HOME >> BIOLOGY >> NEWS
Report: Proteins can be engineered as widely adaptable 'bioelectronic' sensors

ing of blood glucose in people with diabetes and could also provide a long-term sensor as the basis for an artificial pancreas.

In other applications, Hellinga foresees use of the biosensors to monitor pollutants and chemical and bio-warfare agents. He emphasized the adaptability of the system. "These engineered proteins are based on proteins that bacteria use to sense their chemical environment, and since there are perhaps hundreds or thousands that exist, they provide a basis for a vast array of chemical sensors," Hellinga said. "Using powerful computational design tools that we have developed, it is possible to engineer these candidates to dramatically alter their specificity and sensitivity."

In contrast, said Hellinga, other approaches to biosensors are more complex and less robust, depending on enzymatic reactions that involve measuring the output of chemical reactions and replenishing consumed chemicals. Also, such biosensors have largely depended on natural proteins, limiting their adaptability. "Our engineered proteins can be thought of as solid-state entities that include both a biological component and an electronic component," he said

In the Science paper, Hellinga and his colleagues described how they started with natural bacterial proteins called "bacterial periplasmic binding proteins." These proteins constitute a large "superfamily" of proteins on the bacterial surface that the organisms use to sense food sources such as sugars and to avoid toxic chemicals.

Besides their broad variability, the major advantage of such proteins is that the protein's chemical-sensing active site is "allosterically" coupled to the domain that sends a signal to the bacterial metabolic pathways. Such internal signals trigger actions such as moving toward a food source. Allosteric coupling means that the two domains are separated on the protein, and thus one can be altered even drastically without affecting the other. In particular, the bacteria
'"/>

Contact: Monte Basgall
monte.basgall@duke.edu
919-681-8057
Duke University
30-Aug-2001


Page: 1 2 3

Related biology news :

1. Science Report: Super-crocodile crawls out of the African Cretaceous
2. Report: auto accidents involving deer still increasing across North Carolina
3. Report: High Carbon Dioxide Boosts Duke Forest Growth By 25 Percent
4. American Heart Association Journal Report: Gene Therapy Findings Updated: Treatment Used In Patients With Blocked Leg Vessels
5. Proteins show promise for mosquito control
6. Proteins transform DNA into molecular velcro
7. Proteins may help identify patients who will respond better to treatments in certain cancers
8. Proteins enable HIV to override cells defenses
9. New Science Press launches Proteins: From Sequence to Structure
10. Proteins in African HIV strains interact differently with drugs
11. Proteins are vastly more complicated than previously realized

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2020)... (PRWEB) , ... February 06, 2020 , ... ... to facilitate access to unique lab-made bioresearch materials, today announced an agreement with ... and plant-based meat and seafood a reality. Under the partnership, terrestrial meat and ...
(Date:1/29/2020)... ... January 29, 2020 , ... Jason Burke has joined CREO, ... providing consulting services for strategy, research and development and data governance to healthcare ... Managing Partner of CREO, an innovative management consulting and advisory firm based in ...
(Date:1/27/2020)... ... January 27, 2020 , ... On Thursday, February 20, 2020 at 10am ... Reed Tech and Richard Castle, Global Account Manager Medical Device at PRISYM ... topics include EU MDR timing deadlines, best practices in creating and submitting product data ...
Breaking Biology News(10 mins):
(Date:2/3/2020)... ... February 03, 2020 , ... ... Cambridge, MA, announce that OmniType, the 11-locus, single tube multiplex successor to Holotype ... a best-in-class product featuring locus-multiplexing and short library preparation, for HLA genotyping from ...
(Date:1/27/2020)... ... January 27, 2020 , ... Valencell, the leading ... strategic investors led by Halma plc , a FTSE 100 global group ... GII LLC, and WSJ Joshua Fund. A representative from Halma will join the ...
(Date:1/22/2020)... (PRWEB) , ... January 20, 2020 , ... ... announced a partnership with WAVE Electronics, the largest independent electronics distributor in the ... to purchase Brilliant Smart Home Systems with leading smart home products from a ...
(Date:1/10/2020)... ... January 09, 2020 , ... ... today announced the acquisition of Cunesoft, a move that expands the company’s portfolio ... of life sciences companies. , Based in Munich, Germany, Cunesoft provides intelligent software ...
Breaking Biology Technology:
Cached News: