HOME >> BIOLOGY >> NEWS
Relative of snake venom toxin may aid in understanding nicotine addiction

March 18, 2002 -- Scientists have found that a protein resembling snake venom neurotoxin modulates the sensitivity of specific receptors in the brain that are targets of nicotine, the primary addictive drug in tobacco. The researchers say that the protein, lynx1, may be a new tool with which to probe how nicotine and other drugs activate pleasure centers of the brain.

Although studies of lynx1 and other members of this intriguing prototoxin protein family are still in the early stages, the researchers say they may help in understanding nicotine addiction or possibly human genetic diseases caused by defective prototoxins.

Howard Hughes Medical Institute investigatorNathaniel Heintz and his colleagues Ins Ibaez-Tallon and Julie Miwa at The Rockefeller University and colleagues at The Mayo Foundation and Columbia University reported in the March 14, 2002, issue of the journal Neuron that lynx1 is an interesting new modulator of nicotinic acetylcholine receptors.

Julie Miwa, a member of Heintzs laboratory and co-author of the Neuron article, first discovered lynx-1 in 1999. The discovery was especially intriguing, said Heintz, because it confirmed that mammals harbored a natural, or endogenous, protein resembling snake venom that could affect the nervous system. At the time the discovery was made, such an assumption was scientifically risky, said Heintz.

It was an appealing hypothesis that there might be an endogenous neurotoxin-like molecule that regulated some sort of receptor in the nervous system, said Heintz. But Julie was very, very brave to pursue this gene and its protein product on such a flimsy basis.

Miwas initial work showed that lynx1 was concentrated in the nervous system. Additional studies in collaboration with Ibaez-Tallon showed that lynx-1 altered the function of nicotinic acetylcholine receptors. Acetylcholine is a neurotransmitt
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
18-Mar-2002


Page: 1 2 3

Related biology news :

1. Relatives of Parkinsons patients have higher risk for action tremor
2. Relatives Of People with Colorectal Polyps Face Increased Risk For Colorectal Cancer
3. Scientists discover where snakes lived when they evolved into limbless creatures
4. Venom hunt finds harmless snakes a potential danger
5. UGA student questions why snakes cross roadways
6. Sea snake homing instinct could nix translocation
7. Lazy snakes! Pythons can be couch potatoes, too
8. U of C researcher tracks path of flying snake
9. Just one bite at a time: Researchers find snake with unusual feeding habit
10. Unique feeding behavior discovered for snakes
11. Ambushing prey may make snakes vulnerable

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/5/2019)... ... November 05, 2019 , ... Dr. Lauren Kopp ... dentistry to Seattle, WA, including porcelain veneers , smile makeovers, dental implants, ... University of Washington, Dr. Kopp is passionate about serving her Seattle community with ...
(Date:11/2/2019)... ... 2019 , ... Stay on top of current hot topics through free webinars ... webinars is free, so be sure to register today to save your place! Participate ... to see our upcoming webinars: , CLINICAL OPERATIONS , November 14 – Leveraging Technology ...
(Date:10/30/2019)... ... October 30, 2019 , ... The ... Knowledge Center in which participants will learn about precision agriculture tools used to ... these technologies. , Participants will have the opportunity to visit Virginia Tech’s ...
Breaking Biology News(10 mins):
(Date:11/9/2019)... , ... November 08, 2019 ... ... artificial intelligence (AI)-powered technology for use in pathology research, today announced the ... biopsy samples from patients enrolled in the phase 3 selonsertib studies (STELLAR). ...
(Date:11/6/2019)... , ... November 06, 2019 , ... ... through off-the-record collaboration and dialogue, today announces its East/West CEO conference ... in San Francisco. , Kicking off the week of the J.P. ...
(Date:11/5/2019)... ... 2019 , ... Focal Healthcare , an innovator of ... Bx 2.0 prostate fusion biopsy solution. By combining information from multiparametric MRI (mpMRI) ... urologists across Europe the ability to perform targeted transrectal and transperineal prostate biopsies. ...
(Date:11/2/2019)... ... October 31, 2019 , ... A ... communicating with each other: study managers, principal investigators, supply chain managers, manufacturers, IRT, ... is not informed of the latest data, potentially leading to patient risk. , ...
Breaking Biology Technology:
Cached News: