Report in PNAS on role of nephrin, the kidney filt...( </CENTER An artist's re...)

Report in PNAS on role of nephrin, the kidney filter protein

An artist's rendering of a glomerular capillary surrounded by podocyte pedicels which are interconnected by the slit diaphragm at the capillary-podocyte pedicel interface.

Full size image available through contact

Studies identify nephrin as a key target for therapeutic strategies to improve kidney function

Research Triangle Park, N.C. -- July 6, 1999 -- BioStratum Incorporated announced today the publication in the journal Proceedings of the National Academy of Sciences (volume 96, pages 7962-7967) of the paper entitled "Nephrin is specifically located at the slit diaphragm of the glomerular podocyte". The work was completed in the laboratory of one of BioStratum's founding scientists, Dr. Karl Tryggvason of the Karolinska Institute, Stockholm, Sweden.

In this paper, nephrin is found at the 'slit diaphragm', also referred to as the 'slit membrane', an important structure in the kidney's filtration barrier. Nephrin appears to form a 'zipper-like' filtration structure that functions both as a key structural motif which organizes and maintains the integrity of the filtration barrier as well as a porous filtration structure that allows the liquid portion of the blood to pass but not plasma proteins.

A break-down in the kidney's ability to filter proteins is a common occurrence in most kidney diseases, and results in proteinurea (protein in the urine). Proteinuria is not only a consequence of kidney disease, but also is generally regarded as a major contributing factor to the development of end-stage renal disease, a condition requiring renal placement therapy (transplantation, dialysis). Nephrin's key role in the kidney's filtration barrier suggests that treatments which increase the production of this protein or restore its function are likely to improve kidney function by restoring the kidney's ability to filter proteins. BioStratum owns
'"/>

Contact: Matthew Knight
m.knight@noonanrusso.com
212-696 4455
Noonan/Russo Communications
5-Jul-1999

Page: 1 2 3
Related biology news :

1. Report outlines vision and recommendations for microbiology in the 21st Century
2. Report outlines steps needed to lessen smallpox threat
3. Reporters from Science Magazine to receive ASM Public Communications Award
4. Report in BioScience details global decline of nonmarine mollusks
5. National Academies news: Report on EPAs particulate matter research
6. Report details growing climate change threat to coral reefs
7. Report to aid nation in managing freshwaters
8. Report examines use of antibiotics in agriculture
9. Report offers action plan for curbing diseases that kill millions
10. Report focuses on the science and safety of genetically modified crops
11. Report considers role of science in a world made vulnerable by terrorism

Post Your Comments:

(Date:11/19/2008)..., sponges, jellyfish - have the simplest eyes that...photoreceptor cell and a pigment cell. These minim..., suggested by Charles Darwin as the first eyes to...es but allow the animal to sense the direction of ... swimming towards light exhibited by many zooplank...

(Date:11/19/2008)...earch Hospital have gained new insights into regul...d calpains. , As the cell,s molecular overachie..., including the movement of cells in tissues, the ...in cell and muscle function. The downside of this ... overactive calpains have been linked to an array ...

(Date:11/19/2008)...of star-forming clouds to the flow of the molten E...ur car engine to the coursing blood in your veins,...ion of microscopic animals in the ocean, many of n...uid flow. , The 61st Annual Meeting of the Ameri... which takes place from November 23-25 at the San ...

(Date:11/19/2008)...ient thinker Archimedes shouted "Eureka" in the tu...entist though the ages have solved many of life,s ...he field of fluid dynamics addresses some of the m...eering, alternative energy, and medicine. Later th...ar devoted to the dynamics of fluids convenes in S...

Breaking Biology News(10 mins):Uncovering secrets of life in the ocean 2 New insight into the controls on a go-to enzyme 2 New insight into the controls on a go-to enzyme 3 The physics of star-forming clouds and the urban environment 2 The physics of star-forming clouds and the urban environment 3 The physics of star-forming clouds and the urban environment 4 The physics of star-forming clouds and the urban environment 5 The physics of star-forming clouds and the urban environment 6 Jupiter's shrinking red spot 2 Jupiter's shrinking red spot 3 Jupiter's shrinking red spot 4 Jupiter's shrinking red spot 5 Jupiter's shrinking red spot 6 Jupiter's shrinking red spot 7 Jupiter's shrinking red spot 8 Jupiter's shrinking red spot 9 Jupiter's shrinking red spot 10 Toddlers Affected Most by Secondhand Smoke Exposure at Home 14420 1 Toddlers Affected Most by Secondhand Smoke Exposure at Home 14420 2 Toddlers Affected Most by Secondhand Smoke Exposure at Home 14420 3 Toddlers Affected Most by Secondhand Smoke Exposure at Home 14420 4 Swiss Systems Biology Initiative announces Flagship Projects 14417 1 Swiss Systems Biology Initiative announces Flagship Projects 14417 2 UCR led research team uses tiny wasp to wipe out major agricultural pest in Tahiti 2509 1 UCR led research team uses tiny wasp to wipe out major agricultural pest in Tahiti 2509 2 UCR led research team uses tiny wasp to wipe out major agricultural pest in Tahiti 2509 3 UCR led research team uses tiny wasp to wipe out major agricultural pest in Tahiti 2509 4 Wyeth to Present at the Lehman Brothers Eleventh Annual Global Healthcare Conference 3980 1 Wyeth to Present at the Lehman Brothers Eleventh Annual Global Healthcare Conference 3980 2

[0] Uncovering secrets of life in the ocean [1] New insight into the controls on a go-to enzyme [0] The physics of star-forming clouds and the urban environment [0] Jupiter's shrinking red spot

Other News:

...am, MA A Brandeis University study published in Ce...ly that the circadian cells in fruit flies functio...heir behavior according to seasonal changes. This ...ls, and presumably humans, adjust physiology and b...

...ymbiotic relationshipsin which one organism lives ...and can often significantly shape the biology of t...ight the extent to which a host organism can becom...have identified a case in which the reproduction o...

...ternational team of scientists, including research... in a single gene that plays a key role in determi...eeds and probably is important in determining the ...in the April 6 issue of the journal Science, "is o...

...ternational team led by researchers from the Natio...of the National Institutes of Health (NIH), has id...utor to small size in dogs. The findings appear in.... The identification and characterization of a key...

Networking around the clock 2 Better together: Bacterial endosymbionts are essential for the reproduction of a fungus 2 Researchers identify gene that plays key role in size of dogs 2 Researchers identify gene involved in dog size 2 Researchers identify gene involved in dog size 3 Researchers identify gene involved in dog size 4

Networking around the clock Better together: Bacterial endosymbionts are essential for the reproduction of a fungus Researchers identify gene that plays key role in size of dogs Researchers identify gene involved in dog size

...oston, MA - May 11, 2004 - Caffeine is the world's...do not know exactly how it staves off sleep. Resea...dical School and other institutions have now disco...interacting physiological systems that govern the ...

...HAPEL HILL More than one in 25 young adults in th... causes the sexually transmitted disease known as ...e National Longitudinal Study of Adolescent Health...pel Hill investigation.......If not detected and t...

...AN FRANCISCO, May 11 Injections of botulinum toxi...rnative treatment for the millions of men who have...ommonly referred to as enlarged prostate, accordin...urgh School of Medicine and Chang Gung Memorial Ho...

WHAT:......Digestive Disease Week 2004 (DDW) is hosting special teleconferences to correspond with the news briefings scheduled during its meeting May 15-20 in New Orleans, LA. Following the briefing

health news:New study: Small, frequent doses of caffeine best strategy for staying awake 2 health news:New study: Small, frequent doses of caffeine best strategy for staying awake 3 health news:New study: Small, frequent doses of caffeine best strategy for staying awake 4 health news:New UNC research finds high rate of chlamydia in U.S. young adults 2 health news:New UNC research finds high rate of chlamydia in U.S. young adults 3 health news:Botox helps ease symptoms of enlarged prostate according to Univ. of Pittsburgh study 2 health news:DDW 2004: Turning Science Into Medicine 2

New study: Small, frequent doses of caffeine best strategy for staying awake New UNC research finds high rate of chlamydia in U.S. young adults Botox helps ease symptoms of enlarged prostate according to Univ. of Pittsburgh study DDW 2004: Turning Science Into Medicine

...ent issue of Psychological Science finds that a pe...es. The authors asked biracial participants (one ...lack parent's ethnicity. After, they could spot t...White faces with the same speed and accuracy as a ...

...corticosteroids can reduce breathing problems in p...t they do not prevent the development of persisten...ts from the Childhood Asthma Research and Educatio...Lung, and Blood Institute (NHLBI) of the National ...

...nly involved in cancer onset, has been found to ha...ccording to a study published today in Blood. The ...y investigators from the Lausanne Branch of the in...LICR), showed that c-myc functions in the immune s...

...ts are putting themselves at serious risk of long-...ity, or both, finds a study published on bmj.com t...ing causes of death and illness in the United Stat... never been measured.......Using data from the 200...

health news:Inhaled steroids help young children breathe but do not prevent chronic asthma 2 health news:Inhaled steroids help young children breathe but do not prevent chronic asthma 3 health news:Inhaled steroids help young children breathe but do not prevent chronic asthma 4

Our racial identity affects who we see Inhaled steroids help young children breathe but do not prevent chronic asthma C-myc required by the immune system Over 80 million Americans risking early death through smoking or obesity