Reexamining irons role in heart disease

Chemically modified forms of the LDL are thought to serve as the direct source of cholesterol in atherosclerotic plaques, but the nature of the chemical modification that converts native LDL to an atherogenic species in vivo is a matter of much debate. LDL can be oxidized in vitro by treatment with iron or other metal ions to generate a form that accumulates in cultured cells, mimicking the genesis of foam cells in the early atherosclerotic lesion. The potential importance of iron in atherogenesis has been suggested frequently, and some epidemiological evidence suggests that high serum iron levels can promote heart disease. Arguing against such an association is the finding that people with the iron-overload disorder hemochromatosis seem to develop arterial lesions more slowly than those in the general population, raising the possibility that high serum iron is somehow protective. Kirk et al. now make a similar observation in a more tractable experimental system. Here, they show that high levels of dietary iron are associated with delayed progression of arterial lesions in atherosclerosis-prone mice. The authors propose no mechanism for this paradoxical effect, although they exclude the possibility that iron overload reduces serum lipoprotein levels or induces a systemic increase in protective antioxidants. It remains possible that iron exerts both pro-and anti-atherogenic roles, but this work raises considerable doubt that the former predominate in the physiological setting.


Contact: John Ashkenas
Journal of Clinical Investigation

Page: 1

Related biology news :

1. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
2. Screen siblings, parents of infants with severe heart abnormalities
3. Recent evolution at a single gene may have brought down heart disease risk in some human groups
4. How do you mend a broken heart?
5. Protemix corporation announces discovery of way to repair hearts damaged by diabetes
6. Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
7. Putting energy into heart protection
8. Rare mutations can significantly increase risk factor for heart disease
9. Smart gene therapy protects against damage from heart attack
10. University of Pittsburgh medical center among first to implant heart assist device
11. Reading hexametric rhyme supports cardiac synchronization, especially after a heart attack

Post Your Comments:

(Date:4/4/2019)... ... 2019 , ... Orbsen Therapeutics, a biotechnology company focused on ... move its base of operations from the National University of Ireland (NUI) Galway ... in Galway, Ireland. , “With four clinical trials in full swing and the ...
(Date:4/4/2019)... ... April 02, 2019 , ... Researchers from Ambry Genetics ... RNA genetic testing (RGT), as a supplement to DNA genetic testing, improves variant ... poster, is one of 13 presentations at the 2019 American College of Medical ...
(Date:4/1/2019)... ... 2019 , ... uBiome announces the issue of patent number ... Patent and Trademark Office on January 1, 2019 with a priority date of ... Zachary Apte, Dr. Daniel Almonacid, Dr. Jessica Richman, and Dr. Catalina Valdivia, and ...
Breaking Biology News(10 mins):
(Date:3/27/2019)... ... March 27, 2019 , ... In honor of National Nutrition Month, Lajollacooks4u ... of healthy meals and good nutrition. This month, Chef Jodi Abel appeared on ... , The first segment addressed the nutritional value of USDA’s MyPlate, a ...
(Date:3/23/2019)... ... March 22, 2019 , ... uBiome has ... a team of researchers at Nnamdi Azikiwe University in Anambra State, Nigeria led ... PhD, of the Department of Medical Laboratory Sciences and Deputy Provost, College of ...
(Date:3/19/2019)... N.J. (PRWEB) , ... March 19, 2019 , ... The ... is a great opportunity to see the most cutting-edge cancer research. The Visikol team ... with 3D cell culture assays as well as their digital pathology ...
(Date:3/19/2019)... ... March 19, 2019 , ... Bogey was nine years old when he injured both ... left hip. These ailments caused Bogey to experience problems with his mobility. According ... and onto his special spot on the couch. , His owners, devastated at the sight ...
Breaking Biology Technology:
Cached News: