Relapses Prevented In Mouse Model Of Multiple Sclerosis: Research Aimed At,,Treating Relapses In Human MS

Researchers at the University of Pennsylvania Medical Center have discovered that antibodies to a common inflammatory-response protein can prevent relapses in an animal model of human multiple sclerosis. "We have been able to prevent relapses in the mouse version of multiple sclerosis using anti-interleukin-12 antibodies for the first time," says Mohamad Rostami, MD, PhD, professor of neurology at Penn's School of Medicine. "Most treatments for MS are first tried out in the experimental allergic encephalomyelitis, or EAE, animal model of MS, before being tested in humans, so this research represents another possible therapy for MS patients." Rostami, Cris Constantinescu, a doctoral student in Rostami's laboratory, and colleagues report their findings in the November 1 issue of the Journal of Immunology.

MS, a neurological disorder, affects 300,000 or more young adults in the United States. Many with the disease suffer from relapses after the initial onset of such symptoms as numbness and paralysis. Trying to remedy these relapses is the research focus of Rostami and his collaborators.

Although the origins of MS remain mysterious, the disorder is considered an autoimmune disease. Immune system cells called T cells cause inflammation in the brain and spinal cord, which is eventually followed by demyelination, the breakdown of the protective sheath that surrounds nerve axons. Certain T cells work in conjunction with proteins called cytokines to cause the damage. "In brains of EAE mice, we saw that the cytokine interleukin-12 is upregulated when there's a relapse and downregulated during a remission," says Rostami. "We believe that both MS and EAE are induced by the Th1 type of T cell. Th2 cells, another type of T cell, are important for recovery from inflammation."

As part of MS-induced inflammation Th2s will try to fight the damage that Th1 cells cause. Rostami reasoned that if the cytokine balance could be changed to decre

Contact: Karen Young Kreeger
University of Pennsylvania School of Medicine

Page: 1 2

Related biology news :

1. U.S. In The Midst Of A Heroin Epidemic, But Many Overdose Deaths Can Be Prevented
2. Cell Suicide Prevented By Survival Signals
3. Half-million dollar landmark achieved for the Methuselah Mouse Prize
4. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
5. Mouse brain stem cells capable of converting into blood vessel cells
6. Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
7. Mouse embryonic germ cells and male gametes created in the lab
8. Mouse, stripped of a key gene, resists diabetes
9. Mouse model of schizophrenia could speed identification of new antipsychotic drugs
10. Mouse study identifies protective mechanism against alcohol-induced embryo toxicity
11. Mouse model offers new explanation for kidney disease and failure

Post Your Comments:

(Date:2/27/2019)... ... 27, 2019 , ... Fluxion Biosciences, a leading developer of precision solutions for ... Institute grant for further development of its ERASE-Seq liquid biopsy technology. The Phase I ... of Dr. Omar Mian at the Cleveland Clinic. , Liquid biopsies offer the potential ...
(Date:2/26/2019)... WORTH, Texas (PRWEB) , ... February 26, 2019 ... ... with Lifecycle since 2018. In her position as Account Manager, Ms. Baptiste demonstrated ... evolve the overall customer experience. Ms. Baptiste was responsible for partnering with both ...
(Date:2/22/2019)... ... February 20, 2019 , ... ... and precision medicine, the traditional line between engineering and medical science grows ever ... and smarter, the medical device industry is making medical practice easier for doctors, ...
Breaking Biology News(10 mins):
(Date:3/4/2019)... (PRWEB) , ... March 04, 2019 , ... Stay on top of current hot topics ... Access to all webinars is free, so be sure to register today to save your ... to see our upcoming webinars: , CLINICAL TRIALS, , March ...
(Date:2/27/2019)... ... February 26, 2019 , ... Superior Controls, Inc., a ... with 140 employees on both the east and west coasts, today announced that ... of New Hampshire. Sandmaier, a senior project engineer, joins Taggart McCormick, P.E., Anthony ...
(Date:2/22/2019)... MURRIETA, Calif. (PRWEB) , ... February 20, 2019 ... ... incubator and SeqOnce , an emerging leader in the rapidly growing NGS ... sample solutions for the Murrieta Genomics laboratory and incubator. , "As an innovation ...
(Date:2/22/2019)... ... February 20, 2019 , ... ... to Novel Captcha Systems. , The patents in lot 92 ... and tests are used to distinguish between human users and computers through exploiting ...
Breaking Biology Technology:
Cached News: