Recombinant Protein Immunizes Mice, Promises New Strategy Against Infection And Cancer

oy the germs circulating in the bloodstream. However, antibodies are useless when it comes to penetrating cells. The task of attacking cells infected by viruses or deformed by cancer falls to the second arm of the immune system, led by immune cells called T cells. T cells orchestrate a multi-pronged attack, and if appropriate, turn into 'killer cells,' called cytotoxic T cells or CTLs, that home in on infected cells and destroy them.

The goal of vaccine development is to produce a full-blown immune response without causing full-blown disease. However, when vaccines containing soluble proteins from the microorganisms are used to produce an immune response, the CTLs are rarely activated.

For decades, vaccine development experts have sought to find a simple and practical way to activate the killer cells or CTLs using soluble proteins, but finding a method that works has been a challenge.

"We were able to solve this problem by taking advantage of the observation that a class of proteins, called heat-shock proteins, are exceptions to the rule that soluble proteins are unable to stimulate CTL responses. In fact, heat-shock proteins are extremely potent in stimulating a CTL immune response," says Dr. Young.

Heat shock proteins, or stress proteins, are a family of proteins that cells produce in response to stress from heat, injury, germs, or toxins. Normally, these proteins act as molecular chaperones, binding to other proteins and ferrying them to and from various compartments of the cell. A few years ago, immunologists noticed that heat shock proteins are present on the surface of bacteria and are responsible for flagging the T cells and triggering the CTLs to attack.

Dr. Young and his colleagues found one particular protein from the tuberculosis bacterium, called hsp70, that could elicit powerful immune responses and could be used as an immune system booster. The special properties of hs

Contact: Seema Kumar or Eve Nichols
kumar@wi.mit.edu, nichols@wi.mit.edu
(617) 258-5183
Whitehead Institute for Biomedical Research

Page: 1 2 3

Related biology news :

1. Recombinant Protein Expression Lab established at CU
2. Recombinant yeast as an antifungal vaccine
3. Recombinant protein may play key role in treating immunocompromised patients
4. Virginia Tech Scientists To Evaluate Risks Associated With Release of Recombinant Organisms
5. Protein is key to fatal disorder and normal cell function
6. Protein is key for digestive function of the pancreas
7. Proteins show promise for mosquito control
8. Protein involved in childhood disorder linked to cancer
9. Protein fishing in America: The movie
10. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
11. Protein key to trafficking in nerve terminals

Post Your Comments:

(Date:5/24/2016)... 24, 2016 Ampronix facilitates superior patient care by providing unparalleled technology to ... display is the latest premium product recently added to the range of products distributed ... ... ... Imaging- LCD Medical Display- Ampronix News ...
(Date:5/3/2016)... 2016  Neurotechnology, a provider of high-precision biometric ... Biometric Identification System (ABIS) , a complete system ... ABIS can process multiple complex biometric transactions with ... fingerprint, face or iris biometrics. It leverages the ... MegaMatcher Accelerator , which have been used ...
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... 2016 , ... Parallel 6 , the leading software as a service ... Virtual Patient Encounter CONSULT module which enables both audio and video telemedicine communication ... , Using the CONSULT module, patients and physicians can schedule a face to face ...
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former senior ... the University of North Carolina Kenan-Flagler Business School effective June 27. ... Kenan-Flagler, with a focus on the school’s international efforts, leading classes and participating ...
(Date:6/27/2016)... 27, 2016   Ginkgo Bioworks , a leading ... was today awarded as one of the World ... world,s most innovative companies. Ginkgo Bioworks is engineering ... real world in the nutrition, health and consumer ... with customers including Fortune 500 companies to design ...
(Date:6/24/2016)... 2016 Epic Sciences unveiled a liquid ... to PARP inhibitors by targeting homologous recombination deficiency ... new test has already been incorporated into numerous ... types. Over 230 clinical trials are ... including PARP, ATM, ATR, DNA-PK and WEE-1. Drugs ...
Breaking Biology Technology:
Cached News: