HOME >> BIOLOGY >> NEWS
Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process

Researchers at UC San Francisco have determined that signals from the reproductive system influence the lifespan of the nematode roundworm C. elegans, a phenomenon that could offer insight into the impact of reproductive development on aging in humans.

In the May 27 issue of Nature, they report that signals from germ cells - the sperm and egg in humans - shorten lifespan, while signals from the somatic gonads - the part of the reproductive tissue that surrounds the germ cells - lengthen lifespan, sending equal but opposite signals.

If the cells that give rise to the germ line are removed, the animals remain youthful longer, and live much longer than normal. And the explanation is not due to the failure of the animals to produce progeny - which researchers have speculated causes wear on the body, and thus aging - because animals that fail to have progeny for other reasons age normally.

Instead, the lifespan of the animal appears to be sensitive to the balance between signals from the germ line and somatic tissue. The authors speculate that this system allows the animal to coordinate its rate of aging with the development of its reproductive system, so that it produces progeny when it is still youthful.

The authors also report in the Nature paper that the reproductive signals act by modulating the activity of two genes - DAF-16 and DAF-2 - in a hormone signaling pathway whose components resemble those of the insulin and IGF-1 hormone systems in humans. The researchers previously discovered that these genes regulate aging in C. elegans.

As the pathway closely resembles the insulin/IGF pathways in humans, researchers suspect that lifespan may be regulated in a similar way in higher organisms, including humans. (Many basic biological processes, such as cell growth and tissue formation, are known to occur similarly in nematodes and humans.) The signals identified in the microscopic nematode have not been characterized, but the researchers
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
26-May-1999


Page: 1 2 3 4 5

Related biology news :

1. University Of Kentucky Professor Teaches First Reproductive Laboratory Science Class In The United States
2. Largest Generation Of Adolescents Faces Reproductive Health Risks
3. Epilepsy: Signals brake in brain impaired
4. Cell Suicide Prevented By Survival Signals
5. Toxic Protein That Interferes With Brain Signals May Trigger Onset Of Alzheimers Disease
6. Maternal Anxiety May Affect Fetal Development
7. Duke Study Finds More Genes May Be Affected By Toxic Cadmium
8. Chopping And Cooking Affect Garlics Anti-Cancer Activity
9. Gene Influences How Lifestyle Affects Blood Cholesterol
10. Wake Forest Physicians Demonstrate How Gene-Diet Interaction Affects Cholesterol Absorption
11. The Best Molecular Snapshot Yet Of Cells Affected By Alzheimers Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... partners with the pharmaceutical and biotechnology industries to improve patient outcomes and quality ... Several trends in analytical testing are being attributed to new regulatory requirements for ...
(Date:10/11/2017)... ... , ... Personal eye wash is a basic first aid supply for any work environment, but ... do you rinse first if a dangerous substance enters both eyes? It’s one less decision, ... its unique dual eye piece. , “Whether its dirt and debris, or an acid or ...
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , ... of Cancer Research, London (ICR) and ... with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple ... as MUK nine . The University of ... is partly funded by Myeloma UK, and ICR will perform ...
(Date:10/10/2017)... ... 10, 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, ... The bold new look is part of a transformation to increase awareness, appeal ... growth period. , It will also expand its service offering from its signature gourmet ...
Breaking Biology Technology:
Cached News: