HOME >> BIOLOGY >> NEWS
Regeneration in the mammalian heart demonstrated by Wistar researchers

PHILADELPHIA - Mammalian heart tissue may be capable of regenerating itself after serious injury, according to a new study by researchers at The Wistar Institute. Experiments with a strain of laboratory mice known as MRL mice detailed their potent ability to renew damaged heart tissue with minimal scarring. A report on the findings will appear in the online edition of the Proceedings of the National Academy of Sciences on August 7.

Importantly, regeneration of heart tissue in the mice was achieved without the use of drugs, transferred cells or tissues, such as stem cells, or any other intervention. The observed healing is a native capacity of this particular strain of mice.

"In these adult mice, cells in the region of an injury to the heart tissue were replaced over time by new cells that were indistinguishable from neighboring healthy heart cells," says Ellen Heber-Katz, Ph.D., a professor at The Wistar Institute and senior author on the study. "After two months, the damaged heart tissue looked normal and functioned well."

The degree of tissue renewal seen in the MRL mice is strikingly atypical of mammalian heart tissue. Similar injuries to the heart tissue of control mice, for example, showed that only 1 to 3 percent of the heart cells in the region of the injury were capable of dividing. In the MRL mice, however, up to 20 percent of the heart cells divided in response to injury.

The only species known to demonstrate similar capacities for regeneration are non-mammalian species - certain reptiles and amphibians - able to replace limbs and other body parts.

"In more than 15 years of investigations involving muscle tissue, I'd never seen anything like this," says John M. Leferovich, first author on the study. "The observation was quite stunning."

The current study follows on observations of the remarkable regenerative powers of the MRL mice first published by Heber-Katz and her coworkers in 1998. At that time, they not
'"/>

Contact: Franklin Hoke
hoke@wistar.upenn.edu
215-898-3716
The Wistar Institute
6-Aug-2001


Page: 1 2

Related biology news :

1. Land Regeneration Network celebrates first year success
2. Regeneration of injured muscle from adult stem cells
3. Regeneration Technologies introduces advancements at AAOS
4. The Livers Secret Of Regeneration
5. Wistar Institute To Host Regeneration Symposium (Updated Schedule)
6. Wistar Institute To Host Symposium On Regeneration In The 21st Century
7. Wistar Scientists Locate Genes Involved In Mammalian Tissue Regeneration
8. Wistar Scientist Invited To Speak On Regeneration At National Meeting Of American Association For The Advancement Of Science
9. Oak Regeneration In Some Ohio Forests Is Failing, Researchers Find
10. Medicinal Leech May Offer Clues To Neural Regeneration
11. UCLA researchers recreate patterns formed by mammalian cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2017)... public,s help is being enlisted in what,s thought to be the biggest ... human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest study to date ... project's goal is to help advance scientific knowledge of the role of ... The ...
(Date:6/23/2017)... ARMONK, N.Y. and ITHACA, N.Y. ... IBM ) and Cornell University, a leader in dairy ... combined with bioinformatics designed to help reduce the chances ... breaches. With the onset of this dairy project, Cornell ... the Consortium for Sequencing the Food Supply Chain, a ...
(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... in Vilnius, Lithuania, announced today that they have entered into a multiyear collaboration ... to provide CRISPR researchers with additional tools for gene editing across all applications. ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... analysis platform specifically designed for life science researchers to analyze and interpret ... Rosalind Franklin, who made a major contribution to the discovery of the ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is ... and 8th June 2018 in San Francisco, CA. The Summit brings together current and ... distinguished CEOs, board directors and government officials from around the world to address key ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased ... of over 5.5 million people each year. Especially those living in larger cities are ... - based in one of the most pollution-affected countries globally - decided to take ...
Breaking Biology Technology:
Cached News: