Recombinant yeast as an antifungal vaccine

Despite the long and successful history of vaccine use, primarily for viral diseases, fungal pathogens have only rarely been considered as targets for vaccination. To date, only one antifungal vaccine, designed to prevent ringworm in cattle, has progressed beyond the experimental stage. Wthrich et al. now describe the use of a live attenuated strain of Blastomyces dermatitidis to prevent blastomycosis, an often-fatal yeast infection of the lung. Mice immunized with killed wild-type B. dermatitidis mount an immune response to one of its major cell surface adhesion proteins, WI-1, but they are only weakly protected when challenged with the live pathogen. Wthrich and coworkers previously took advantage of the tractable genetics of this yeast to create a strain lacking the WI-1 gene, showing that this strain could not propagate or cause disease in mice Here, they report that live WI-1- yeast provoke a T cell response that protects inoculated animals from infection with wild-type B. dermatitidis. Crucially, this protection applies not only against yeast that are isogenic to the attenuated strain, but also to several unrelated pathogenic isolates. The authors also show that fungal cell wall preparations derived from the WI-1- strain also protect mice from lung infections, raising the possibility that, as with the live attenuated organism, one or more purified fungal components could be used as an effective vaccine.


Contact: John Ashkenas
Journal of Clinical Investigation

Page: 1

Related biology news :

1. Recombinant Protein Expression Lab established at CU
2. Recombinant protein may play key role in treating immunocompromised patients
3. Virginia Tech Scientists To Evaluate Risks Associated With Release of Recombinant Organisms
4. Recombinant Protein Immunizes Mice, Promises New Strategy Against Infection And Cancer
5. Purdue yeast makes ethanol from agricultural waste more effectively
6. Carnegie Mellon U biologists identify critical player in yeast ribosome assembly
7. Protein-only prions confirmed in FSU yeast study
8. Bakers yeast rises from genome duplication
9. Building a better atlas of yeast proteins
10. New findings in yeast may reveal why growing older is the greatest carcinogen in humans
11. Dartmouth bioengineers develop humanized yeast

Post Your Comments:

(Date:3/3/2020)... ... ... Amplify Surgical, Inc., today announces that the company reached the milestone of ... The landmark case was performed by Dr. Ali Najafi at Fresno Heart and Surgical ... changed the game for expandable interbodies. The ability to achieve an ALIF sized ...
(Date:3/2/2020)... PHILADELPHIA (PRWEB) , ... March 02, 2020 , ... Philadelphia ... Travis W. Bliss, Ph.D., J.D. has joined the firm as a Partner, and Stephany ... Bliss is an experienced patent attorney and will be a partner in the firm’s ...
(Date:2/28/2020)... ... February 28, 2020 , ... Meridian Clinical Research , a ... Excellence (ViE) award for Best Clinical Trial Site. Meridian is also the largest ... Clinical Trial Network award. These nominations were the result of two voting rounds, and ...
Breaking Biology News(10 mins):
(Date:3/10/2020)... , ... March 10, 2020 , ... Lifecycle Biotechnologies ... 13 acres in Cleburne, Texas to be used as a biopharmaceutical and biotechnology production ... headquarters and sales offices as well as its production and development hub. The company ...
(Date:3/3/2020)... ... March 03, 2020 , ... Frictionless ... and medical device industries, was recognized by INC. 5,000 on an annual list ... to note industry leaders greatly impacting their spheres of influence and experiencing considerable ...
(Date:2/28/2020)... ... February 26, 2020 , ... Designed primarily for ... with a dedicated controller, thus simplifying setup, streamlining integration, and optimizing workflow. Capable ... first of Fastec Imaging’s new HS Series cameras to be released. The HS ...
(Date:2/21/2020)... ... February 20, 2020 , ... ... perform complex, efficient and elegant chemistry. Humans have been increasingly successful in ... goals. , Through rapidly evolving technologies and strategies for modern molecular biology ...
Breaking Biology Technology:
Cached News: