Report in PNAS on role of nephrin, the kidney filt...( est proteinuria. said Dr. Tryggvason....)

Report in PNAS on role of nephrin, the kidney filter protein

est proteinuria.", said Dr. Tryggvason. "In support of this strategy are results obtained in our laboratory and other laboratories that demonstrate a correlation between nephrin function and proteinuria in both genetic and acquired kidney diseases."

BioStratum is pursuing several approaches to increase nephrin production including the identification of small molecule drugs that specifically increase nephrin expression, and the application of BioStratum's proprietary Glomerular Gene Transfer Technology. In this approach, a nephrin gene will be transferred into the kidney in order to express a functional nephrin protein to restore the kidney's filtration function. Dr. Tryggvason's group has developed this technology and demonstrated the transfer of functional genes into the kidneys of pigs.

"This advance holds great promise for the development of treatments for a broad range of kidney diseases, which are an enormous medical problem in this country," said Dr. Archie Prestayko, President and CEO of BioStratum. "In fact, the U.S. spends $12 billion annually treating kidney disease, approximately the same amount that it spends treating cancer."

'"/>

Contact: Matthew Knight
m.knight@noonanrusso.com
212-696 4455
Noonan/Russo Communications
5-Jul-1999

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