HOME >> BIOLOGY >> NEWS
Receptor-dependent protein activation without a receptor

Activation of G-Proteins was previously thought to be exclusively triggered by extracellular stimuli. Now Dr. Jrgen Knoblich and his group at the Research Institute of Molecular Pathology, Vienna (Austria), provide in vivo evidence for G-Protein activation solely by an intracellular protein.

"G-Protein activation was predominantly seen as a "relay station integrating extracellular signals via membrane spanning receptors with intracellular responses. The central role of this activation in cell responses to hormones and neurotransmitters makes G-proteins a major target for a wide range of powerful pharmaceuticals in humans. However, we now believe that a cellular mechanism exists which can activate these key proteins without extracellular stimulation. This fundamental insight could help gaining better understanding of disease mechanisms and will aid the development of novel therapies comments Dr. Knoblich.

Published in tomorrows issue of Cell (Vol. 107/2). the work by Knoblich describes a role for the cellular protein Pins (Partner of Inscuteable) in the localised activation of G-proteins in asymmetrically dividing cells of the developing Drosophila nervous system. Autonomous activation of G-proteins is shown to be part of a synchronised interaction of several proteins in differentiating neuroblasts. The receptor-independent activation of G-proteins is believed to support cellular polarity not only in neuroblasts but also in precursor cells of sensory organs (SOPs). Such establishment and maintenance of cellular polarity is essential for correct differentiation of these cells after delamination from adjacent tissue.

Previous work by Stephen Lanier and colleagues at the Medical University of South Carolina showed that Pins are conserved in humans and can activate G-proteins under controlled in vitro conditions. Taken together with the in vivo data from Drosophila reported here it is believed that receptor-independent G-protein activation plays an
'"/>

Contact: Heidemarie Hurtl
hurtl@imp.univie.ac.at
43-1-79730-358
PR&D Public Relations for Research & Development
18-Oct-2001


Page: 1 2

Related biology news :

1. New molecular link key to cellular proteins involved in cancer progression, other diseases
2. Researchers identify protein promoting vascular tumor growth
3. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
4. Experimental drug shown to block mutant protein causing blood disease
5. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
6. Images of tail of protein needed for cell multiplication suggest anticancer drug targets
7. New dye directly reveals activated proteins in living cells
8. Disruption of protein-folding causes neurodegeneration, mental retardation
9. A new protein is discovered to play a key role in cancer progression
10. Optimizing proteins death domain halts leukemia in laboratory study
11. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2019)... ... , ... Experiential tourism, a trend encompassing culinary travel, cultural exploration and activity-based ... And according to a recent report by Skift, a media company for the travel ... travelers are wanting their journeys to be authentic and unique, and good cuisine has ...
(Date:5/21/2019)... , ... May 20, 2019 , ... Dr. David ... acclaimed documentary. The documentary, Stem Cell Therapy: Biotechnology to the Rescue, was produced by ... long, Dr. Greene was interviewed in regards to the safety of the procedures along ...
(Date:5/21/2019)... ... ... At their May 16 meeting, the members of the F04.43 Subcommittee on Cells and ... for Testing and Materials International voted unanimously to approve an interlaboratory study proposed ... company’s plan to establish its AlphaSTEM Test™ stem cell counting technology as ...
Breaking Biology News(10 mins):
(Date:4/25/2019)... ... April 24, 2019 , ... ... for sales and service organizations, today announced global availability of Inference Studio’s latest ... enterprises of all sizes to harness the power of Google’s Contact Center ...
(Date:4/16/2019)... ... April 16, 2019 , ... Fulcrum Biometrics ... announced that Bank South Pacific (BSP), the largest regionally owned bank in the ... Fulcrum a contract to deliver a fingerprint-based Know Your Customer (KYC) banking solution ...
(Date:4/10/2019)... ... April 10, 2019 , ... RoosterBio ... multiple agreements to help companies advance their innovations to clinical testing more ... synthetic biology companies that are gene editing therapeutic cells for advanced functionality ...
(Date:4/9/2019)... ... April 09, 2019 , ... Sonny Bar Lisa, or ... limb for approximately two months. After a series of diagnostics, an MRI was ... Sonny’s owner, Alison, researched the injury and found that VetStem Regenerative Cell Therapy ...
Breaking Biology Technology:
Cached News: