cancer therapy
3. Receptor-dependent protein activation without a receptor
4. Researchers Engineer A Way To Improve T-Cell Receptors
5. Studies At Cedars-Sinai Confirm Identity Of An Elusive Receptor In Human Cells -- A Breakthrough In Understanding, Fighting Septic Shock
6. Scientists Discover Function For Type III TGF-Beta Receptor
7. Antiviral From Advanced Viral Research Corp. Inhibits CCR5 Cell Receptor For HIV
8. Allelix Clones Receptor For Intestinal Growth Factor GLP-2
9. Scientists Discover Key Cog In Receptor That Governs Ripening
10. UCSF/Gladstone Finding May Explain HIVS Ability To Infect Cells Lacking The Key Target Of HIV: The CD4 Receptor
11. New Findings On Receptor Regulation May Lead To Better Drugs For Diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... India , March 23, 2017 The report "Gesture ... Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, ... at a CAGR of 29.63% between 2017 and 2022. ... ... ...
(Date:3/20/2017)... 2017 At this year,s CeBIT Chancellor Dr. ... DERMALOG. The Chancellor came to the DERMALOG stand together with the Japanese ... CeBIT partner country. At the largest German biometrics company the two government ... and iris recognition as well as DERMALOGĀ“s multi-biometrics system.   ... ...
(Date:3/9/2017)... and MOUNTAIN VIEW, Calif. , ... Well Made Simple," and 23andMe , the leading ... better food choices.  Zipongo can now provide customers with ... preferences, health goals and biometrics, but also genetic markers ... choices. Zipongo,s personalized food decision support platform ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... ... April 20, 2017 , ... Open Therapeutics and ... (IP) sharing and commercialization model. , The Center for Advancing Innovation helps institutions ... this effort is bringing the IP to the attention of the entrepreneurial community ...
(Date:4/19/2017)... ... 18, 2017 , ... The Vibrating Orifice Aerosol Generator (VOAG) ... monodisperse droplets of known diameters for research applications such as for calibrating droplet ... drying monodisperse droplets. , The VOAG requires forcing liquid out of an ...
(Date:4/19/2017)... ... April 19, 2017 , ... Nobilis Therapeutics Announces Completion of ... Leverage Clinical Data in its Upcoming Post Traumatic Stress Disorder Trial , Nobilis ... clinical trial assessing efficacy of its NBTX-001, a xenon-based therapeutic in the treatment of ...
(Date:4/19/2017)... , April 19, 2017 A new report published ... Industry Forecast, 2014-2022 ," the global market was valued at $6,769 million in ... of 9.6% from 2016 to 2022. ... Allied Market Research ...      (Logo: http://photos.prnewswire.com/prnh/20140911/647229) ...
Breaking Biology Technology:
Cached News: