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Receptor May Increase Risk Of Urinary Tract Infections

nto having a chronic disease," says co-author and University of Washington Associate Professor of Medicine Ann E. Stapleton, M.D.. "They have to take something, often for the rest of their lives, if they want to be free of infection." Such long-term use of medicines can also create resistant strains of bacteria.

Now that scientists know the structure of SGG, "we'd like to use this as a model to create something that can then inhibit E. coli from binding," says Stroud. While cautioning that such a strategy is a long-term goal, Stapleton adds: "What we hope to do is to see whether or not competitive inhibition at the mucosal level would have some effect on prevention or, perhaps, augmentation of treatment." The researchers believe that since the bacteria wouldn't be killed just washed away mutants, and thus resistance, would not develop.


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Contact: Nancy Blount
n_blount@acs.org
202-872-4440
American Chemical Society
11-Dec-1998


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