HOME >> BIOLOGY >> NEWS
Receptor could be target for cancer therapy

Tumor cells have evolved a crafty scheme for protecting themselves from the killing power of the host immune system; in part, they disable the immune response.

New studies from a group of Vanderbilt University Medical Center investigators implicate a receptor for prostaglandin E2 (PGE2) in this phenomenon of tumor-induced immune suppression.

The findings, published in the March 1 Journal of Clinical Investigation, suggest that drugs that block the PGE2 receptor, called EP2, might restore the immune system's tumor-killing capacity.

"In two different transplantable tumor models in mice, it looks like the EP2 receptor is a key mediator of the tumor's immunosuppressive action," said Richard M. Breyer, Ph.D., associate professor of Medicine and Pharmacology.

The team of investigators, including Breyer, Dr. David P. Carbone, Ingram Professor of Cancer Research at the Vanderbilt-Ingram Cancer Center, and graduate student Li Yang, injected colon and lung cancer cells into two groups of mice -- normal mice and mice lacking the EP2 receptor (EP2 knockout mice). Tumors were smaller in the EP2 knockout mice, and these mice survived for longer periods of time compared to control mice.

"Not having an EP2 receptor appears to slow cancer growth and improve survivability," Breyer said. The researchers tracked the EP2 receptor effect to a difference in immune system function -- the EP2 knockout mice appeared to mount an effective tumor-killing immune response; the control mice did not.

Breyer's focus on the EP2 receptor stems from his long-standing interest in the biological effects of prostaglandins, a family of locally acting hormones produced by the cyclooxygenase (COX) enzymes. COX enzymes are the targets of aspirin and other non-steroidal anti-inflammatory drugs, which work to relieve pain and inflammation by blocking the production of prostaglandins.

The connection between COX and cancer was made in the early 1990s, Breyer said, when researc
'"/>

Contact: Clinton Colmenares
clinton.colmenares@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
5-Mar-2003


Page: 1 2 3

Related biology news :

1. Receptor found that guides nerve cells to their final connecting sites
2. Receptor-dependent protein activation without a receptor
3. Researchers Engineer A Way To Improve T-Cell Receptors
4. Studies At Cedars-Sinai Confirm Identity Of An Elusive Receptor In Human Cells -- A Breakthrough In Understanding, Fighting Septic Shock
5. Scientists Discover Function For Type III TGF-Beta Receptor
6. Antiviral From Advanced Viral Research Corp. Inhibits CCR5 Cell Receptor For HIV
7. Allelix Clones Receptor For Intestinal Growth Factor GLP-2
8. Scientists Discover Key Cog In Receptor That Governs Ripening
9. UCSF/Gladstone Finding May Explain HIVS Ability To Infect Cells Lacking The Key Target Of HIV: The CD4 Receptor
10. Receptor May Increase Risk Of Urinary Tract Infections
11. New Findings On Receptor Regulation May Lead To Better Drugs For Diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... 2017 Delta (NYSE: DAL ) customers now can ... at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan ... Delta,s biometric boarding pass experience that ... now integrated into the boarding process to allow eligible Delta SkyMiles Members ...
(Date:6/14/2017)... 15, 2017  IBM (NYSE: IBM ) is introducing several ... dedicated to developing collaboration between startups and global businesses, taking ... During the event, nine startups will showcase the solutions they ... industries. France is ... with a 30 percent increase in the number of startups ...
(Date:5/16/2017)... May 16, 2017   Bridge Patient Portal ... and MD EMR Systems , an electronic ... for GE, have established a partnership to build ... and the GE Centricity™ products, including Centricity Practice ... These new integrations will allow healthcare ...
Breaking Biology News(10 mins):
(Date:10/7/2017)... ... October 06, 2017 , ... ... instruments and applications consulting for microscopy and surface analysis, Nanoscience Instruments is ... Nanoscience Analytical offers a broad range of contract analysis services for advanced ...
(Date:10/7/2017)... , Oct. 6, 2017  The 2017 ... of three scientists, Jacques Dubochet, Joachim Frank ... developments in cryo-electron microscopy (cryo-EM) have ... within the structural biology community. The winners worked ... can now routinely produce highly resolved, three-dimensional images ...
(Date:10/6/2017)... Washington, D.C. (PRWEB) , ... October 06, 2017 ... ... Cure) will host a lunch discussion and webinar on INSIGhT, the first-ever adaptive ... INSIGhT Principal Investigator, Dana-Farber Cancer Institute. The event is free and open to ...
(Date:10/5/2017)... ... 05, 2017 , ... Understanding the microbiome, the millions of bacteria that live ... You Are My Future, the newest exhibit on display at the University City Science ... condition through the lens of the gut microbiome. , Gut Love opens October ...
Breaking Biology Technology:
Cached News: