Report: Proteins can be engineered as widely adaptable 'bioelectronic' sensors

l protein acts like a hinge, such that when a chemical plugs into the active site, the hinge closes, switching on the distant metabolic signal.

"Since hinge-bending motions are easy to understand, they are easy to manipulate," said Hellinga. In one experiment, for example, the scientists altered a bacterial maltose binding protein, tethering to it a metal ruthenium group that would produce a voltage when its conformation was altered. Thus, when they coated a gold electrode with the proteins and added maltose, that sugar altered the proteins' conformation, producing an electric current proportionate to the maltose concentration.

To demonstrate the generality of their "hinge-bending" mechanism, the scientists created additional bioelectronic sensors using other proteins that responded specifically to glucose and glutamine. And as a demonstration of the extreme adaptability of their system, they radically redesigned the maltose binding protein active site so that it acted as a zinc detector.

Finally, to show that their biosensors could function in complex mixtures without being "confused" by related chemicals or fouled by contaminants, the scientists showed that their bioelectronic sensors could specifically measure maltose concentrations in beer and glucose concentrations in human blood serum.

"We believe that these experiments in real-life mixtures dramatically demonstrated that the chemistry of these systems is very robust and specific, and does not suffer fouling by the multitude of other substances in such mixtures," Hellinga said.


Contact: Monte Basgall
Duke University

Page: 1 2 3

Related biology news :

1. Science Report: Super-crocodile crawls out of the African Cretaceous
2. Report: auto accidents involving deer still increasing across North Carolina
3. Report: High Carbon Dioxide Boosts Duke Forest Growth By 25 Percent
4. American Heart Association Journal Report: Gene Therapy Findings Updated: Treatment Used In Patients With Blocked Leg Vessels
5. Proteins show promise for mosquito control
6. Proteins transform DNA into molecular velcro
7. Proteins may help identify patients who will respond better to treatments in certain cancers
8. Proteins enable HIV to override cells defenses
9. New Science Press launches Proteins: From Sequence to Structure
10. Proteins in African HIV strains interact differently with drugs
11. Proteins are vastly more complicated than previously realized

Post Your Comments:

(Date:2/1/2020)... (PRWEB) , ... February 01, 2020 , ... Liver cancer, ... world and about 700,000 die from the disease. HCC is the 5th most common ... place among all countries when it comes to incidence of HCC, while China has ...
(Date:1/28/2020)... (PRWEB) , ... January 28, 2020 , ... ... life sciences companies and government agencies, announced that the firm has established a ... country. Tunnell’s Cambridge office will be in the Cambridge Innovation Center (CIC), at ...
(Date:1/24/2020)... ... January 24, 2020 , ... The ... Colorado’s capital resources to support early-stage bioscience companies in the state. ... struggled to find the funding they need to innovate and grow. This ...
Breaking Biology News(10 mins):
(Date:2/3/2020)... ... February 03, 2020 , ... Ovation Travel ... Firm Travel, Technology Industry Travel and Biotech/Healthcare Industry Travel Indexes. , All of ... the following statistics:, Average airfare price paid Domestically, ...
(Date:1/28/2020)... ... January 28, 2020 , ... ... exclusive distributor to food and beverage manufactures within North America. Both Lifecycle and ... This agreement will allow each company to pool their collective resources and provide ...
(Date:1/28/2020)... Pa. (PRWEB) , ... January 28, 2020 , ... ... of Better Salivary Assay Kits . The new Salivary Total Human ... research. “By measuring total immunoglobulin G in saliva, researchers can extend the accuracy ...
(Date:1/27/2020)... (PRWEB) , ... January 27, 2020 , ... ... announced it has secured financing from strategic investors led by Halma plc ... from existing investors Sonion, TDF Ventures, GII LLC, and WSJ Joshua Fund. A ...
Breaking Biology Technology:
Cached News: