HOME >> BIOLOGY >> NEWS
Recovery from spinal cord injury seen in mice when scarring is minimized

PHILADELPHIA - Severe injury to the spinal cord can lead to devastating loss of function, and subsequent recovery is often minimal. Accordingly, the factors that inhibit recovery have been a major research focus in recent years. Might there be ways to promote regeneration of the cells in the spinal cord or otherwise encourage a restoration of function following injury?

A new study conducted in mice by researchers at The Wistar Institute suggests that the key to recovery from severe spinal-cord injury may lie in limiting the scarring process that generally follows such an injury, rather than in an enhanced regenerative capacity.

In mice where the ability of inflammatory cells to reach the injury site was physically limited, the formation of scar tissue at the site was also limited, the scientists found in their experiments. Without the physical barrier of scar tissue to impede their progress, neurons on both sides of the injury site were able to grow and reestablish connections with each other over a period of two to three weeks, leading to substantial recovery of function. A report on the study appears in the February 1 issue of the Journal of Neuroscience Research.

"The problem in recovery from spinal-cord injury appears to be the scar tissue that forms in response to injury," says Ellen Heber-Katz, Ph.D., a professor at The Wistar Institute and senior author on the study. "The scar eliminates the ability of neurons to regrow their axons across the injury site. It's an absolute physical block. We found, however, that if you prevent the scar tissue from forming, the mice recover from their injuries."

The findings show that physically preventing scar tissue from forming can open the way for recovery from spinal-cord injury, according the Heber-Katz.

More clinically relevant, perhaps, is that the research also suggests that drugs able to biochemically block scar-tissue formation immediately following such an injury might have
'"/>

Contact: Franklin Hoke
hoke@wistar.upenn.edu
215-898-3716
The Wistar Institute
22-Jan-2002


Page: 1 2

Related biology news :

1. Endangered Species Recovery Plans Face Comprehensive Scientific Review
2. Major Set-Back To Ozone Layer Recovery
3. USGS Measures Coral Reef Recovery In Culebra, Puerto Rico
4. Circulatory Device -- A Bridge To Recovery For Heart Failure?
5. Recovery From Mass Extinction Is Unexpectedly Diverse
6. Eating After Exertion May Be A Key To Speeding Bodys Recovery
7. A Phoenix From A Ring Of Fire Is A Pattern For The Recovery Of Mount St. Helens
8. Nerve cells guided to repair spinal damage: Technique
9. Mitochondria in spinal cords is ALS target according to UCSD medical researchers
10. Yale researchers receive $4.5 million grant to study spinal cord repair
11. Study of ProCord for neurologically complete spinal cord injury

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2017)... , March 21, 2017   Neurotechnology , ... recognition technologies, today announced the release of the ... which provides improved facial recognition using up to ... a single computer. The new version uses deep ... accuracy, and it utilizes a Graphing Processing Unit ...
(Date:3/16/2017)... 2017 CeBIT 2017 - Against identity fraud with DERMALOG solutions "Made ... ... Used combined in one project, multi-biometric solutions provide a crucial contribution against identity ... Used combined in one project, multi-biometric ... ...
(Date:3/7/2017)... CITY , March 7, 2017   HireVue ... help top global companies identify the best talent, faster, ... as Chief Sales Officer (CSO) and Diana Kucer ... appointments round out a seasoned executive team poised to drive ... beyond, building on a year of record bookings in ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... monitoring solutions, today announced the hire of Dr. Sigmund “Sig” Floyd as Vice ... applications, strategic partnerships and joint development activities. , “Dr. Floyd’s career has spanned ...
(Date:3/22/2017)... , March 22, 2017 Good Start ... it has eclipsed the 130 million covered lives mark ... Shield of Texas . With newly ... Company continues to enjoy strong payor acceptance based on ... clinical programs and genetic counseling, its industry-leading customer care ...
(Date:3/22/2017)... 22, 2017 /PRNewswire/ - FACIT announced a seed ... "Propellon"), a start-up created by FACIT focused on ... investment, combined with non-dilutive capital, achieves a targeted ... funding enables Propellon to accelerate the nomination of ... financing and/or entering a strategic partnership for clinical ...
(Date:3/22/2017)... ... March 21, 2017 , ... Proper ... information on the desired increase and/or decrease in antibody-dependent cellular cytotoxicity or complement-dependent ... profiling of therapeutic antibodies. , To meet this demand, the team at ...
Breaking Biology Technology:
Cached News: