HOME >> BIOLOGY >> NEWS
Relaxed mice may provide clues for treating anxiety

Your heart is racing, you're sweating, trembling, feel exhausted and cannot breathe for over 20 million Americans who face chronic and excessive anxiety each day, these physical reactions to real or imagined danger are well known. Prescription anxiolytics (anxiety-reducing medications), such as clonazepam (Klonopin), alprazolan (Xanax) and lorazepam (Ativan) have been widely employed in the treatment of anxiety disorders to relieve these physical symptoms while other forms of behavioral therapy proceed, however their long-term use is discouraged due to their somewhat addictive potential and sedating side effects. A study reported in the October 1 issue of the Journal of Clinical Investigation (JCI) by Dr. Robert Messing and colleagues from the Ernest Gallo Clinic and Research Center at the University of California, San Francisco, reveals that mice lacking a form of the enzyme protein kinase C (PKCe) are supersensitive to their brain's own calming neurosteroids and exhibit reduced anxiety. The authors suggest that inhibitors of PKCe may be useful in treating anxiety.

Severe and excessive anxiety is associated with irregular levels of neurotransmitters in the brain. These chemicals ferry signals between nerve endings and regulate the activity of nerve cells. An inhibitory agent within the central nervous system, gamma aminobutyric acid (or GABA), is the most important blocker of this communication between neurons and helps control nerve cells from firing too fast. The GABAA receptor forms a closed channel that is triggered to open upon the binding of GABA. A rush of chloride ions through the open channel into the cell inhibits the release of neurotransmitters. In this way, drugs such as barbiturates and the benzodiazepines mentioned above decrease anxiety, induce sleep and even anesthesia.

Earlier studies by this group reveal that mice lacking the gene for PKCe have an increased sensitivity to alcohol, benzodiazepines and barbiturates. These observ
'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Oct-2002


Page: 1 2

Related biology news :

1. Picking prostanoids to provide protection
2. Study by Israeli scientists provides insight on DNA code
3. Adaptive changes in the genome may provide insight into the genetics of complex disease
4. Essential smell gene may provide key to new insect repellents
5. Clemson University spin-off uses corn to make plastics, provide cleaner air
6. Method to visualize gene activity may provide insight into normal development & genome function
7. Study by Tufts biologist provides window into progression of some degenerative diseases
8. New discovery could provide tool to detect whether a cancer will develop and spread
9. Protective mechanism exploited by tumors may provide new cancer treatment
10. Rolling Store provides model for overcoming barriers to healthy foods and better health outcomes
11. Fat cells could provide the key to a longer life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... N.J. , May 16, 2017  Veratad Technologies, ... provider of online age and identity verification solutions, announced ... K(NO)W Identity Conference 2017, May 15 thru May 17, ... Regan Building and International Trade Center. ... the globe and in today,s quickly evolving digital world, ...
(Date:5/6/2017)... , May 5, 2017 ... just announced a new breakthrough in biometric authentication ... exploits quantum mechanical properties to perform biometric authentication. These ... smart semiconductor material created by Ram Group and ... finance, entertainment, transportation, supply chains and security. Ram ...
(Date:4/19/2017)... York , April 19, 2017 ... as its vendor landscape is marked by the presence ... market is however held by five major players - ... Together these companies accounted for nearly 61% of the ... the leading companies in the global military biometrics market ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... ... September 21, 2017 , ... ... who enable the world’s most progressive pharma and biotech organizations to do more ... top pharma and biotech events in Q4. , DrugDev will demonstrate DrugDev Spark™, ...
(Date:9/20/2017)... ... 2017 , ... The award-winning producers behind the American Farmer ... innovations aimed at helping farmers solve the problem of nitrogen loss. The upcoming ... 8:30aET on RFD-TV. Check your local listings for more info. , As ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... of a study examining the effects of exoskeleton-assisted walking on gait parameters ... (SCI). The article, "Neuromechanical adaptations during a robotic powered exoskeleton assisted walking ...
(Date:9/19/2017)... ... 2017 , ... Participants of this educational webinar will learn ... with the advantages and disadvantages of ductless, filtered fume hoods, they will also ... , Attendees will learn from an industry expert about the different types of ...
Breaking Biology Technology:
Cached News: