HOME >> BIOLOGY >> NEWS
Recovery from spinal cord injury seen in mice when scarring is minimized

PHILADELPHIA - Severe injury to the spinal cord can lead to devastating loss of function, and subsequent recovery is often minimal. Accordingly, the factors that inhibit recovery have been a major research focus in recent years. Might there be ways to promote regeneration of the cells in the spinal cord or otherwise encourage a restoration of function following injury?

A new study conducted in mice by researchers at The Wistar Institute suggests that the key to recovery from severe spinal-cord injury may lie in limiting the scarring process that generally follows such an injury, rather than in an enhanced regenerative capacity.

In mice where the ability of inflammatory cells to reach the injury site was physically limited, the formation of scar tissue at the site was also limited, the scientists found in their experiments. Without the physical barrier of scar tissue to impede their progress, neurons on both sides of the injury site were able to grow and reestablish connections with each other over a period of two to three weeks, leading to substantial recovery of function. A report on the study appears in the February 1 issue of the Journal of Neuroscience Research.

"The problem in recovery from spinal-cord injury appears to be the scar tissue that forms in response to injury," says Ellen Heber-Katz, Ph.D., a professor at The Wistar Institute and senior author on the study. "The scar eliminates the ability of neurons to regrow their axons across the injury site. It's an absolute physical block. We found, however, that if you prevent the scar tissue from forming, the mice recover from their injuries."

The findings show that physically preventing scar tissue from forming can open the way for recovery from spinal-cord injury, according the Heber-Katz.

More clinically relevant, perhaps, is that the research also suggests that drugs able to biochemically block scar-tissue formation immediately following such an injury might have
'"/>

Contact: Franklin Hoke
hoke@wistar.upenn.edu
215-898-3716
The Wistar Institute
22-Jan-2002


Page: 1 2

Related biology news :

1. Endangered Species Recovery Plans Face Comprehensive Scientific Review
2. Major Set-Back To Ozone Layer Recovery
3. USGS Measures Coral Reef Recovery In Culebra, Puerto Rico
4. Circulatory Device -- A Bridge To Recovery For Heart Failure?
5. Recovery From Mass Extinction Is Unexpectedly Diverse
6. Eating After Exertion May Be A Key To Speeding Bodys Recovery
7. A Phoenix From A Ring Of Fire Is A Pattern For The Recovery Of Mount St. Helens
8. Nerve cells guided to repair spinal damage: Technique
9. Mitochondria in spinal cords is ALS target according to UCSD medical researchers
10. Yale researchers receive $4.5 million grant to study spinal cord repair
11. Study of ProCord for neurologically complete spinal cord injury

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Recovery from spinal cord injury seen mice when scarring minimized

(Date:4/17/2014)... April 17, 2014The development of stem cell therapies to ... to characterize stem cell populations based on cell surface ... a new marker that is highly expressed in a ... blood, which they describe in an article in ... Ann Liebert, Inc., publishers. The article is available free ...
(Date:4/17/2014)... in about one per eight hundred births, Down syndrome ... genetic cause of intellectual disability. It results from a ... third copy of chromosome 21 (1% of the human ... team in the Department of Genetic Medicine and Development ... published in Nature , shed light on how ...
(Date:4/17/2014)... The White House honored Clemson professor Rajendra Singh ... efforts to promote and expand solar deployment in ... the D. Houser Banks Professor of Electrical and ... Silicon Nanoelectronics, is considered a local hero leading ... and economic opportunity in solar power and driving ...
Breaking Biology News(10 mins):Trisomy 21: How an extra little chromosome throws the entire genome off balance 2Trisomy 21: How an extra little chromosome throws the entire genome off balance 3White House honors Clemson professor as 'Champion of Change' for solar deployment 2
(Date:1/15/2014)... NY (PRWEB) January 15, 2014 The Microcompetition ... a major disease. One of these latent viruses is the ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic inflammatory ... theory, a study found that RA patients have high concentrations ...
(Date:1/15/2014)... 2013 was a banner year of continued innovation ... continued independent research led by the team at Wake ... million grant from the Susanne Marcus Collins Foundation, had ... reviewed journal, Amy Grant highlighted Brainwave Optimization® in First ...
(Date:1/15/2014)... Toronto, ON (PRWEB) January 15, 2014 ... an experimental new therapy for the treatment of tinnitus. ... unique tinnitus frequency, and over a period of weeks to ... Notched Sound Therapy in two forms: Notched Music and Notched ...
(Date:1/14/2014)... 14, 2014 Date: Friday, April 11, 2014 ... Country Club, 1360 Almshouse Road, Warrington, Pa. , ... solely dedicated to finding a cure for hepatitis B and ... host its annual Crystal Ball on Friday, April 11 at ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
Cached News: