HOME >> BIOLOGY >> NEWS
Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process

ng were to happen to an individual animal to cause some of its germ cells to develop more slowly than normal, such as a mutation that slows down the development of the germ cells, the number of germ line signals might diminish. As a result, the activity of DAF-16 would go up, which would keep the animals young for a long time," said the lead author of the study, Honor Hsin, a researcher in Kenyon's lab.

Likewise, Hsin said, if something happened during the development of a new species of animal to change the rate of development of the germ line, the rate of aging of the whole species might be slowed down over the course of millions of years so that it wouldn't age too fast for the germ line.

"Our finding demonstrates an inherent relationship between the reproductive state of C. elegans and its lifespan, which may have implications for the co-evolution of reproductive capability and longevity," said Kenyon. "The germ cells can effectively rule the life span of this animal."

While the model proposed by the researchers is compelling in its symmetry, it took the team months to isolate the specific contributions of the biochemical signals, and to determine the genetic controls they modulate. They did so by developing various models of C. elegans.

First, they killed the germ cells of a group of nematodes but left the somatic gonads in tact. These animals remained active and healthy longer than normal and live approximately 60 percent longer. This told them that a germ cell signals somehow decreases lifespan.

They then determined what gene the germ cell signal targets to exact its toll, the suspicion being that it acted on either the DAF-16 or DAF-2 gene, or both. They did so by deleting both the DAF-16 gene and the germ cells from a group of nematodes. Lifespan was not increased. The finding suggested that DAF-16 activity was needed in order for animals missing their germ lines to have long lifespans. In other words, the finding suggested th
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
26-May-1999


Page: 1 2 3 4 5

Related biology news :

1. University Of Kentucky Professor Teaches First Reproductive Laboratory Science Class In The United States
2. Largest Generation Of Adolescents Faces Reproductive Health Risks
3. Epilepsy: Signals brake in brain impaired
4. Cell Suicide Prevented By Survival Signals
5. Toxic Protein That Interferes With Brain Signals May Trigger Onset Of Alzheimers Disease
6. Maternal Anxiety May Affect Fetal Development
7. Duke Study Finds More Genes May Be Affected By Toxic Cadmium
8. Chopping And Cooking Affect Garlics Anti-Cancer Activity
9. Gene Influences How Lifestyle Affects Blood Cholesterol
10. Wake Forest Physicians Demonstrate How Gene-Diet Interaction Affects Cholesterol Absorption
11. The Best Molecular Snapshot Yet Of Cells Affected By Alzheimers Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... -- NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" ... of independent Directors Mr. Robin D. Richards and ... furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer ... guidance and benefiting from their considerable expertise as we move ...
(Date:4/5/2017)... KEY FINDINGS The global market for stem ... 25.76% during the forecast period of 2017-2025. The rise ... growth of the stem cell market. Download ... The global stem cell market is segmented on the ... cell market of the product is segmented into adult ...
(Date:3/30/2017)... 2017 The research team of The Hong ... fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery and ... speed and accuracy for use in identification, crime investigation, immigration control, ... ... A research team led ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... with the addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s ... hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical ...
(Date:10/11/2017)... ... October 11, 2017 , ... Personal eye wash is a basic first aid supply for any ... So which eye do you rinse first if a dangerous substance enters both eyes? It’s ... Wash with its unique dual eye piece. , “Whether its dirt and debris, or ...
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... Disappearing forests ... the lives of over 5.5 million people each year. Especially those living in larger ... startup Treepex - based in one of the most pollution-affected countries globally - decided ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program ... in Volunteer Experience from US2020. , US2020’s mission is to change the trajectory ...
Breaking Biology Technology:
Cached News: