HOME >> BIOLOGY >> NEWS
Regeneration in the mammalian heart demonstrated by Wistar researchers

PHILADELPHIA - Mammalian heart tissue may be capable of regenerating itself after serious injury, according to a new study by researchers at The Wistar Institute. Experiments with a strain of laboratory mice known as MRL mice detailed their potent ability to renew damaged heart tissue with minimal scarring. A report on the findings will appear in the online edition of the Proceedings of the National Academy of Sciences on August 7.

Importantly, regeneration of heart tissue in the mice was achieved without the use of drugs, transferred cells or tissues, such as stem cells, or any other intervention. The observed healing is a native capacity of this particular strain of mice.

"In these adult mice, cells in the region of an injury to the heart tissue were replaced over time by new cells that were indistinguishable from neighboring healthy heart cells," says Ellen Heber-Katz, Ph.D., a professor at The Wistar Institute and senior author on the study. "After two months, the damaged heart tissue looked normal and functioned well."

The degree of tissue renewal seen in the MRL mice is strikingly atypical of mammalian heart tissue. Similar injuries to the heart tissue of control mice, for example, showed that only 1 to 3 percent of the heart cells in the region of the injury were capable of dividing. In the MRL mice, however, up to 20 percent of the heart cells divided in response to injury.

The only species known to demonstrate similar capacities for regeneration are non-mammalian species - certain reptiles and amphibians - able to replace limbs and other body parts.

"In more than 15 years of investigations involving muscle tissue, I'd never seen anything like this," says John M. Leferovich, first author on the study. "The observation was quite stunning."

The current study follows on observations of the remarkable regenerative powers of the MRL mice first published by Heber-Katz and her coworkers in 1998. At that time, they not
'"/>

Contact: Franklin Hoke
hoke@wistar.upenn.edu
215-898-3716
The Wistar Institute
6-Aug-2001


Page: 1 2

Related biology news :

1. Land Regeneration Network celebrates first year success
2. Regeneration of injured muscle from adult stem cells
3. Regeneration Technologies introduces advancements at AAOS
4. The Livers Secret Of Regeneration
5. Wistar Institute To Host Regeneration Symposium (Updated Schedule)
6. Wistar Institute To Host Symposium On Regeneration In The 21st Century
7. Wistar Scientists Locate Genes Involved In Mammalian Tissue Regeneration
8. Wistar Scientist Invited To Speak On Regeneration At National Meeting Of American Association For The Advancement Of Science
9. Oak Regeneration In Some Ohio Forests Is Failing, Researchers Find
10. Medicinal Leech May Offer Clues To Neural Regeneration
11. UCLA researchers recreate patterns formed by mammalian cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/15/2016)... Mich. , Dec. 15, 2016  There is ... car doors or starting the engine. Continental will demonstrate ... Las Vegas . Through the combination ... Start and Entry) and biometric elements, the international technology ... of vehicle personalization and authentication. "The integration ...
(Date:12/12/2016)...  Researchers at Trinity College, Dublin, are opening ... the material with Silly Putty. The mixture (known as ... to sense pulse, blood pressure, respiration, and even ... The research team,s findings were published Thursday ... http://science.sciencemag.org/content/354/6317/1257 ...
(Date:12/8/2016)...  Singulex, Inc., the leader in Next Generation Immunodiagnostics ... license and supply agreement with Thermo Fisher Scientific, the ... access to Thermo Scientific BRAHMS PCT (Procalcitonin), a biomarker ... to diagnose systemic bacterial infection and sepsis and in ... in assessing the risk of critically ill patients for ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... January 19, 2017 , ... ... services spanning the full spectrum of drug and device development, and Prism ... pharma/device companies and clinicians, today announced Verified Clinical Trials (VCT) has ...
(Date:1/19/2017)... PLAINVIEW, N.Y. , Jan. 18, 2017 ... pathology services, announces the formation of an Executive Committee ... 2017 and beyond. John Cucci , ... been promoted from Director of Business Development to ... in 2015, Mr. Cucci served in senior sales leadership ...
(Date:1/18/2017)... India , January 18, 2017 According to a ... (Cancer Diagnosis, Neuroscience, Cytology, Infectious Disease), & End User (Molecular Diagnostic Laboratories, Academic ... is expected to reach USD 739.9 Million by 2021 from USD 557.1 Million ... Continue Reading ... MarketsandMarkets Logo ...
(Date:1/18/2017)... , Jan. 18, 2017   Parent Project Muscular ... to end Duchenne muscular dystrophy (Duchenne) , today ... New Jersey Institute of Technology (NJIT) and Talem Technologies ... of robotic technology to assist people living with ... NJIT,s technology – an embedded computer, software, a force ...
Breaking Biology Technology:
Cached News: