HOME >> BIOLOGY >> NEWS
Recombinant Protein Immunizes Mice, Promises New Strategy Against Infection And Cancer

oy the germs circulating in the bloodstream. However, antibodies are useless when it comes to penetrating cells. The task of attacking cells infected by viruses or deformed by cancer falls to the second arm of the immune system, led by immune cells called T cells. T cells orchestrate a multi-pronged attack, and if appropriate, turn into 'killer cells,' called cytotoxic T cells or CTLs, that home in on infected cells and destroy them.

The goal of vaccine development is to produce a full-blown immune response without causing full-blown disease. However, when vaccines containing soluble proteins from the microorganisms are used to produce an immune response, the CTLs are rarely activated.

For decades, vaccine development experts have sought to find a simple and practical way to activate the killer cells or CTLs using soluble proteins, but finding a method that works has been a challenge.

"We were able to solve this problem by taking advantage of the observation that a class of proteins, called heat-shock proteins, are exceptions to the rule that soluble proteins are unable to stimulate CTL responses. In fact, heat-shock proteins are extremely potent in stimulating a CTL immune response," says Dr. Young.

Heat shock proteins, or stress proteins, are a family of proteins that cells produce in response to stress from heat, injury, germs, or toxins. Normally, these proteins act as molecular chaperones, binding to other proteins and ferrying them to and from various compartments of the cell. A few years ago, immunologists noticed that heat shock proteins are present on the surface of bacteria and are responsible for flagging the T cells and triggering the CTLs to attack.

Dr. Young and his colleagues found one particular protein from the tuberculosis bacterium, called hsp70, that could elicit powerful immune responses and could be used as an immune system booster. The special properties of hs
'"/>

Contact: Seema Kumar or Eve Nichols
kumar@wi.mit.edu, nichols@wi.mit.edu
(617) 258-5183
Whitehead Institute for Biomedical Research
25-Nov-1997


Page: 1 2 3

Related biology news :

1. Recombinant Protein Expression Lab established at CU
2. Recombinant yeast as an antifungal vaccine
3. Recombinant protein may play key role in treating immunocompromised patients
4. Virginia Tech Scientists To Evaluate Risks Associated With Release of Recombinant Organisms
5. Protein is key to fatal disorder and normal cell function
6. Protein is key for digestive function of the pancreas
7. Proteins show promise for mosquito control
8. Protein involved in childhood disorder linked to cancer
9. Protein fishing in America: The movie
10. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
11. Protein key to trafficking in nerve terminals

Post Your Comments:
(Date:6/16/2015)... , June 16, 2015 /CNW Telbec/ - ... partnership centralized around the incorporation of handyem,s HPC-150 ... diagnostic laboratory, the Mo-POD™. This unprecedented model of ... International Conference at the Pennsylvania ... from June 15 th to 18 th ...
(Date:6/16/2015)... Fingerprint Cards (FPC) raises the revenue guidance for ... at least 340 MSEK to that it will amount to ... growth and orders received the revenue guidance for 2015 is ... will exceed 1,500 MSEK to an updated guidance that revenue ... Due to receipt of orders of touch fingerprint sensors with ...
(Date:6/15/2015)... --NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") ... market, announces that its leading payment security technology, the Wocket® ... @ NYC June 18th. Digital Experience! @ NYC ... technology to over 300 of the top media covering the ... in New York City from 6:00 ...
Breaking Biology News(10 mins):handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 3
(Date:6/29/2015)... Pharnext SAS today announced that data related to its ... Type 1A (CMT1A), is being presented in four posters and ... Biennial Meeting at the Quebec Congress Center in ... 2015. At Poster Viewing Session 4, four posters ... EDT: Poster 23: "A Meta-Analysis Of Randomized ...
(Date:6/29/2015)... June 29, 2015  MiMedx Group, Inc. (NASDAQ: ... amniotic tissue and patent-protected processes to develop and market ... Orthopedic, Spine, Sports Medicine, Ophthalmic and Dental sectors of ... "Pete" Petit, has been awarded the Lifetime Achievement Award ... Program. The Entrepreneur Of The Year ...
(Date:6/29/2015)... --  For the seventh year running, Across Health conducted a ... maturity called the Multichannel Maturometer . The research ... fast enough. While it,s true that technology is indeed ... customers are increasingly "digital natives", pharma still lags behind ... Logo ...
(Date:6/26/2015)... ... June 26, 2015 , ... ... Agriculture (USDA), Grain Inspection, Packers and Stockyards Administration (GIPSA) awarded a five year ... in feed and grains utilizing Charm’s ROSA DONQ-FAST5 Test. This 5 minute quantitative ...
Breaking Biology Technology:Pharnext's PXT-3003 Featured in Multiple Presentations at 2015 Peripheral Nerve Society Biennial Meeting 2EY Entrepreneur Of The Year Program Recognizes Pete Petit, The Chairman & CEO of MiMedx 2Results from Digital Maturity Study Show Pharma Lagging 2Results from Digital Maturity Study Show Pharma Lagging 3Results from Digital Maturity Study Show Pharma Lagging 4USDA-GIPSA (FGIS) Awards 5 Year Contract for Vomitoxin Tests to Charm Sciences 2
Cached News: